| Abstract | Cilj: Cilj ovoga istraživanja bio je utvrditi razliku u pojavnosti i razini postekstrakcijske boli nakon primjene Apernyl konus tableta u ciljanoj skupini ispitanika u odnosu na kontrolnu skupinu koja nije primila lijek.
Ispitanici i metode: Istraživanje je uključivalo 40 ispitanika u dobi od 18 do 80 godina kojima je bila indicirana ekstrakcija zuba. Ispitanici su nasumično podijeljeni u ispitivanu i kontrolnu grupu, pri čemu je svaku grupu činilo 10 žena i 10 muškaraca. Zahvati ekstrakcije zuba provedeni su prema pravilima struke te je odmah po zahvatu ispitivanoj skupini primijenjen lijek. Potom su ispitanici telefonskim pozivom prvi, treći i sedmi dan od zahvata subjektivno ocjenjivali razinu osjećaja boli numeričkom skalom 0-10, pri čemu je ocjena 0 označavala bezbolnost, a ocjena 10 jaku bol. Zabilježena je i dodatna primjena analgetika prvi, treći i sedmi dan od provedenog zahvata ekstrakcije zuba.
Rezultati: U prva tri dana od provedenog zahvata ekstrakcije zuba nije pronađena statistički značajna razlika u pojavnosti i intenzitetu boli između ispitivane i kontrolne skupine (p=0,32; p=0,08). Sedmi dan od zahvata pronađena je statistički značajna razlika između grupa, pri čemu je manji udio ispitanika iz ispitivane skupine prijavio bezbolnost, u usporedbi s kontrolnom skupinom (p=0,047). Nije dokazana razlika u bolnosti nakon zahvata obzirom na spol ispitanika, međutim pokazala se statistički značajna razlika pojave bolnosti ovisno o čeljusti u muških ispitanika na treći dan od zahvata, pri čemu je 60% ispitanika prijavilo bolnost nakon ekstrakcije u donjoj čeljusti te je 100% ispitanika prijavilo bezbolnost nakon provedenog zahvata u gornjoj čeljusti (p=0,036). Dokazana je značajna razlika u procjeni intenziteta boli između skupina ovisno o dobi ispitanika, pri čemu je najveća učestalost bolnosti zabilježena kod ispitanika srednje dobi. Nadalje, rezultati su pokazali da je ukupno 27,5% svih ispitanika koristilo dodatni ibuprofen te nije pronađena razlika između ispitivane i kontrolne skupine, već je pronađena razlika ovisno o čeljusti u kojoj je proveden zahvat, gdje je veći broj ispitanika koristio dodatni ibuprofen nakon ekstrakcije u donjoj čeljusti (p=0,014). Također, rezultati su pokazali značajnu razliku u upotrebi dodatnog ibuprofena obzirom na starosnu dob ispitanika, pri čemu je najviše ispitanika srednje starosne dobi upotrebljavalo dodatni ibuprofen.
Zaključak: Rezultati istraživanja nisu pokazali klinički značajnu razliku u razini subjektivnog osjećaja postekstrakcijske boli nakon imedijatne primjene Apernyl konus tableta. Također, nije se pokazao značajan utjecaj spola ispitanika na pojavnost i razinu boli. Rezultati istraživanja pokazuju veću incidenciju i intenzitet bolnosti, kao i upotrebu dodatnog ibuprofena kod ispitanika srednje dobi. Dokazana je razlika u razini osjećaja boli kod muških ispitanika ovisno o čeljusti, pri čemu se razina boli pokazala manjom nakon vađenja zuba gornje čeljusti. |
| Abstract (english) | Objective: The objective of this survey was to determine the difference in the incidence and level of post-extraction pain after the administration of Apernyl cones in the treatment group compared to the control group who did not receive the medication.
Subjects and methods: The study included 40 subjects aged 18 to 80 years who were indicated for tooth extraction. Subjects were randomly divided into study and control groups, with each group consisting of 10 women and 10 men. Tooth extraction procedures were performed lege artis and immediately after the procedure, the drug was administered in the study group. Then, on the first, third and seventh day after the procedure, the subjects subjectively assessed the level of pain sensation on a numeric scale of 0-10, with a score of 0 indicating painlessness and a score of 10 indicating severe pain. Additional use of analgesics was noted within seven days of the tooth extraction procedure.
Results: There was no statistically significant difference in the incidence of pain between the treatment and control group within the first three days after the tooth extraction procedure (p=0,32; p=0,08). On the seventh day after the procedure, a statistically significant difference was found between the two groups, whereby a smaller proportion of respondents from the treatment group reported no pain, compared to the control group (p = 0.047). There is no evidence of difference in pain after the procedure when it comes to the sex of respondents. However, on the third day after the procedure there was a statistically significant difference in the incidence of pain depending on the jaw among male respondents. Namely, a total of 60% of respondents reported pain after tooth extraction in the lower jaw; and a total of 100% reported no pain after the procedure performed in the upper jaw (p = 0.036). There was a significant difference in the assessment of pain intensity between groups depending on the age of subjects, with the highest incidence of pain recorded in middle-aged subjects. Furthermore, the results showed that a total of 27.5% of all respondents took additional ibuprofen and no difference was found between the treatment and control groups. However, a difference was found depending on the jaw, whereby a higher number of respondents used additional ibuprofen after tooth extraction in the lower jaw (p = 0.014). Also, the results showed a significant difference in the use of additional ibuprofen regarding the age of subjects, with the most middle-aged subjects using additional ibuprofen.
Conclusion: The results of the survey have not shown a statistically significant difference in the level of subjective sensation of post-extraction pain after an immediate administration of Apernyl cones. In addition, there has been no significant influence of the sex of respondents on the incidence and level of pain. The results of the study show a higher incidence and intensity of pain, as well as the use of additional ibuprofen in middle-aged subjects. The survey has shown a difference in the level of pain sensation reported by male respondents depending on the jaw, with the level of pain being less intense after the tooth extraction in the upper jaw. |
