Objectives: The aim of the study is to investigate the clinical knowledge of pharmacy and medical students in determining drug-related problems. Material and methods: The research was conducted among students of pharmacy and medicine at the University of Split School of Medicine. A Survey on Drug-Related Problems based on 9 clinical cases with multiple choice offered (40 claims in total) was used for the study. The research was conducted online via the Google Forms tool due to epidemiological situations caused by the COVID-19 epidemic. Respondents assessed the relevance or appropriateness of each statement using the seven-point Likert scale. Compared to the original version of the survey, questions about chronic illness, drug use, drug side effects, and other drug-related issues were added. The proposed statements aimed to assess the ability to identify, gather relevant information on DRPs and make appropriate recommendations to address them. Each statement was appropriately evaluated and the maximum score was 80 and the minimum was 0. The survey results are presented as integers and percentages, i.e., media and interquartile ranges, depending on where they were appropriate. The total number of points between students of individual studies and between students of individual years of study was compared by Kruskal-Wallis test while the level of statistical significance was set at p <0,05. Results: A total of 101 students participated in the research on drug-related problems. The majority of the respondents included were female, and the third of the respondents were medical students. The median level of clinical knowledge of pharmacy students was 39 (30-44), medical student 39 (33-47), and no statistically significant difference was found between these two groups. However, a statistically significant difference was found between the 4th and 5th year of study of pharmacy students, with the corresponding median 28.5 (26-38.5) and 41 (38-49), p <0,001. No difference was found between the 5th and 6th year of medical studies. Conclusion: The study revealed a significant difference in the level of clinical knowledge in determining drug-related problems among subjects in the 4th and 5th year of the study of pharmacy. Students of the 5th year of pharmacy achieved better results than students of the 4th year of pharmacy. Research has shown that there is no significant difference in clinical knowledge about DRPs among pharmacy and medicine students. Research has shown that there is no significant difference in clinical knowledge between the 5th and 6th year of medical studies. The importance of a higher level of education and improvement of competencies in order to more successfully identify, prevent and address DRPs was determined.