Objectives: To determine levels of homocysteine and high-sensitive C-reactive protein (hsCRP) in patients suffering from psoriasis vulgaris and in healthy controls, as well as assess the severity of clinical manifestations of psoriasis vulgaris and its relationship with serum homocysteine levels, hsCRP, anthropometric, hematological and biochemical measurements. Study design: Case-control study Participants and Methods: This study included 24 adult, unrelated, by sex and age matched participants, from whom 14 were psoriasis patients and 10 healthy controls. The participants had homocysteine and high-sensitive C-reactive protein concentration and other hematological and biochemical parameters determined in a venous blood sample, and the severity of disease was assessed by PASI (Psoriasis Area Severity Index) and DLQI (Dermatology Life Quality Index) questionnaires. Results: Patients with psoriasis vulgaris had significantly higher homocysteine levels compared to healthy controls. A positive association of homocysteine with age and DLQI was observed, and a negative association with vitamin B12. Fibrinogen activity, hsCRP levels were also higher in PV group and positively correlated to other inflammatory parameters and disease severity (PASI). Conclusion: Homocysteine and hsCRP levels, as well as fibinogen activity were significantly elevated in patients with PV compared to healthy controls and positively correlated with inflammatory parameters (erythrocyte sedimentation rate, white blood cell count). The PASI index positively correlates with levels of inflammatory parameters and hsCRP. Homocysteine, hsCRP, PASI index and accompanying inflammatory parameters have the potential as biomarkers for monitoring disease severity and risk for developing cardiovascular disease.