Aim of the study: The aim of the study was to assess the risk of bleeding with CRUSADE score in patients with acute non ST elevation myocardial infarction (NSTEMI). Materials and methods: A total of 40 subjects diagnosed with NSTEMI, who were hospitalized at the University Hospital of Split, participated in the study. The survey was conducted from February 1, 2019, to July 1, 2019, and all respondents signed an informed consent. A blood sample in subjects with NSTE-ACS was collected exclusively at admission. From all patients, we collected general and anthropometric data that included age, sex, body height, body weight, hip circumference, and waist circumference. Blood samples were processed in the Laboratory for Medical Chemistry and Biochemistry of the Medical Faculty in Split, no more than 6 hours after sampling. Results: No statistically significant difference in bleeding risk was found between subjects with multivessel disease and those not suffering from multivessel disease (P = 0.630). Within the entire study population, a statistically significant difference in bleeding risk was found between subjects with diabetes mellitus versus those without diabetes mellitus (P = 0.004). According to the results obtained, subjects suffering from diabetes mellitus have a higher risk of bleeding. Likewise, a statistically significant difference was found in the risk of bleeding in subjects treated with percutaneous coronary intervention (PCI) and in those not treated with PCI (P = 0.004) according to which subjects treated with PCI had a lower risk of bleeding. Conclusion: Equally at risk of bleeding are subjects diagnosed with NSTEMI who have multivessel disease and subjects who do not suffer from multivessel disease. Subjects diagnosed with NSTEMI suffering from diabetes mellitus have a higher risk of bleeding, while subjects with the same diagnosis who underwent PCI have a lower risk of bleeding.