prikaz prve stranice dokumenta Flourescencijska in situ hibridizacija u bolesnika s kroničnom limfocitnom leukemijom
  Download
PDF 383.76 KB
undergraduate thesis
Flourescencijska in situ hibridizacija u bolesnika s kroničnom limfocitnom leukemijom
Osijek: Josip Juraj Strossmayer University of Osijek, Faculty of Medicine Osijek, 2022. urn:nbn:hr:152:266081
Vidović, Mia
Josip Juraj Strossmayer University of Osijek
Faculty of Medicine Osijek

Institutional repository: Repository of the Faculty of Medicine Osijek

Cite this document

Vidović, M. (2022). Flourescencijska in situ hibridizacija u bolesnika s kroničnom limfocitnom leukemijom (Undergraduate thesis). Osijek: Josip Juraj Strossmayer University of Osijek, Faculty of Medicine Osijek. Retrieved from https://urn.nsk.hr/urn:nbn:hr:152:266081

Vidović, Mia. "Flourescencijska in situ hibridizacija u bolesnika s kroničnom limfocitnom leukemijom." Undergraduate thesis, Josip Juraj Strossmayer University of Osijek, Faculty of Medicine Osijek, 2022. https://urn.nsk.hr/urn:nbn:hr:152:266081

Vidović, Mia. "Flourescencijska in situ hibridizacija u bolesnika s kroničnom limfocitnom leukemijom." Undergraduate thesis, Josip Juraj Strossmayer University of Osijek, Faculty of Medicine Osijek, 2022. https://urn.nsk.hr/urn:nbn:hr:152:266081

Vidović, M. (2022). 'Flourescencijska in situ hibridizacija u bolesnika s kroničnom limfocitnom leukemijom', Undergraduate thesis, Josip Juraj Strossmayer University of Osijek, Faculty of Medicine Osijek, accessed 07 November 2024, https://urn.nsk.hr/urn:nbn:hr:152:266081

Vidović M. Flourescencijska in situ hibridizacija u bolesnika s kroničnom limfocitnom leukemijom [Undergraduate thesis]. Osijek: Josip Juraj Strossmayer University of Osijek, Faculty of Medicine Osijek; 2022 [cited 2024 November 07] Available at: https://urn.nsk.hr/urn:nbn:hr:152:266081

M. Vidović, "Flourescencijska in situ hibridizacija u bolesnika s kroničnom limfocitnom leukemijom", Undergraduate thesis, Josip Juraj Strossmayer University of Osijek, Faculty of Medicine Osijek, Osijek, 2022. Available at: https://urn.nsk.hr/urn:nbn:hr:152:266081

