OBJECTIVE: The objective of this study was to examine the existence of arterial hypertension in patients with migraine and to research the effect of antihypertensive therapy on the occurrence and intensity of migraine attacks and on the quality of life of patients. STUDY DESIGN: This is a cross sectional study. PARTICIPANTS AND METHODS: The study included 30 patients suffering from migraines treated at the Headache Clinic of the Department of Neurology of the University Hospital Centre Osijek. The following research instruments were used: an anonymous questionnaire structured for this research to gather the demographic data of the patients and the data on the clinical features of migraine and blood pressure, and the standardized Short Form Health Survey, SF-36. RESULTS: High blood pressure is present in 12 patients with migraine (40%). Ten (33%) patients are treated for arterial hypertension as well. There is no significant difference in the intensity and duration of migraine and the presence of high blood pressure and taking antihypertensive therapy. In the SF-36 test, physical functioning (P=0.03) and social functioning (P=0.01) were significantly better in patients without hypertension, compared to those with hypertension. Physical functioning (P=0.003) and limitation due to physical difficulties (P=0.02) as well as the overall domain of physical health (0.004) were significantly better in patients not taking high blood pressure therapy. CONCLUSION: In patients with migraine, arterial hypertension is the most common comorbidity. Elevated blood pressure values do not affect clinical features (intensity and duration of seizures). Quality of life related to physical and social functioning is reduced in patients with migraine if they also suffer from arterial hypertension, and antihypertensives may affect the occurrence of physical difficulties in these patients, which is probably correlated with complications in the treatment of hypertension.