AIM: To examine frequency and possible difference in the distribution of risk factors according to the default periods. RESPONDENTS AND METHODS: The existing medical documentation from the hospital information system for 100 patients from 1. 3. 2019. – 1. 3. 2021. RESULTS: The groups didn’t differ according to demographic parameters, time of onset of symptoms, type of stroke and mRS. To a large extent, the patients had: hypertension, carotid disease, dyslipidemia, obesity and nearly half of them were smokers. A higher percentage of patients before the pandemic overcame an acute myocardial infarction before stroke, and during diabetes. No significant difference was found among the laboratory findings. The influence of gender on the frequency of risk factors wasn’t found. Patients from the prepandemic period were significantly older with atrial fibrillation and during the pandemic with hypertension. Patients with atrial fibrillation were more likely to have a cardioembolic stroke and an association between TIA and cardioembolic stroke was also observed. Chronic kidney disease, diabetes, hypertension and hyperhomocysteinemia were associated with a poorer treatment outcome. CONCLUSION: A difference was observed in the distribution of risk factors in the observed periods in such a way that acute myocardial infarction was significantly more present in patients before pandemic and diabetes in patients during pandemic. A correlation between the influence of gender on the distribution of risk factors has not been found. In the period before the pandemic, patients with atrial fibrillation were significantly older, and during the pandemic with hypertension. The most common type of stroke in both periods is cardioembolic stroke and in both periods it shows a strong association with atrial fibrillation. Patients in the pre-pandemic period had a significantly worse treatment outcome if they had chronic kidney disease or diabetes, and patients during the pandemic if they had hypertension or hyperhomocysteinemia.