| Abstract | Cilj istraživanja: Cilj ovog istraživanja je ispitati incidenciju urotelnih karcinoma mokraćnog mjehura (Ta, T1, cis) u 3 dalmatinske županije te utvrditi potencijalne razlike u rezultatima na temelju različitih parametara.
Ispitanici i metode: Provedeno istraživanje uključilo je 1058 pacijenata kojima je u razdoblju od 2011. do 2015. godine postavljena dijagnoza primarnog urotelnog karcinoma mokraćnog mjehura (NMIBC, od engl. non-muscle invasive bladder cancer) te su liječeni u KBC Split, OB Zadar ili OB Šibenik. Podaci o spolu, starosti, godini dijagnoze, gradusu, postojanju recidiva i broju recidiva u promatranom razdoblju, prikupljeni su iz arhive KBC Split, OB Zadar i OB Šibenik. Podaci su potom uneseni u bazu podataka u kojoj su statističkim funkcijama i analizirani.
Rezultati: Analizom podataka o pacijentima utvrdili smo da ne postoji statistički značajna razlika u udjelu oboljelih prema spolu između 3 promatrane dalmatinske bolnice. Oboljele smo podijelili u 6 dobnih skupina temeljem kojih smo utvrđivali incidenciju bolesti prema starosti. Najveći broj pacijenata pripada dobnoj skupini 70 – 79 godina. Medijan starosti pacijenta oboljelog od urotelnog karcinoma mokraćnog mjehura je 69 godina. Promatrajući pojavu recidiva bolesti u 3 promatrana centra (KBC Split, OB Zadar, OB Šibenik) nije utvrđena statistički značajna razlika između pacijenata Zadarske i Šibensko-kninske županije, dok je u Splitsko-dalmatinskoj statistički značajno više nerecidivirajućih u odnosu na recidvirajuće tumore (P<0,001). Značajna razlika u rezultatima potvrđena je analizom pacijenata prema gradusu primarne dijagnoze u sve 3 bolnice i to tako da je najveća incidencija karcinoma visokog gradusa u Zadarskoj županiji, a najveća incidencija karcinoma niskog gradusa u Šibensko-kninskoj županiji (P<0,001).
Zaključak: Nije utvrđena statistički značajna razlika u incidenciji urotelnog karcinoma mokraćnog mjehura između promatrane 3 dalmatinske županije, ali je utvrđena razlika prema gradusu karcinoma i djelomično prema recidiviranju karcinoma. Dobiveni rezultati pokazuju dobru usporedivost sa stranim kohortnim studijama na temu recidiva urotelnih karcinoma mokraćnog mjehura. |
| Abstract (english) | Aim of the study: The aim of this study was to investigate the incidence of urothelial bladder cancer (Ta, T1, cis) in 3 Dalmatian counties and to determine potential differences in results based on different parameters.
Patients and methods: The study included 1058 patients who were diagnosed with primary urothelial bladder cancer (non-muscle invasive bladder cancer, NMIBC) in the period from 2011 to 2015 and were treated at Split University Clinical Hospital Center (KBC Split), General Hospital Zadar (OB Zadar), General Hospital Šibenik (OB Šibenik). Data on sex, age, year of diagnosis, gradus, recurrence and number of recurrences in the observed period were collected from the archives of KBC Split, OB Zadar and OB Šibenik. The data were listed into a database and then statistically analyzed.
Results: There was no statistically significant difference in the proportion of patients with NMIBC by sex, in 3 Dalmatian hospitals. We have divided patients into 6 groups by age, which we used to determine the incidence of the disease according to age. The biggest number of patients belongs to the age group of 70 – 79 years. The median age of a patient with urothelial bladder cancer is 69 years. Observing the occurrence of disease recurrence in 3 observed centers (KBC Split, OB Zadar, OB Šibenik) no statistically significant difference was detected between patients from OB Zadar and OB Šibenik, while in KBC Split there was statistically significantly higher incidence of non recurrent, compared to recurrent tumors (P<0,001) . A significant difference was confirmed by the analysis of patients according to the gradus of primary diagnosis of urothelial bladder cancers in all 3 observed hospitals. The highest incidence of high grade cancer was found in OB Zadar, while the highest incidence of low grade cancer was found in OB Šibenik (P<0,001).
Zaključak: No statistically significant difference was found in the incidence of urothelial bladder cancer, patient sex or age, between the observed 3 Dalmatian counties, but statistical significance in the carcinoma gradus and partial significance in tumor recurrence, was observed. The obtained results show good comparability with foreign cohort studies on the recurrence of urothelial bladder cancer. |