Metadata
TitleFlourescencijska in situ hibridizacija u bolesnika s kroničnom limfocitnom leukemijom
Title (english)Fluorescence in situ hybridization in patients with chronic lymphocytic leukemia
AuthorMia Vidović
MentorVlatka Periša (mentor)
Committee memberTihana Šimundić (predsjednik povjerenstva)
Committee memberJasminka Milas-Ahić (član povjerenstva)
Committee memberVlatka Periša (član povjerenstva)
GranterJosip Juraj Strossmayer University of Osijek
Faculty of Medicine Osijek
Osijek
Defense date and country2022-09-14, Croatia
Scientific / art field,
discipline and subdiscipline		BIOMEDICINE AND HEALTHCARE
Basic Medical Sciences
Abstract
UVOD: Kronična limfocitna leukemija (KLL) maligna je bolest karakterizirana pojačanim stvaranjem i nakupljanjem zrelih limfocita u koštanoj srži i perifernoj krvi. Flourescencijska in situ hibridizacija (FISH) donijela je vrlo velik preokret u dijagnostici KLL te je dovela do boljeg i jednostavnijeg razumijevanja tijeka ove bolesti i razvoja učinkovitijih terapijskih postupaka. CILJEVI ISTRAŽIVANJA: ispitati zastupljenost citogenetskih promjena kod novodijagnosticiranih pacijenata s KLL dijagnosticiranom u Kliničkom bolničkom centru Osijek, ispitati povezanost citogenetskih promjena kod novodijagnosticiranih pacijenata s KLL s laboratorijskim i demografskim obilježjima. NACRT STUDIJE: presječna studija na povijesnim podatcima ISPITANICI I METODE: Iz medicinskih zapisa prikupljeni su podatci o demografskim, kliničkim i inicijalnim laboratorijskim obilježjima te rezultati FISH analize novodijagnosticiranih pacijenata. Navedeni podatci korišteni su u svrhu identificiranja pacijenata koji ispunjavaju kriterije za uključivanje u istraživanje. REZULTATI: U razdoblju od 1. 1. 2017. do 1. 1. 2021. 61 osobi dijagnosticirana je kronična limfocitna leukemija. Kod 33 pacijenta (54 %) prisutna je citogenetska promjena, po 14 (23 %) bolesnika ima del 13q14.3 ili trisomiju 12, del ATM se bilježi kod 9 (15 %) bolesnika, del p53 ima 5 (8 %) bolesnika, a samo se kod jednog (2 %) nalazi monosomija 12. Nema značajnih razlika u raspodjeli prema spolu i citogenetskoj promjeni, u biokemijskim pokazateljima s obzirom na del 13q14.3, del ATM, del p53 i monosomiju 12. Pacijenti s trisomijom 12 imaju značajno više vrijednosti laktat dehidrogenaze. ZAKLJUČAK: Najčešće prisutne citogenetske promjene kod pacijenata s KLL-om u KBC-u Osijek su delecija 13q14.3 i trisomija 12. Pojavnost citogenetskih promjena slijedi raspodjelu kakva je i u dosad objavljenim svjetskim istraživanjima.
Abstract (english)
INTRODUCTION: Chronic lymphocytic leukemia is a malignant disease characterized by increased production and accumulation of mature lymphocytes in the bone marrow and peripheral blood. Fluorescence in situ hybridization has brought a very big turnaround in the CLL diagnosis and led to a better and simpler understanding of the course of this disease and the development of effective therapeutic procedures. OBJECTIVES: to examine the prevalence of cytogenetic changes in newly diagnosed patients with CLL diagnosed at the Clinical Hospital Center Osijek, to examine the association of cytogenetic changes in newly diagnosed patients with CLL with laboratory and demographic characteristics. STUDY DESIGN: A cross-sectional study on historical data. PARTICIPANTS AND METHODS: Demographic, clinical, and initial laboratory features data were collected from medical records, as well as the results of FISH analysis of newly diagnosed patients. These dana were used to identify patients who meet the criteria for involvement in research. RESULTS: In the period from 1. 1. 2017. to 1. 1. 2021. 61 people were diagnosed with chronic lymphocytic leukemia. In 33 patients (54 %) there is a cytogenetic change, 14 (23 %) patients have del 13q14.3 or trisomy 12, del ATM is recorded in 9 (15 %) patients, del p53 has 5 (8 %) patients, and only one (2 %) has monosomy 12. There are no significant differences in distribution by sex and cytogenetic change in biochemical parameters with respect to del 13q14.3, del ATM, del p53, and monosomy 12, patients with trisomy 12 have significantly higher lactate dehydrogenase levels. CONCLUSION: The most common cytogenetic changes in patients with CLL at the Osijek Clinical Hospital are deletion 13q14.3 and trisomy 12. The occurrence of cytogenetic changes follows the distribution as in the published world studies.
Keywords
Keywords (english)
Languagecroatian
URN:NBNurn:nbn:hr:152:266081
Study programmeTitle: University undergraduate study
Study programme type: university
Study level: undergraduate
Academic / professional title: sveučilišni/a prvostupnik/ prvostupnica (baccalaureus/ baccalaurea) medicinsko laboratorijske dijagnostike (sveučilišni/a prvostupnik/ prvostupnica (baccalaureus/ baccalaurea) medicinsko laboratorijske dijagnostike)
Type of resourceText
File originBorn digital
Access conditionsOpen access
Terms of useLicence In copyright icon
Created on2024-03-08 07:28:19