| Abstract | Kronična bubrežna bolest (KBB) predstavlja veliki javnozdravstveni problem u svijetu, a sekundarni hiperparatireoidizam (SHPT) je jedna od najčešćih komplikacija KBB-a. Cilj istraživanja: Utvrditi čimbenike rizika povezane sa SHPT-om u dijaliziranih bolesnika s KBB-om liječenih hemodijalizom u razdoblju 2015. - 2017. godine. Nacrt studije: Presječna studija. Ispitanici i metode: U istraživanje su uključene osobe oba spola, dobi ≥ 18 godina u završnom stupnju KBB-a, liječene hemodijalizom u Općoj županijskoj bolnici Pakrac i bolnici hrvatskih veterana. Podaci o ispitanicima i laboratorijskim vrijednostima prikupljani su iz povijesti bolesti uz odobrenje Etičkog povjerenstva Bolnice. Kao programska potpora u provedbi istraživanja korišten je programski paket paketom SPSS (inačica 21.0, SPSS Inc., Chicago, Illinois, SAD). Rezultati: Prikupljene su i analizirane laboratorijske pretrage PTH, CRP, urea, kreatinin, hemoglobin, albumini, kolesterol, trigliceridi, kalcij, fosfor i bikarbonati za 49 ispitanika, od čega 19 žena i 30 muškaraca, najviše u dobnoj skupini 71-91 godine (51 %). Nađena je negativna korelacija između vrijednosti PTH i kolesterola, te pozitivna korelacija između vrijednosti PTH i kalcija. CRP iznad normalnih vrijednosti ima 92 % ispitanika, albumin je snižen kod 85 % ispitanika, dok je 96 % ispitanika u anemiji. Zaključak: Analizom višestrukih čimbenika rizika za razvoj SHPT-a u dijaliziranih bolesnika nađena je statistički značajna poveznica između vrijednosti PTH s kolesterolom i kalcijem. Iako je većina ispitanika pod dobrom kontrolom PTH, većina ih je u hipokalcijemiji i hiperfosfatemiji, te ih karakteriziraju stanje kronične upale i pothranjenosti te anemija. |
| Abstract (english) | Chronic kidney disease (CKD) is a major public health concern in the world, and secondary hyperparathyroidism (SHPT) is one of the most common complications of CKD. Aim: The aim was to establish the risk factors related to SHPT in dialysed patients with CKD, treated with haemodialysis in the period from 2015 to 2017. Study design: Cross-sectional study. Subjects and methods: The research included both sexes, aged ≥ 18 years, in the end stage of renal disease, treated with haemodialysis in the General Municipal Hospital Pakrac and the Hospital of Croatian Veterans. Data on subjects and laboratory values was collected from the medical history, following the approval of the Ethics Committee of the Hospital. Software SPSS was used as programme support for carrying out the study (version 21.0, SPSS Inc., Chicago, Illinois, USA). Results: The following laboratory parameters were collected and analysed: PTH, CRP, urea, creatinine, haemoglobin, albumins, cholesterol, triglycerides, calcium, phosphorus and bicarbonates for 49 subjects, of which 19 females and 30 males, mostly of the age group 71-91 years (51 %). Negative correlation was found between the values of PTH and cholesterol, while positive correlation was found between the values of PTH and calcium. 92 % of subjects had higher CRP than normal reference range, albumin was lowered in 85 % of subjects, whereas 96 % of subjects had anaemia. Conclusion: The analysis of multiple risk factors for the development of SHPT in dialysed patients showed a statistically significant correlation between the values of PTH and cholesterol and calcium. Even though most of the subjects were under good PTH control, most of them had hypocalcaemia or hyperphosphatemia, and were characterised by chronic inflammation, malnutrition and anaemia. |
