Title Povezanost sastava tijela s rizikom prijeloma u postmenopauzalnih žena Title (english) Relationship between body composition and fracture risk in postmenopausal women Author Ružica Brešić Mentor Tina Tičinović Kurir (mentor)Committee member Joško Božić (predsjednik povjerenstva)Committee member Anela Novak (član povjerenstva)Committee member Marino Vilović (član povjerenstva)Granter University of Split Defense date and country 2021, Croatia Scientific / art field, BIOMEDICINE AND HEALTHCARE Abstract Cilj istraživanja: Cilj istraživanja je usporediti parametre koštane snage i rizik za prijelom u postmenopauzalnih žena sa postotkom tjelesne masti većim od 32% u odnosu na postmenopauzalne žena sa postotkom tjelesne masti manjim od 32% .
Materijali i metode: Istraživanje je provedeno u Regionalnom centru za dijabetes, endokrinologiju i bolesti metabolizma Kliničkog bolničkog centra Split. Podatci su prikupljani u razdoblju od 11. siječnja do 8. ožujka 2021. godine. U istraživanju je sudjelovalo 50 postmenopauzalnih žena. Ispitanice su podijeljene u dvije skupine ovisno o postotku tjelesne masti. Prvu skupinu je činilo 38 ispitanica koje su imale postotak tjelesne masti veći od 32 %, a kontrolnu skupinu 12 ispitanica s postotkom tjelesne masti manjim od 32 %. Sve uključene ispitanice su anketirane za vrijeme redovnih pregleda, izmjeren je sastav tijela, te je korišten nalaz denzitometrije iz kojih je izračunat FRAX i nalaz TBS-a.
Rezultati: BMD za vrat bederne kosti i BMD za kralješke od L1 do L4 su bili statistički značajno veći u skupini bolesnica sa većim postotkom tjelesne masti u usporedbi s kontrolnom skupinom (P=0,013, P=0,002). Usporedbom prosječnih T vrijednosti pronađena je statistički značajna veća T vrijednost u skupini bolesnica s većim postotkom tjelesne masti za T vrijednost kuka (P=0,004), T vrijednost vrata bedrene kosti (P=0,014) i T vrijednost za kralješke od L1 do L4 (P=0,006). Nije pronađena statistički značajna razlika u mikroarhitekturi kosti procijenjenoj TBS-om između ispitivanih skupinama (P=0,218). Desetogodišnji rizik prijeloma kuka izračunat pomoću FRAX-a je značajno manji u postmenopauzalnih žena s većim postotkom masnog tkiva (P=0,047) dok nije nađena statistički značajna razlika za rizik velikog osteoporotičnog prijeloma između ispitivanih skupina (P=0,084) ni u vrijednostima dobivenim pomoću FRAX-a prilagođenog s TBS-om ( P=0,195) .
Zaključak: Ovo istraživanje je pokazalo da postmenopauzalne žene sa postotkom tjelesne masti većim od 32 % imaju bolje parametare koštane snage i manji rizik prijeloma kuka u odnosu na postmenopauzalne žene sa postotkom tjelesne masti manjim od 32 %.
Abstract (english) Aim: The aim of the study was to compare bone strength and fracture risk parameters in postmenopausal women with a body fat percentage higher than 32% compared to postmenopausal women with a body fat percentage lower than 32%.
Materials and methods: The study was conducted at the Regional Center for Diabetes, Endocrinology and Metabolic Diseases of the University Hospital of Split. Data were collected in the period from January 11 until March 8, 2021. Fifty postmenopausal women participated in the study. The subjects were divided into two groups depending on the body fat percentage. The first group consisted of 38 subjects whose body fat percentage was higher than 32%, and the control group consisted of 12 subjects whose body fat percentage was lower than 32%. All included subjects were interviewed during regular examinations, body composition was measured, and densitometry findings were used from which FRAX and TBS findings were calculated.
Results: BMD for femoral neck and BMD for vertebrae from L1 to L4 were statically significantly higher in the group of patients with higher percentage of body fat compared to the control group (P=0.013, P=0.002). Comparing the average T scores, a statistically significant higher T score was found in the group of patients with higher percentage of body fat in T score for hip (P=0.004), femoral neck (P=0.014) and T score for vertebrae from L1 to L4 (P = 0.006). No statistically significant difference was found in the bone microarchitecture estimated by TBS between the examined groups (P=0.219), statistically significant difference was not found for the risk of major osteoporotic fracture between the examined groups (P=0.084) nor in the values obtained by FRAX adjusted by TBS (P=0.195).
Conclusion: This study showed that postmenopausal women with a body fat percentage greater than 32% have better bone strength parameters and a lower risk of hip fracture compared to postmenopausal women with a body fat percentage less than 32%.
Keywords
Postmenopauzalna osteoporoza
Osteoporotski prijelomi
Čimbenici rizika
Sastav tijela
Masno tkivo
Keywords (english)
Osteoporosis Postmenopausal
Osteoporotic Fractures
Risk Factors
Body Composition
Adipose Tissue
Language croatian URN:NBN urn:nbn:hr:171:538197 Study programme Title: Medicine Type of resource Text File origin Born digital Access conditions Open access Terms of use Created on 2021-07-27 07:30:17
