Objectives: To examine factors associated with CPR outcomes in pre-hospital emergency medicine. Study design: Cross-sectional study Participants and methods: the data of patients who underwent cardiopulmonary resuscitation in the period from the beginning of 2021 to the end of 2023 in the area of Vukovar-Srijem County were processed. The exclusive factor was the age of less than 18 years. The influence of the most significant sociodemographic and clinical factors on the success of CPR was examined. Results: 330 patients were included in the study, of which 219 (66,4%) were male. The median age was 67 years. The time interval from the emergency call to the arrival to the patient did not show statistical significance for the outcome of CPR. The presence of eyewitnesses to the arrest was found to be statistically significant, while lay resuscitation was not statistically significant. The state of the airway as well as the method of ventilation did not show significance in the outcome of CPR, while patients with an endotracheal tube as a means of maintaining the airway had the best CPR outcome. The highest percentage of successful ROSC was found in subjects whose initial heart rhythm was VF, while patients with asystole had the lowest success. There was no difference in the outcome of CPR and type of vascular access. The time of the first defibrillation and the number of defibrillations did not show statistical significance for the success of CPR. Larger amounts of adrenaline were a predictor of a negative CPR outcome. In the CPR negative outcome model, the supraglottic device and trauma as the cause of arrest decreased the likelihood of a negative outcome, while shockable rhythms and higher amounts of adrenaline increased the risk. Conclusion: The factors that most influenced the outcome of CPR were: the presence of eyewitnesses to the cardiac arrest, the initial heart rhythm, the method of maintaining the airway, and the use of adrenaline.