| Abstract | Cilj istraživanja: Cilj ovog istraživanja bio je ispitati strukturu trabekularne kosti, nutritivni status te procijeniti rizik od pothranjenosti u postmenopauzalnih žena s osteoporozom (OP) i osteopenijom (OP-a).
Ispitanici i postupci: Istraživanje uključuje ukupno 60 ispitanica, od kojih je 30 s dijagnosticiranom osteoporozom te 30 s osteopenijom. Glavni kriteriji uključenja u istraživanje bili su ženski spol i nastup menopauze, te ispunjeni neki od SZO kriterija za osteoporozu ili osteopeniju. Također im je uzeta medicinska anamneza uz antropometrijska i denzitometrijska mjerenja, te su ispunile MNA (engl. Mini Nutritional Assessment) upitnik kako bi se procijenio rizik od pothranjenosti.
Rezultati: Pacijentice s osteopenijom su imale više vrijednosti TBS indeksa u odnosu na OP skupinu, ali bez statističke značajnosti (1,25 ± 0,08 vs. 1,29 ± 0,09; P=0,088). Međutim, ispitanice s iskustvom patološkog prijeloma imaju nižu TBS vrijednost u odnosu na ispitanice bez iskustva patološkog prijeloma u anamnezi (1,24 ± 0,08 vs. 1,28 ± 0,08; P=0,051). Nadalje, ispitanice s osteoporozom su imale značajno manji zbroj bodova na MNA upitniku u odnosu na ispitanice s osteopenijom (11,5 (11,0-13,0) vs. 13,0 (12,0-14,0); P=0,011), te su također imale značajno veći udio onih s rizikom za pothranjenost u odnosu na ispitanice s osteopenijom (50 vs. 13,3 %; P=0,002). Značajna pozitivna korelacija dokazana je između zbroja bodova MNA upitnika s ITM (r=0,529; P<0,001), opsegom struka (r=0,534; p<0,001), opsegom bokova (r=0,518; P<0,001), lumbalnim (L1-L4) BMD-om (r=0,299; P=0,021) te BMD-om ukupnog područja kuka (r=0,497; P<0,001). Također, uspoređujući ispitanice s rizikom za pothranjenost i on s normalnim nutritivnim statusom, nije bilo značajne razlike u vrijednostima TBS indeksa (1,25 ± 0,07 vs. 1,28 ± 0,09; P=0,257).
Zaključci: Ovo istraživanje je pokazalo da su ispitanice s osteoporozom su imale značajno veći udio onih s rizikom za pothranjenost u odnosu na ispitanice s osteopenijom, te da je bolji nutritivni status povezan s višim BMD vrijednostima. Daljnje studije su potrebne za dodatnim istraživanjem povezanosti nutritivnog statusa i trabekularne strukture kosti. |
| Abstract (english) | Objectives: Aim of this study was to examine trabecular bone structure, nutritive status and to estimate risk of malnutrition between patients with osteoporosis and osteopenia
Subjects and methods: This study included 60 patients, 30 of them being with diagnosed osteoporosis and the other 30 with osteopenia. The main criteria in the study was female gender, start of menopause, and SZO criteria for osteoporosis and osteopenia. Patients have given detailed anamnesis with anthropometric and densitometric measurements, and they filled a questionnaire to predict a risk of malnutrition.
Results: Patients with osteopenia had higher TBS values than patients with osteoporosis, but without significant difference (1.25 ± 0.08 vs. 1.29 ± 0.09; P=0.088). However, patients with an experience of fracture in anamnesis had lower TBS values than patients without an experience of fracture (1.24 ± 0.08 vs. 1.28 ± 0.08; P=0.051). Likewise, patients with osteoporosis had significantly lower total MNA score than patients with osteopenia (11.5 (11.0-13.0) vs. 13.0 (12.0-14.0); P=0.011). Furthermore, patients with osteoporosis also had significant more participants with a risk of malnutrition compared to the patients with osteopenia (50 vs. 13.3 %; P=0.002). However, there was a significant positive correlation between total MNA score with BMI (r=0.529; P<0.001), waist circumference (r=0.534; p<0.001), hip circumference (r=0.518; P<0.001), lumbar (L1-L4) BMD (r=0.299; P=0.021) and total hip area BMD (r=0.497; P<0.001). Also, comparing the patients with risk of malnutrition with the patients with normal nutritional status, there was not a significant difference in TBS values (1.25 ± 0.07 vs. 1.28 ± 0.09; P=0.257).
Conclusions: This study showed that patients with osteoporosis had significantly more participants with a risk of malnutrition than patients with osteopenia, and that nutritional status was associated with higher BMD values. Further studies are needed to investigate association between nutritional status and trabecular bone structure. |
