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master's thesis
Povezanost izražaja interleukina (IL)-17A u koži s težinom kliničke slike lichen planusa
Osijek: Josip Juraj Strossmayer University of Osijek, Faculty of Medicine Osijek, 2022. urn:nbn:hr:152:804520
Pauzar, Mirta
Josip Juraj Strossmayer University of Osijek
Faculty of Medicine Osijek

Institutional repository: Repository of the Faculty of Medicine Osijek

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Pauzar, M. (2022). Povezanost izražaja interleukina (IL)-17A u koži s težinom kliničke slike lichen planusa (Master's thesis). Osijek: Josip Juraj Strossmayer University of Osijek, Faculty of Medicine Osijek. Retrieved from https://urn.nsk.hr/urn:nbn:hr:152:804520

Pauzar, Mirta. "Povezanost izražaja interleukina (IL)-17A u koži s težinom kliničke slike lichen planusa." Master's thesis, Josip Juraj Strossmayer University of Osijek, Faculty of Medicine Osijek, 2022. https://urn.nsk.hr/urn:nbn:hr:152:804520

Pauzar, Mirta. "Povezanost izražaja interleukina (IL)-17A u koži s težinom kliničke slike lichen planusa." Master's thesis, Josip Juraj Strossmayer University of Osijek, Faculty of Medicine Osijek, 2022. https://urn.nsk.hr/urn:nbn:hr:152:804520

Pauzar, M. (2022). 'Povezanost izražaja interleukina (IL)-17A u koži s težinom kliničke slike lichen planusa', Master's thesis, Josip Juraj Strossmayer University of Osijek, Faculty of Medicine Osijek, accessed 08 November 2024, https://urn.nsk.hr/urn:nbn:hr:152:804520

Pauzar M. Povezanost izražaja interleukina (IL)-17A u koži s težinom kliničke slike lichen planusa [Master's thesis]. Osijek: Josip Juraj Strossmayer University of Osijek, Faculty of Medicine Osijek; 2022 [cited 2024 November 08] Available at: https://urn.nsk.hr/urn:nbn:hr:152:804520

M. Pauzar, "Povezanost izražaja interleukina (IL)-17A u koži s težinom kliničke slike lichen planusa", Master's thesis, Josip Juraj Strossmayer University of Osijek, Faculty of Medicine Osijek, Osijek, 2022. Available at: https://urn.nsk.hr/urn:nbn:hr:152:804520

Metadata
TitlePovezanost izražaja interleukina (IL)-17A u koži s težinom kliničke slike lichen planusa
Title (english)Correlation between expression of Interleukin (IL)-17A in the skin and the severity of clinical presentation of lichen planus
AuthorMirta Pauzar
MentorMartina Mihalj (mentor)
Committee memberBranko Dmitrović (predsjednik povjerenstva)
Committee memberBranka Lončar (član povjerenstva)
Committee memberMartina Mihalj (član povjerenstva)
GranterJosip Juraj Strossmayer University of Osijek
Faculty of Medicine Osijek
Osijek
Defense date and country2022-07-15, Croatia
Scientific / art field,
discipline and subdiscipline		BIOMEDICINE AND HEALTHCARE
Clinical Medical Sciences
Dermatovenerology
Abstract
Cilj istraživanja: Cilj ove studije bio je ispitati postoje li razlike u imunohistokemijskom izražaju IL - 17 u uzorcima zdrave kože i lezijama lichen planusa. Isto tako, cilj je bio usporediti podatke imunoekspresije IL - 17 u uzorcima oboljelih sa različitim kliničkim obilježjima i lokalizacijama kožnih lezija. Nacrt studije: Presječna studija Ispitanici i metode: U ovo istraživanje uključeno je 30 uzoraka, od kojih je 10 zdrava koža, a 20 uzoraka lichen planusa. Uzorci su prikupljeni na Zavodu za patologiju Kliničkog bolničkog centra Osijek. Rezultati: Dobiveni rezultati pokazali su da postoji značajna razlika u imunoekspresiji IL - 17 koja je veća kod uzoraka lichen planusa (P < 0,001), ali da ne postoji značajna razlika u imunoekspresiji IL - 17 između generaliziranog i lokaliziranog oblika lichen planusa (P = 0,56). Također je uočeno kako je značajno viša imunoekspresija IL - 17 kod uzoraka bolesnika koji su imali kliničke promjene i na koži i na sluznicama usporedno s bolesnicima kojima je sluznica bila klinički nepromijenjena (P = 0,003). Zaključak: Ovom presječnom studijom potvrđeno je da je izražaj proteina IL - 17 veći kod uzoraka lichen planusa u odnosu na zdravu kožu, te u onih uzoraka gdje su bolesnici osim kože imali zahvaćenu i sluznicu. S obzirom na lokalizaciju lezija lichen planusa, ne postoji značajna razlika izražaja IL - 17.
Abstract (english)
Objectives: The goal of this study was to examine whether there are differences in the immunohistochemical expression of IL - 17 in healthy skin samples and lichen planus lesions. Thea aim was also to compare immunoexpression data in lichen planus skin samples of different clinical properties and skin lesions localization. Study design: The study was conducted as a cross - sectional study. Subjects and methods: 30 samples were included in this study: 10 of healthy skin, and 20 of lichen planus patients. Samples were collected at the Departmend of Pathology of the Clinical Hospital Center Osijek. Results: The obtained results showed that there is a significant difference in IL - 17 immunoexpression that is higher in lichen planus samples (P < 0,001), and that there is no significant difference in IL - 17 immunoexpression between generalized and localized lichen planus form (P = 0,56). It is also determined that the immunoexpression of IL - 17 is significantly higher in patients who have experienced both skin and mucose lesions, rather then only skin lesions(P = 0,003). Conclusion: This cross - sectional study confirmed that the expression of protein IL - 17 is higher in lichen planus samples than in those of healthy skin, and in samples of patients who have suffered both skin and mucose lesions. There is no significant difference in IL - 17 expression reagarding lichen planus localization.
Keywords
Keywords (english)
Languagecroatian
URN:NBNurn:nbn:hr:152:804520
Study programmeTitle: University Graduate Studies
Study programme type: university
Study level: integrated undergraduate and graduate
Academic / professional title: doktor/doktorica medicine (doktor/doktorica medicine)
Type of resourceText
File originBorn digital
Access conditionsOpen access
Terms of useLicence In copyright icon
Created on2023-06-01 10:34:02