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master's thesis
Antitrombotska terapija i ponovljeni moždani udar u osoba s fibrilacijom atrija.
Osijek: Josip Juraj Strossmayer University of Osijek, Faculty of Medicine Osijek, 2021. urn:nbn:hr:152:813594
Vidaković, Dorotea
Josip Juraj Strossmayer University of Osijek
Faculty of Medicine Osijek

Institutional repository: Repository of the Faculty of Medicine Osijek

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Vidaković, D. (2021). Antitrombotska terapija i ponovljeni moždani udar u osoba s fibrilacijom atrija. (Master's thesis). Osijek: Josip Juraj Strossmayer University of Osijek, Faculty of Medicine Osijek. Retrieved from https://urn.nsk.hr/urn:nbn:hr:152:813594

Vidaković, Dorotea. "Antitrombotska terapija i ponovljeni moždani udar u osoba s fibrilacijom atrija.." Master's thesis, Josip Juraj Strossmayer University of Osijek, Faculty of Medicine Osijek, 2021. https://urn.nsk.hr/urn:nbn:hr:152:813594

Vidaković, Dorotea. "Antitrombotska terapija i ponovljeni moždani udar u osoba s fibrilacijom atrija.." Master's thesis, Josip Juraj Strossmayer University of Osijek, Faculty of Medicine Osijek, 2021. https://urn.nsk.hr/urn:nbn:hr:152:813594

Vidaković, D. (2021). 'Antitrombotska terapija i ponovljeni moždani udar u osoba s fibrilacijom atrija.', Master's thesis, Josip Juraj Strossmayer University of Osijek, Faculty of Medicine Osijek, accessed 27 December 2024, https://urn.nsk.hr/urn:nbn:hr:152:813594

Vidaković D. Antitrombotska terapija i ponovljeni moždani udar u osoba s fibrilacijom atrija. [Master's thesis]. Osijek: Josip Juraj Strossmayer University of Osijek, Faculty of Medicine Osijek; 2021 [cited 2024 December 27] Available at: https://urn.nsk.hr/urn:nbn:hr:152:813594

D. Vidaković, "Antitrombotska terapija i ponovljeni moždani udar u osoba s fibrilacijom atrija.", Master's thesis, Josip Juraj Strossmayer University of Osijek, Faculty of Medicine Osijek, Osijek, 2021. Available at: https://urn.nsk.hr/urn:nbn:hr:152:813594

Metadata
TitleAntitrombotska terapija i ponovljeni moždani udar u osoba s fibrilacijom atrija.
Title (english)Impact of prior antithrombotic therapy on outcome of recurrent ischemic stroke in patients with atrial fibrillation.
AuthorDorotea Vidaković
MentorHrvoje Budinčević (mentor)
Committee memberSilva Butković Soldo (predsjednik povjerenstva)
Committee memberDavor Jančuljak (član povjerenstva)
Committee memberHrvoje Budinčević (član povjerenstva)
GranterJosip Juraj Strossmayer University of Osijek
Faculty of Medicine Osijek
Osijek
Defense date and country2021-07-19, Croatia
Scientific / art field,
discipline and subdiscipline		BIOMEDICINE AND HEALTHCARE
Clinical Medical Sciences
Neurology
Abstract
Ciljevi istraživanja: Ispitati utjecaj prethodne antitrombotske terapije te utjecaj prethodne antikoagulantne, antiagregacijske i bez terapije na ishod osoba s ponovljenim ishemijskim moždanim udarom i fibrilacijom atrija u pogledu veličine, lokalizacije, težine moždanog udara te stupnja onesposobljenosti. Nacrt studije: Presječna studija. Ispitanici i metode: Prikupljeni su podaci o vrsti antitrombotske monoterapije, dobi, spolu, čimbenicima rizika, INR-u, i ishodu moždanog udara osoba s fibrilacijom atrija i ponovljenim ishemijskim moždanim udarom na Klinici za neurologiju Kliničke bolnice „Sveti Duh“ (2004. - 2016. godine). Rezultati: Ispitanici ove studije stariji su (medijan 79 godina) i češće žene (65 %). Od osoba s prethodno poznatom dijagnozom fibrilacije atrija antikoagulantnu terapiju uzimalo je 137 (37,53 %) ispitanika, antiagregacijsku 129 (35,34 %) te je bez terapije bilo 99 (27,12 %) ispitanika. Ispitanici na antikoagulantnoj terapiji mlađi su (P = 0,04) u odnosu na ispitanike bez antitrombotske terapije, te češće imaju kardiomiopatiju (P = 0,02) u odnosu na ispitanike na antiagregacijskoj terapiji i bez terapije. Lakunarni moždani udari bili su rjeđi su u ispitanika na antiagregacijskoj terapiji (P = 0,048), ali češći u ispitanika na dobro reguliranoj antikoagulantnoj terapiji (P = 0,045). Zaključak: Osobe s ponovljenim moždanim udarom i poznatom fibrilacijom atrija primale su antikoagulantnu terapiju u svega 37,53 % slučajeva. Nije uočen značajan utjecaj antitrombotske terapije na ishod moždanog udara (veličina, lokalizacija, težina, i stupanj onesposobljenosti). Lakunarni moždani udari bili su rjeđi su u ispitanika na antiagregacijskoj terapiji, ali češći u ispitanika na dobro reguliranoj antikoagulantnoj terapiji. Sekundarna prevencija antikoagulansima češće se propisivala mlađim osobama s kardiomiopatijom.
Abstract (english)
Objectives: To investigate the impact of previous antithrombotic (anticoagulant and antiplatelet) therapy and no therapy on patients with recurrent ischemic stroke and atrial fibrillation in terms of size, location, severity of stroke, and disability. Study design: Cross-sectional study. Subjects and methods: Data were collected on the type of antithrombotic monotherapy, age, sex, risk factors, INR, and stroke outcome of persons with atrial fibrillation and recurrent ischemic stroke at the Neurology Clinic of the Sveti Duh University Hospital (2004. – 2016.). Results: The subjects of this study were older (median 79 years) and more often women (65 %). In the group with previous diagnosis of atrial fibrillation, 137 (37,53 %) subjects took anticoagulant therapy, 129 (35,34 %) antiaggregation therapy, and 99 (27,12 %) were without therapy. Subjects on anticoagulant therapy were younger (P = 0.04), in comparison to subjects without antithrombotic therapy, and more often had cardiomyopathy (P = 0,02) compared to antiplatelet therapy and without therapy. Lacunar stroke is less common in subjects on prior antiplatelet therapy (P = 0,048), but more common in patients on well regulated anticoagulant therapy (p=0,045). Conclusion: People with recurrent stroke and known atrial fibrillation received antikoagulant therapy in only 37,53 % of cases. No significant impact of antithrombotic therapy on stroke outcome (size, location, severity, and disability) was demonstrated. Lacunar stroke is less common in subjects on prior antiplatelet therapy, but more common in patients on well regulated anticoagulant therapy. Secondary prevention with anticoagulants was more often prescribed to younger people with cardiomyopathy.
Keywords
Keywords (english)
Languagecroatian
URN:NBNurn:nbn:hr:152:813594
Study programmeTitle: University Graduate Studies
Study programme type: university
Study level: integrated undergraduate and graduate
Academic / professional title: doktor/doktorica medicine (doktor/doktorica medicine)
Type of resourceText
File originBorn digital
Access conditionsOpen access
Terms of useLicence In copyright icon
Created on2023-03-22 08:51:28