Objectives: • Examine for differences in lipidogram values one year after the incident. • Examine the presence of familial hypercholesterolemia by calculating the Dutch Lipid Score with long-term monitoring of LDL cholesterol levels in individuals with acute myocardial infarction with concomitantly high LDL-K levels. • Examine the frequency of other biochemical characteristics of patients (renal failure, anemia) and the presence of other cardiovascular risk factors. Study Design: Cohort study from historical dana. Patients and Methods: The study included patients hospitalized for acute myocardial infarction with LDL cholesterol values of 4.5 mmol / L or higher at the Department of Cardiovascular Diseases of the Clinical Hospital Center Osijek in the period from January 1, 2020 to January 1, 2021. The criteria were met by 15 adult respondents. Results: Patients had significantly higher values of LDL-K during infarction compared to controls when the values were closer to the target value of 1.4 mmol/L. In male patients, a significant decrease in LDL-K values can be seen in the control. Values of LDL-K and DLS did not show a linear dependence on age. An equal number of patients were treated with statin monotherapy and dual therapy (statin + ezetimibe). At daily controls, 2 patients were treated with triple therapy (statin, ezetimibe and PCSK9i). There is a significant reduction in LDL-K values in patients who were treated with atorvastatin and in patients on triple therapy. The patients are considered to have DLS, 10/15 patients have possible familial hypercholesterolemia, 3/15 patients have probable hypercholesterolemia, and not a single patient belongs to the definitive disease group. Conclusion: The Dutch Lipid Score is a useful tool in risk assessment for familial hypercholesterolemia and allows the selection of patients who are candidates for triple therapy involving PCSK9 inhibitors. The addition of PCSK9 inhibitors to the therapy resulted in a lowering of LDL cholesterol which allows the achievement of LDL cholesterol target values in patients who have experienced acute myocardial infarction.