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master's thesis
Gustoća intraepidermalnih vlakana u Sprague Dawley štakora intrauterino tretiranih antihistaminicima desloratadinom i bilastinom
Osijek: Josip Juraj Strossmayer University of Osijek, Faculty of Medicine Osijek, 2020. urn:nbn:hr:152:443520
Lulić, Doris
Josip Juraj Strossmayer University of Osijek
Faculty of Medicine Osijek

Institutional repository: Repository of the Faculty of Medicine Osijek

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Lulić, D. (2020). Gustoća intraepidermalnih vlakana u Sprague Dawley štakora intrauterino tretiranih antihistaminicima desloratadinom i bilastinom (Master's thesis). Osijek: Josip Juraj Strossmayer University of Osijek, Faculty of Medicine Osijek. Retrieved from https://urn.nsk.hr/urn:nbn:hr:152:443520

Lulić, Doris. "Gustoća intraepidermalnih vlakana u Sprague Dawley štakora intrauterino tretiranih antihistaminicima desloratadinom i bilastinom." Master's thesis, Josip Juraj Strossmayer University of Osijek, Faculty of Medicine Osijek, 2020. https://urn.nsk.hr/urn:nbn:hr:152:443520

Lulić, Doris. "Gustoća intraepidermalnih vlakana u Sprague Dawley štakora intrauterino tretiranih antihistaminicima desloratadinom i bilastinom." Master's thesis, Josip Juraj Strossmayer University of Osijek, Faculty of Medicine Osijek, 2020. https://urn.nsk.hr/urn:nbn:hr:152:443520

Lulić, D. (2020). 'Gustoća intraepidermalnih vlakana u Sprague Dawley štakora intrauterino tretiranih antihistaminicima desloratadinom i bilastinom', Master's thesis, Josip Juraj Strossmayer University of Osijek, Faculty of Medicine Osijek, accessed 25 November 2024, https://urn.nsk.hr/urn:nbn:hr:152:443520

Lulić D. Gustoća intraepidermalnih vlakana u Sprague Dawley štakora intrauterino tretiranih antihistaminicima desloratadinom i bilastinom [Master's thesis]. Osijek: Josip Juraj Strossmayer University of Osijek, Faculty of Medicine Osijek; 2020 [cited 2024 November 25] Available at: https://urn.nsk.hr/urn:nbn:hr:152:443520

D. Lulić, "Gustoća intraepidermalnih vlakana u Sprague Dawley štakora intrauterino tretiranih antihistaminicima desloratadinom i bilastinom", Master's thesis, Josip Juraj Strossmayer University of Osijek, Faculty of Medicine Osijek, Osijek, 2020. Available at: https://urn.nsk.hr/urn:nbn:hr:152:443520

Metadata
TitleGustoća intraepidermalnih vlakana u Sprague Dawley štakora intrauterino tretiranih antihistaminicima desloratadinom i bilastinom
Title (english)Intaepidermal fiber density in Sprague Dawley rats following intrauterine treatment with antihistamines dosloratadine and bilastine
AuthorDoris Lulić
MentorMarija Heffer (mentor)
Committee memberNikola Bijelić (predsjednik povjerenstva)
Committee memberDarija Šnajder Mujkić (član povjerenstva)
Committee memberMarija Heffer (član povjerenstva)
GranterJosip Juraj Strossmayer University of Osijek
Faculty of Medicine Osijek
Osijek
Defense date and country2020-09-28, Croatia
Scientific / art field,
discipline and subdiscipline		BIOMEDICINE AND HEALTHCARE
Basic Medical Sciences
Abstract
Ciljevi: Koristeći hematoksilin-eozin histološko bojenje tkiva prikazati morfološke karakteristike tkiva uške štakora starosti 3 mjeseca eksperimentalnih skupina životinja (potomci majki tretiranih antihistaminicim) u odnosu na kontrolnu skupinu (potomci netretiranih majki). Imunokemijskim bojenjem tkiva na specifičan marker C i Aδ vlakana, protein produkt gena 9.5 (PGP9.5), usporediti gustoću intraepidermalnih živčanih vlakana po mm2 poprečnog presjeka uške u životinja eksperimentalnih skupina s kontrolama. Nacrt studije: Istraživanje je zamišljeno kao studija parova. U studiju su uključene tri skupine Sprague Dawley štakora, čije su majke od 10. gestacijskog dana trudnoće tretirane antihistaminicima desloratidinom ili bilastinom, odnosno nisu tretirane. Skupine su dalje podijeljene na muške i ženske potomke (ukupno 6 skupina). Materijali i metode: Imunohistokemijskom analizom pomoću protutijela PGP 9.5 i hematoksilin-eozin bojenja određena je gustoća intraepidermalnih vlakana i morfološke karakteristike tkiva uške. Rezultati: Postoji statistički značajna razlika između muške skupine potomaka Sprague Dawley štakorica koje su tijekom intrauterinog razvoja potomaka tretirane bilastinom i muške skupine tretirane desloratadinom. Rezultat dvostranog ANOVA testa prikazuje statistički značajan utjecaj spola i antihistaminika na gustoću vlakana. Zaključak: Ženke imaju veću gustoću H1 pozitivnih intraepidermalnih vlakana od mužjaka. Ne može se isključiti mogućnost intrauterinog djelovanja bilastina i desloratadina.
Abstract (english)
Objectives: Using haematoxylin-eosin histological staining of tissue to show morphological characteristics of ear tissue of rats aged 3 months in experimental groups of animals (offsprings of mothers treated with antihistamines) in relation to the control group (offsprings of untreated mothers). With immunochemical staining of tissues for a specific marker of C and Aδ fibers, protein gene product 9.5 (PGP9.5), compare the density of intraepidermal fibers per mm2 of cross-section of the ear in experimental groups of animals with controls. Study Design: The study was designed as a case-control study. The study included three groups of animals whose mothers, Sprague Dawley rats, had been treated with the antihistamines desloratidine or bilastine since the 10th gestational day of pregnancy, or had not been treated. The groups were further divided into male and female offsprings (6 groups in total). Materials and methods: With immunohistochemical analysis using PGP 9.5 antibody and haematoxylin-eosin staining, density of intraepidermal fibers and the morphological characteristics of the ear tissue were determined. Results: There is a statistically significant difference between the male group of offsprings of Sprague Dawley rats treated with bilastine during intrauterine development of the offspring and the male group treated with desloratadine. The result of a two-way ANOVA test shows a statistically significant effect of gender and antihistamines on fiber density. Conclusion: Female rats have a higher density of H1 positive intraepidermal fibers than males. The possibility of intrauterine action of bilastine and desloratadine cannot be ruled out.
Keywords
Keywords (english)
Languagecroatian
URN:NBNurn:nbn:hr:152:443520
Study programmeTitle: University graduate study
Study programme type: university
Study level: graduate
Academic / professional title: magistar/magistra medicinsko laboratorijske dijagnostike (magistar/magistra medicinsko laboratorijske dijagnostike)
Type of resourceText
File originBorn digital
Access conditionsOpen access
Terms of useLicence In copyright icon
Created on2020-12-18 09:35:25