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undergraduate thesis
Citodijagnostika benignih promjena u dojci
Osijek: Josip Juraj Strossmayer University of Osijek, Faculty of Medicine, 2017. urn:nbn:hr:152:367608
Dener, Ena
Josip Juraj Strossmayer University of Osijek
Faculty of Medicine Osijek

Institutional repository: Repository of the Faculty of Medicine Osijek

Cite this document

Dener, E. (2017). Citodijagnostika benignih promjena u dojci (Undergraduate thesis). Osijek: Josip Juraj Strossmayer University of Osijek, Faculty of Medicine Osijek. Retrieved from https://urn.nsk.hr/urn:nbn:hr:152:367608

Dener, Ena. "Citodijagnostika benignih promjena u dojci." Undergraduate thesis, Josip Juraj Strossmayer University of Osijek, Faculty of Medicine Osijek, 2017. https://urn.nsk.hr/urn:nbn:hr:152:367608

Dener, Ena. "Citodijagnostika benignih promjena u dojci." Undergraduate thesis, Josip Juraj Strossmayer University of Osijek, Faculty of Medicine Osijek, 2017. https://urn.nsk.hr/urn:nbn:hr:152:367608

Dener, E. (2017). 'Citodijagnostika benignih promjena u dojci', Undergraduate thesis, Josip Juraj Strossmayer University of Osijek, Faculty of Medicine Osijek, accessed 27 November 2024, https://urn.nsk.hr/urn:nbn:hr:152:367608

Dener E. Citodijagnostika benignih promjena u dojci [Undergraduate thesis]. Osijek: Josip Juraj Strossmayer University of Osijek, Faculty of Medicine Osijek; 2017 [cited 2024 November 27] Available at: https://urn.nsk.hr/urn:nbn:hr:152:367608

E. Dener, "Citodijagnostika benignih promjena u dojci", Undergraduate thesis, Josip Juraj Strossmayer University of Osijek, Faculty of Medicine Osijek, Osijek, 2017. Available at: https://urn.nsk.hr/urn:nbn:hr:152:367608

Metadata
TitleCitodijagnostika benignih promjena u dojci
Title (english)Benign breast disease cytodiagnosis
AuthorEna Dener
MentorBranka Lončar (mentor)
Committee memberKsenija Marjanović (predsjednik povjerenstva)
Committee memberBiljana Pauzar (član povjerenstva)
Committee memberBranka Lončar (član povjerenstva)
GranterJosip Juraj Strossmayer University of Osijek
Faculty of Medicine Osijek
Osijek
Defense date and country2017-09-20, Croatia
Scientific / art field,
discipline and subdiscipline		BIOMEDICINE AND HEALTHCARE
Basic Medical Sciences
Cytology, Histology and Embryology
Abstract
CILJ ISTRAŽIVANJA: Procijeniti dijagnostičku vrijednost citologije benignih promjena u dojci usporedbom s patohistološkim nalazom određivanjem specifičnosti i negativne prediktivne vrijednosti. USTROJ STUDIJE: Presječna studija. ISPITANICI I METODE: Istraživanjem su obuhvaćeni ispitanici u kojih je na Kliničkom zavodu za kliničku citologiju Kliničkog bolničkog centra Osijek od 1. siječnja do 31. prosinca 2015. godine učinjena citološka punkcija palpabilne i ultrazvukom vođene punkcije nepalpabilne tvorbe u dojci te postavljena dijagnoza C2 ili C3 kategorije citološkog nalaza. Analizirani razmazi su fiksirani na zraku i bojeni standardnom May-Grünwald metodom. Kao izvor podataka korištena je baza citoloških nalaza Kliničkog zavoda za kliničku citologiju. U istraživanje su uključeni i patohistološki nalazi ispitanika koji su dobiveni biopsijom ili ekstirpacijom promjene koja je prethodno citološki punktirana. REZULTATI: Benigne promjene u dojci raspodijeljene su u 5 kategorija citoloških nalaza. Benignim kategorijama (C2 i C3) označeno je 665 (66,1 %) uzoraka, 78 palpabilnih i 587 nepalpabilnih tvorbi, u 558 ispitanika. Fibroadenomi i ciste su najčešće dijagnosticirane benigne promjene u dojci i to u 158 (23,8 %) i 142 (21,5 %) uzorka. Usporedbom citološkog i patohistološkog nalaza nađena su 2 (3,3 %) lažno negativna nalaza i 6 (10 %) lažno pozitivna nalaza. U 52 (86,7 %) ispitanika točno je postavljena dijagnoza benigne promjene. Specifičnost citološkog nalaza benignih promjena u dojci iznosi 89,6 %, a negativna prediktivna vrijednost 96,3 %. ZAKLJUČAK: Citološka je punkcija neinvazivna, brza i jeftina dijagnostička metoda koja usmjerava dijagnostičku obradu. Kako većina benignih lezija nije povezana s rizikom za nastanak raka dojke, trebalo bi izbjegavati nepotrebne kirurške postupke.
Abstract (english)
OBJECTIVE: The aim of this study was to determine diagnostic value of cytology in benign breast changes by comparing them with pathohistological findings to determine their specificity and negative predictive value. STUDY DESIGN: A cross-sectional study. PARTICIPANS AND METHODS: This study included respondents who underwent cytological puncture od palpable and non-palpable mass in breast and set diagnosis C2 or C3 category from January 1st, 2015 until December 31st, 2015 at Clinical institute for clinical cytology at Clinical Hospital Centre Osijek. Analysed smears were fixed in the air and coloured with May-Grünwald method. Cytological findings of Clinical institute for clinical cytology were used as source of data in this study. This research also included pathohistological findings of participants got in biopsy or extirpation of previously punctured change. RESULTS: Benign changes in breast are distributed in 5 categories of cytological findings. In benign categories (C2 and C3) belong 665 (66.1%) changes, 78 palpable and 587 non-palpable in 558 participants, 19 male and 539 female. Fibroadenoma and cysts are the most commonly diagnosed benign changes in breast in 158 (23.8%) and 142 (21.5%) samples. In comparison of cytological and pathohistological findings 2 (3.3%) were found false negative and 6 (10%) false positive. In 52 (86.7%) participants diagnosis was correct for benign changes. Specificity of cytological findings in benign breast diseases is 89.6% and negative predictive value is 96.3%. CONCLUSION: Cytological puncture is non-invasive, fast and inexpensive technique that directs the diagnostic treatment. Because of majority of benign lesions are not associated with an increased risk for breast cancer, unnecessary surgical procedures should be avoided.
Keywords
Keywords (english)
Languagecroatian
URN:NBNurn:nbn:hr:152:367608
Study programmeTitle: University undergraduate study
Study programme type: university
Study level: undergraduate
Academic / professional title: sveučilišni prvostupnik/prvostupnica (baccalaureus/ baccalaurea) medicinske laboratorijske dijagnostike (sveučilišni prvostupnik/prvostupnica (baccalaureus/ baccalaurea) medicinske laboratorijske dijagnostike)
Type of resourceText
File originBorn digital
Access conditionsOpen access
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Created on2018-04-10 09:39:47