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undergraduate thesis
Ispitivanje genotoksičnog učinka terpentina primjenom mikronukleus testa
Osijek: Josip Juraj Strossmayer University of Osijek, Faculty of Medicine, 2017. urn:nbn:hr:152:451740
Kević Dešić, Sara
Josip Juraj Strossmayer University of Osijek
Faculty of Medicine Osijek

Institutional repository: Repository of the Faculty of Medicine Osijek

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Kević Dešić, S. (2017). Ispitivanje genotoksičnog učinka terpentina primjenom mikronukleus testa (Undergraduate thesis). Osijek: Josip Juraj Strossmayer University of Osijek, Faculty of Medicine Osijek. Retrieved from https://urn.nsk.hr/urn:nbn:hr:152:451740

Kević Dešić, Sara. "Ispitivanje genotoksičnog učinka terpentina primjenom mikronukleus testa." Undergraduate thesis, Josip Juraj Strossmayer University of Osijek, Faculty of Medicine Osijek, 2017. https://urn.nsk.hr/urn:nbn:hr:152:451740

Kević Dešić, Sara. "Ispitivanje genotoksičnog učinka terpentina primjenom mikronukleus testa." Undergraduate thesis, Josip Juraj Strossmayer University of Osijek, Faculty of Medicine Osijek, 2017. https://urn.nsk.hr/urn:nbn:hr:152:451740

Kević Dešić, S. (2017). 'Ispitivanje genotoksičnog učinka terpentina primjenom mikronukleus testa', Undergraduate thesis, Josip Juraj Strossmayer University of Osijek, Faculty of Medicine Osijek, accessed 28 November 2024, https://urn.nsk.hr/urn:nbn:hr:152:451740

Kević Dešić S. Ispitivanje genotoksičnog učinka terpentina primjenom mikronukleus testa [Undergraduate thesis]. Osijek: Josip Juraj Strossmayer University of Osijek, Faculty of Medicine Osijek; 2017 [cited 2024 November 28] Available at: https://urn.nsk.hr/urn:nbn:hr:152:451740

S. Kević Dešić, "Ispitivanje genotoksičnog učinka terpentina primjenom mikronukleus testa", Undergraduate thesis, Josip Juraj Strossmayer University of Osijek, Faculty of Medicine Osijek, Osijek, 2017. Available at: https://urn.nsk.hr/urn:nbn:hr:152:451740

Metadata
TitleIspitivanje genotoksičnog učinka terpentina primjenom mikronukleus testa
Title (english)Evaluation of genotoxicity of turpentine through micronuclei test
AuthorSara Kević Dešić
MentorJasenka Wagner (mentor)
Committee memberMarija Heffer (predsjednik povjerenstva)
Committee memberMartina Smolić (član povjerenstva)
Committee memberJasenka Wagner (član povjerenstva)
GranterJosip Juraj Strossmayer University of Osijek
Faculty of Medicine Osijek
Osijek
Defense date and country2017-09-26, Croatia
Scientific / art field,
discipline and subdiscipline		BIOMEDICINE AND HEALTHCARE
Basic Medical Sciences
Human Genetics, Genomics and Proteomics
Abstract
Cilj istraživanja: Cilj ovog istraživanja bio je ispitati genotoksični učinak terpentina i odrediti indeks proliferacije limfocita periferne krvi zaustavljanjem citokineze kod ljudi profesionalno izloženih terpentinu. Nacrt studije:Kohortna studija. Ispitanici i metode: Analizirani su limfociti 22 ispitanika koji svakodnevno koriste terpentin u radu, te limfociti 20 kontrolnih ispitanika. Bilježen je ukupan broj MN, broj nukleoplazmatskih mostova (NPM) i nuklearnih pupova (NP) te indeks proliferacije stanica (CBPI). Rezultati: Terpentin uzrokuje statistički značajno povećani broj mikronukleusa, nukleoplazmatskih mostova i nuklearnih pupova, te značajnu citotoksičnost (Mann-Whitney U-test, P<0,05). Genotoksičnost i citotoksičnost terpentina povećavaju se sa vremenom izlaganja (Kruskal-Wallis test, P<0,05). Zaključak: Pokazano je da je mikronukleus test vrlo dobar pokazatelj genotoksičnog i citotoksičnog djelovanja terpentina.
Abstract (english)
Objectives: The aim of this research was to examine the genotoxic effect of turpentine, and to determine the proliferation index of peripheral blood lymphocytes by cytokinesis, in people professionally exposed to turpentine. Study design: Cohort study Participants and methods: The lymphocytes of 22 participants, who are daily exposed, through their work to turpentine were analyzed. The same procedure was followed for 20 participants in the control group. The total number of micronuclei, nucleoplasmic bridges and nuclear buds as well as cell proliferation index were recorded. Results: Turpentine causes a significant increase in number of micronuclei and significant citotoxicity -(Mann-Whitney U test, P<0,05). Genotoxicity and citotoxicity of turpentine rise through extended time period of exposure -(Kruskal-Wallis test, P<0,05). Conclusion: It was proven that micronucleus test is a very good indicator of genotoxic and cytotoxic action of turpentine.
Keywords
Keywords (english)
Languagecroatian
URN:NBNurn:nbn:hr:152:451740
Study programmeTitle: University undergraduate study
Study programme type: university
Study level: undergraduate
Academic / professional title: sveučilišni prvostupnik/prvostupnica (baccalaureus/ baccalaurea) medicinske laboratorijske dijagnostike (sveučilišni prvostupnik/prvostupnica (baccalaureus/ baccalaurea) medicinske laboratorijske dijagnostike)
Type of resourceText
File originBorn digital
Access conditionsOpen access
Terms of useLicence In copyright icon
Created on2018-04-10 09:35:24