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Utjecaj akutne i intermitentne hiperbarične oksigenacije na izražaj proteina HIF-1 alfa u krvnim žilama Sprague-Dawley štakora
Osijek: Josip Juraj Strossmayer University of Osijek, Faculty of Medicine, 2018. urn:nbn:hr:152:619101
Pavlović, Ana
Josip Juraj Strossmayer University of Osijek
Faculty of Medicine Osijek

Institutional repository: Repository of the Faculty of Medicine Osijek

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Pavlović, A. (2018). Utjecaj akutne i intermitentne hiperbarične oksigenacije na izražaj proteina HIF-1 alfa u krvnim žilama Sprague-Dawley štakora (Undergraduate thesis). Osijek: Josip Juraj Strossmayer University of Osijek, Faculty of Medicine Osijek. Retrieved from https://urn.nsk.hr/urn:nbn:hr:152:619101

Pavlović, Ana. "Utjecaj akutne i intermitentne hiperbarične oksigenacije na izražaj proteina HIF-1 alfa u krvnim žilama Sprague-Dawley štakora." Undergraduate thesis, Josip Juraj Strossmayer University of Osijek, Faculty of Medicine Osijek, 2018. https://urn.nsk.hr/urn:nbn:hr:152:619101

Pavlović, Ana. "Utjecaj akutne i intermitentne hiperbarične oksigenacije na izražaj proteina HIF-1 alfa u krvnim žilama Sprague-Dawley štakora." Undergraduate thesis, Josip Juraj Strossmayer University of Osijek, Faculty of Medicine Osijek, 2018. https://urn.nsk.hr/urn:nbn:hr:152:619101

Pavlović, A. (2018). 'Utjecaj akutne i intermitentne hiperbarične oksigenacije na izražaj proteina HIF-1 alfa u krvnim žilama Sprague-Dawley štakora', Undergraduate thesis, Josip Juraj Strossmayer University of Osijek, Faculty of Medicine Osijek, accessed 26 November 2024, https://urn.nsk.hr/urn:nbn:hr:152:619101

Pavlović A. Utjecaj akutne i intermitentne hiperbarične oksigenacije na izražaj proteina HIF-1 alfa u krvnim žilama Sprague-Dawley štakora [Undergraduate thesis]. Osijek: Josip Juraj Strossmayer University of Osijek, Faculty of Medicine Osijek; 2018 [cited 2024 November 26] Available at: https://urn.nsk.hr/urn:nbn:hr:152:619101

A. Pavlović, "Utjecaj akutne i intermitentne hiperbarične oksigenacije na izražaj proteina HIF-1 alfa u krvnim žilama Sprague-Dawley štakora", Undergraduate thesis, Josip Juraj Strossmayer University of Osijek, Faculty of Medicine Osijek, Osijek, 2018. Available at: https://urn.nsk.hr/urn:nbn:hr:152:619101

Metadata
TitleUtjecaj akutne i intermitentne hiperbarične oksigenacije na izražaj proteina HIF-1 alfa u krvnim žilama Sprague-Dawley štakora
Title (english)The effect of high salt dietary intake on leukocytes' distribution and activation in female Sprague-Dawley rats
AuthorAna Pavlović
MentorInes Drenjančević (mentor)
Committee memberAleksandar Kibel (predsjednik povjerenstva)
Committee memberIvana Jukić (član povjerenstva)
Committee memberInes Drenjančević (član povjerenstva)
GranterJosip Juraj Strossmayer University of Osijek
Faculty of Medicine Osijek
Osijek
Defense date and country2018-09-26, Croatia
Scientific / art field,
discipline and subdiscipline		BIOMEDICINE AND HEALTHCARE
Basic Medical Sciences
Abstract
Cilj: Utvrditi izražajnost proteina HIF-1α kod akutne i intermitentne izloženosti hiperbaričnoj oksigenaciji (HBO₂) na modelu zdravih Sprague-Dawley štakora. Materijali i metode: Zdravi Sprague-Dawley štakori, starosti 9 – 11 tjedana, podijeljeni su u četiri skupine (KONTROLA, A-HBO₂, 24H-HBO₂ i 4D-HBO₂). Kontrolna skupina nije bila izložena djelovanju HBO₂. Akutnom djelovanju HBO₂ izložene su skupine A-HBO₂ (žrtvovani odmah nakon izlaganja) i 24H-HBO₂ (žrtvovani 24 h nakon izlaganja), dok je intermitentnom djelovanju HBO₂ bila izložena 4D-HBO₂ skupina štakora. Izražaj HIF-1α proteina odreĎen je na uzorcima torakalne aorte SD štakora uz pomoć Western blot metode. Rezultati: Izražaj HIF-1α proteina statistički je značajno povećan u 24H-HBO₂ i 4D-HBO₂ skupinama u usporedbi s kontrolnom skupinom. Zaključak: Akutno i intermitentno izlaganje hiperbaričnoj oksigenaciji potiče izražajnost HIF-1α proteina
Abstract (english)
Aim: The aim of this study was to determine the expression of HIF-1α protein in acute and intermittent exposure to hyperbaric oxygenation (HBO₂) in healthy Sprague-Dawley rats. Materials and Methods: Healthy Sprague-Dawley rats, 9 - – 11 weeks old, were divided into four groups (CONTROL, A-HBO₂, 24H-HBO₂ i 4D-HBO₂). The control group was not exposed to HBO₂. A-HBO₂ (sacrificed immediately after the exposure) and 24H-HBO₂ (sacrificed 24 hours after the exposure) rats were exposed to the acute HBO₂, while 4D-HBO₂ rats were exposed to the intermittent HBO₂. The expression of HIF-1α protein was determined on thoracic aorta samples of SD rats by the Western blot method. Results: The expression of HIF-1α protein was statistically significantly increased in 24H-HBO₂ and 4D-HBO₂ groups in comparison to the control group. Conclusion: Acute and intermittent exposure to hyperbaric oxygenation induces HIF-1α protein expression.
Keywords
Keywords (english)
Languagecroatian
URN:NBNurn:nbn:hr:152:619101
Study programmeTitle: University undergraduate study
Study programme type: university
Study level: undergraduate
Academic / professional title: sveučilišni prvostupnik/prvostupnica (baccalaureus/ baccalaurea) medicinske laboratorijske dijagnostike (sveučilišni prvostupnik/prvostupnica (baccalaureus/ baccalaurea) medicinske laboratorijske dijagnostike)
Type of resourceText
File originBorn digital
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Created on2019-01-08 10:03:50