Sepsis is a difficult clinical condition and a leading cause of death in hospitals around the world. Despite advances in medicine, the treatment of sepsis is still a major challenge. The organization '' Surviving Sepsis Campaign '' has developed treatment guidelines that would reduce mortality and improve patient outcomes. One of the recommendations of these guidelines is an early resuscitation method of treatment within the first 6 hours of hospital admission and permanent monitoring of central venous pressure, mean arterial pressure and saturation of central venous blood with oxygen. By monitoring these functions, administration of intravenous fluids, vasoactive drugs and blood products is safer and easier. However, recent researches show that even these methods of treatment are not ideal. In this review, I analyzed such research and concluded that the guidelines recomended by the ''Surviving Sepsis Campaign'' did not bring a significant improvement in the treatment of sepsis. These guidelines did not significantly reduce mortality and improve treatment outcomes compared to conventional access to treatment, while treatment costs increased due to a more aggressive approach to treatment and monitoring of vital functions. Length of stay in the intensive care unit extended. The guidelines recomended by the ''Surviving Sepsis Campaign'' do not have a big advantage over conventional approaches to treating patients with sepsis.