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master's thesis
Personalizirano liječenje kardiovaskularnih bolesti uz pomoć analize farmakogena
Zagreb: University of Zagreb, School of Medicine, 2024. urn:nbn:hr:105:046860
Kujundžić, Josip
University of Zagreb
School of Medicine
Department of Medical Chemistry, Biochemistry and Clinical Chemistry

Institutional repository: Dr Med - University of Zagreb School of Medicine Digital Repository

Cite this document

Kujundžić, J. (2024). Personalizirano liječenje kardiovaskularnih bolesti uz pomoć analize farmakogena (Master's thesis). Zagreb: University of Zagreb, School of Medicine. Retrieved from https://urn.nsk.hr/urn:nbn:hr:105:046860

Kujundžić, Josip. "Personalizirano liječenje kardiovaskularnih bolesti uz pomoć analize farmakogena." Master's thesis, University of Zagreb, School of Medicine, 2024. https://urn.nsk.hr/urn:nbn:hr:105:046860

Kujundžić, Josip. "Personalizirano liječenje kardiovaskularnih bolesti uz pomoć analize farmakogena." Master's thesis, University of Zagreb, School of Medicine, 2024. https://urn.nsk.hr/urn:nbn:hr:105:046860

Kujundžić, J. (2024). 'Personalizirano liječenje kardiovaskularnih bolesti uz pomoć analize farmakogena', Master's thesis, University of Zagreb, School of Medicine, accessed 12 April 2025, https://urn.nsk.hr/urn:nbn:hr:105:046860

Kujundžić J. Personalizirano liječenje kardiovaskularnih bolesti uz pomoć analize farmakogena [Master's thesis]. Zagreb: University of Zagreb, School of Medicine; 2024 [cited 2025 April 12] Available at: https://urn.nsk.hr/urn:nbn:hr:105:046860

J. Kujundžić, "Personalizirano liječenje kardiovaskularnih bolesti uz pomoć analize farmakogena", Master's thesis, University of Zagreb, School of Medicine, Zagreb, 2024. Available at: https://urn.nsk.hr/urn:nbn:hr:105:046860

Metadata
TitlePersonalizirano liječenje kardiovaskularnih bolesti uz pomoć analize farmakogena
Title (english)Personalized treatment of cardiovascular diseases with the help of pharmacogene analysis
AuthorJosip Kujundžić
MentorTamara Božina (mentor)
Committee memberMila Lovrić (predsjednik povjerenstva)
Committee memberSlavica Potočki (član povjerenstva)
Committee memberTamara Božina (član povjerenstva)
GranterUniversity of Zagreb
School of Medicine
(Department of Medical Chemistry, Biochemistry and Clinical Chemistry)
Zagreb
Defense date and country2024-07-12, Croatia
Scientific / art field,
discipline and subdiscipline		BIOMEDICINE AND HEALTHCARE
Basic Medical Sciences
Pharmacology
Scientific / art field,
discipline and subdiscipline		BIOMEDICINE AND HEALTHCARE
Clinical Medical Sciences
Clinical Pharmacology and Toxicology
Scientific / art field,
discipline and subdiscipline		BIOMEDICINE AND HEALTHCARE
Clinical Medical Sciences
Internal Medicine
Abstract
Kardiovaskularne bolesti su globalno vodeći uzrok smrti. One se liječe primjenom brojnih lijekova iz raznih skupina. S obzirom na postojanje razlika među pojedincima u odgovorima na lijekove, u terapiji ovih bolesti je potreban precizan i učinkovit pristup. Farmakogenomika, koja proučava utjecaj genskih varijacija na odgovore bolesnika na lijek, donosi značajan napredak u personalizaciji terapije. U ovom preglednom radu analiziraju se važni farmakogeni koji utječu na farmakodinamiku i... More farmakokinetiku lijekova s djelovanjem na kardiovaskularni sustav. To uključuje pregled polimorfizama membranskih prijenosnika i enzima zaduženih za biotransformaciju lijekova. Primjeri enzima čiji se geni analiziraju su CYP2C9, CYP2C19 i CYP2D6. Njihovi aleli se mogu fenotipski razlikovati s obzirom na razinu enzimske aktivnosti, prema čemu se osobe konačno svrstavaju između sporog i vrlo brzog metabolizatora. Membranski prijenosnici također mogu imati promijenjenu transportnu funkciju zbog varijacija u genima, od kojih su SLCO1B1 i ABCG2 važni kod primjene statina. Zbog ovih razlika pacijenti mogu biti izloženi višim ili manjim količinama lijekova nego što je potrebno i posljedično imati neželjene nuspojave ili smanjen terapijski učinak. Društva kao što su CPIC i DPWG stoga daju kliničarima preporuke o odabiru terapije i doziranju ovisno o genotipu/fenotipu pacijenta. Less
Abstract (english)
Cardiovascular diseases are the leading cause of death globally. They are treated with numerous drugs from various classes. Given the differences among individuals in drug responses, a precise and effective approach is needed in the therapy of these diseases. Pharmacogenomics studies genetic variations that influence drug responses, advancing personalized therapy. This review paper analyzes important pharmacogenes that affect the pharmacodynamics and pharmacokinetics of drugs acting... More on the cardiovascular system. It includes a review of polymorphisms of membrane transporters and enzymes responsible for drug biotransformation. Examples of enzymes whose genes are analyzed include CYP2C9, CYP2C19, and CYP2D6. Their alleles can differ phenotypically regarding the level of enzymatic activity, categorizing individuals as slow to ultra-rapid metabolizers. Membrane transporters can also have altered transport functions due to gene variations, with SLCO1B1 and ABCG2 being important in the use of statins. Due to these differences, patients may be exposed to higher or lower amounts of drugs than necessary, resulting in unwanted side effects or reduced therapeutic efficacy. Groups such as CPIC and DPWG provide clinicians with recommendations on therapy selection and dosing based on the patient's genotype/phenotype. Less
Keywords
Keywords (english)
Languagecroatian
URN:NBNurn:nbn:hr:105:046860
Study programmeTitle: Medicine
Study programme type: university
Study level: integrated undergraduate and graduate
Academic / professional title: doktor/doktorica medicine (doktor/doktorica medicine)
Type of resourceText
File originBorn digital
Access conditionsOpen access
Terms of useLicence In copyright icon
Created on2024-07-02 15:24:36
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