OBJECTIVES: The objectives of this research were to find out how familiar were the students of the Medical faculty in Osijek with the term hospital information system and to find out what their perspective was on that matter. Also, the goal of the research was to find out how familiar the students are with the daily workings of such a system and what it includes. STUDY DESIGN: A cross-sectional study PARTICIPANTS AND METHODS: The participants in this research were the students of the Faculty of Medicine in Osijek, whis includes the Integrated undergraduate and graduate studies in Medicine, Undergraduate studies in Medical Laboratory Diagnostics and Graduate studies in Medical Laboratory Diagnostics. An online questionnaire with a total of 10 questions, divided into two subscales, was used to conduct the research. The first subscale refers to questions about knowledge of the hospital information system, and the second subscale includes students' perception of the importance of the hospital information system. The answers to both subscales are on a 5-point Likert scale. RESULTS: Out of the total number of respondents (40), 31 of them (77%) attended a course related to medical informatics/ bioinformatics during their studies. The majority of the students (75%) believe that better cohesion between medical staff results in more efficient treatment of the patient and 60% of respondents believe that better computerization of the hospital has a positive effect on the work of medical staff. The majority of the students (73%) declare that they do not agree with the statement that they have never heard of a hospital information system. CONCLUSION: We conclude that the students of the Faculty of Medicine in Osijek are well versed in the meaning and significance of the hospital information system and that they have a realistic perception of what such a system includes.