Nurses’ opinions on adverse events in the process of nursing care in the Clinical Hospital Center Osijek Introduction. The most common adverse events associated with the process of nursing care are bedsores, falls, hospital-acquired infections, insufficient hand hygiene and unwanted adverse effects related to drugs. The aim. The aim of this study was to investigate the views of respondents on adverse events during the process of nursing care in the Clinical Hospital Center Osijek. Respondents and methods. A qualitative cross-sectional study was conducted in an anonymous survey on a sample of 100 nurses in February and March 2016, at the clinics of surgery, internal medicine and anesthesiology, intensive care unit, emergency room and neurology. Results. The study has shown that nurses actively improve patient safety (82 % of respondents). The nurses, 71.7 % of them, feel that the mistakes reflect on them, while 67.7 % of the respondents agree with the claim that the mistakes led to positive changes. When an adverse event is reported, 74.2 % of nurses feel as if they are the ones being reported, and not the problem itself. After they make changes to improve patient safety, 83.5 % of the nurses judge their effectiveness. The respondents, 33.4 % of them, claim that they have patient safety issues at their ward, and 49 (50 %) of the respondents claim that the procedure and the system are efficient at preventing mistakes. Most respondents (57.1 %) rated patient safety as acceptable. In similar studies that were conducted in US hospitals, there was generally a higher level of patient safety culture by several grade points. Conclusion. Nurses agree that patient safety culture regarding adverse events in the process of nursing care in the Clinical Hospital Centre Osijek is acceptable, and that they are responsible for protecting and improving patient safety.