Introduction: Hemorragic Fever with Renal Syndrome (HFRS) is acute virus zoonosis caused by hantaviruses, endemic in Croatia. Aim: The aim was to show clinical and laboratory characteristics of the disease in patients in the period from January 2012 to December 2017. The patients were treated at the Department of Infectious Diseases of the General Hospital „Dr. Ivo Pedišić“ in Sisak. Study Design: Cross – sectional study. Subjects and methods: The research included patients of both sexes, over 18 years old, with laboratory-confirmed diagnosis of HFRS. The data on patients was collected from medical records. Results: Puumala virus was serologically confirmed in 89,5 % of subjects, and Dobrava virus in 7 % of subjects. 87,7 % of subjects were male, and 12,3 % female. A sex-related statistically significant difference was established in terms of the development of the disease. The age group of 40 – 49 years is most likely to develop the disease (29,8 %). The disease most often appers during summer months. The fever was present in 92,8 % of subjects, with women having more symptoms on average than man. Thrombocytopenia was present in 82,9 % of subjects, most patients had lowered values of haemoglobin and lymphocyte and elevated values of non-segmented granulocytes. All subjects had elevated values of CRP and D-dimer, 60 % of patients had elevated values of fibrinogen. Urea values were elevated in 93,3 % of patients, and creatinine values in 91,7 %. The values of sodium and potassium are lowered. Proteinuria and hematuria were noted. Conclusion: It was confirmed by the study that the classic picture of HFRS is comprised of three symptoms: fever, hemorragic diathesis and kidney failure. Thrombocytopenia, as well as elevated levels of urea and creatinine are an important indicator of the disease.