Title Osobitosti bolesti štitnjače u dječjoj dobi Title (english) Characteristics of Thyroid Disease in Childhood Author Anja Tomić Mentor Silvija Pušeljić (mentor)Committee member Vesna Milas (predsjednik povjerenstva)Committee member Tatjana Bačun (član povjerenstva)Committee member Silvija Pušeljić (član povjerenstva)Granter Josip Juraj Strossmayer University of Osijek Defense date and country 2018-09-18, Croatia Scientific / art field, BIOMEDICINE AND HEALTHCARE Abstract Autoimune bolesti su u porastu u svijetu. U posljednjem desetljeću došlo je do porasta incidencije autoimunih bolesti štitnjače u dječjoj dobi. Cilj: Cilj rada bio je utvrditi incidenciju bolesti štitnjače u populaciji djece liječene u Klinici za pedijatriju KBC-a Osijek, utvrditi je li došlo do povećanja incidencije bolesti štitnjače u dječjoj dobi u 2017. godini u odnosu na 2010. godinu te utvrditi postoji li povezanost pojedinih čimbenika poput anamnestičkih osobitosti, dobi, spola, hormonskog statusa, komorbiditeta i drugih relevantnih podataka uz povećanu incidenciju bolesti štitnjače u dječjoj dobi za dani period Nacrt studije: dvogodišnja retrospektivna studija u dva odvojena promatrana jednogodišnja razdoblja (2010. i 2017. godina). Ispitanici i metode: U istraţivanje su uključeni svi pedijatrijski pacijenti Zavoda za endokrinologiju KBC-a Osijek s dijagnozom bolesti štitnjače obraĎivani u periodu od 01.01.2010. do 31.12.2010. godine te od 01.01.2017 do 31.12.2017. godine, e, a za dobivanje podataka korištena je medicinska dokumentacija. Razlike meĎu varijablama ispitane su pomoću χ2 testa, Fisherovog egzaktnog testa i Mann-Whitneyjevog U testa, a razina statističke značajnosti prihvaćena je za p < 0,05. Rezultati: Došlo je do 2.4 većeg porasta incidencije bolesti štitnjače, 9.7 puta većeg porasta incidencije autoimunih tireoiditisa, 9.75 puta većeg porasta incidencije nespecificirane hipotireoze, trostrukog porasta u incidenciji netoksične strume, a o ostale neklasificirane bolesti štitnjače su takoĎer u statistički značajnom porastu. Analizom pojedinih čimbenika poput anamnestičkih osobitosti, dobi, spola, hormonskog statusa, komorbiditeta i drugih relevantnih podataka ne moţe se objasniti povećana incidencija bolesti štitnjače. Zaključak: Incidencija bolesti štitnjače uvjerljivo je porasla u posljednjih 7 godina prateći svjetska kretanja. Potrebno je uloţiti napore kako bi se u potpunosti razjasnio patofiziološki mehanizam nastanka bolesti i pojedinih čimbenika koji dovode do povećane incidencije bolesti štitnjače, što bi potencijalno moglo dovesti do razvoja čitavog spektra naprednijih terapijskih i dijagnostičkih mogućnosti.
Abstract (english) Autoimmune diseases are on the rise worldwide. In the last decade an increase of incidence of autoimmune thyroid disease in children has been observed. Objective: The aim of the study was to determine the incidence of thyroid disease in the pediatric population treated at the Pediatric Clinic of Osijek; to determine if there was a rise of thyroid disease incidence in pediatric population in 2010 and 2017; and to determine whether there was any association with certain factors such as anamnestic features, age, gender, hormonal status, comorbidity, and other relevant factors with an increased incidence of thyroid disease in childhood for a given period. Draft study: two-year retrospective study in two separately observed one-year periods (2010 and 2017) Patients and Methods: All pediatric patients of the Institute for Endocrinology of KBC Osijek with diagnosed thyroid disease were included in the study in the period from January 1st 2010 until December 31st 2010 and from January 1st 2017 until December 31st 2017, and medical data were used to obtain the data. Differences between variables were tested by χ2 test, Fisher's exact test, and Mann-Whitney's U test, and the level of statistical significance was accepted for p <0.05. Results: There was a 2.4-fold increase in thyroid disease approximated incidence, 9.7-fold higher approximated incidence of autoimmune thyroiditis, 9.75-fold higher approximated incidence of unspecified hypothyroidism, triple increase in approximated incidence of non-toxic goitre, and other unclassified thyroid diseases are also statistically significantly on the rise. Analysis of factors such as anamnestic features, age, gender, hormonal status, comorbidity, and other relevant data can not explain the increase of thyroid disease incidence. Conclusion: The incidence of thyroid disease has increased considerably in the last 7 years, following world trends. Efforts should be taken to clarify the mechanisms and factors involved causing thyroid diseases in the pediatric populations. Early detection and evaluation of the disease should be stressed to prevent the development of further complications.
Keywords
bolesti štitnjače
pedijatrija
incidencija
autoimunost
Keywords (english)
thyroid disease
pediatrics
incidence
autoimmunity
Language croatian URN:NBN urn:nbn:hr:152:325530 Study programme Title: University Graduate Studies Type of resource Text File origin Born digital Access conditions Open access Terms of use Created on 2018-12-05 13:09:26
