Objectives: To examine the usefulness of Hospital Information System (BIS) in nursing work with surgical patients. Furthermore, to examine the differences in assessing the usefulness of BIS with regard to the age of the respondents, the length of their vocational work experience, and self-evaluation of their ability level to use information technology. Study design: Cross-sectional research. Subjects and Methods: Subjects are nurses directly involved in the process of health care of surgical patients at the Clinic for Surgery, University Hospital Centre Osijek. An anonymous questionnaire, specially designed for this research, was used as an instrument of the investigation. Standard statistical methods have been used, and the significance level was set to P = 0,05. Results: The survey was conducted on 63 respondents at the Clinic for Surgery, University Hospital Centre Osijek, out of which 6 (9 %) were male and 57 (91 %) female nurses. On administration and documentation updating, 34 (54 %) respondents state that they spend 25 – 49% of their working hours. Only 4 (6 %) respondents state that BIS is well structured according to the requirements of the health care of surgical patients; and respondents who are 30 years of age and younger agree significantly more with the claim that the data entered in BIS are correct. Out of 39 (62 %) respondents who stated that the data entered in BIS are objective, significantly more of them have a work experience of up to 10 years. Conclusion: Hospital Information System, as a tool for nursing work with surgical patients, is only partly usable. Younger nurses are documenting their work accurately and objectively. Higher educated nurses with advanced computer literacy have more developed responsibility and use all aspects of electronic documentation in their quest for adequate work solutions.