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doctoral thesis
Procjena neurokognitivnih i motoričkih sposobnosti te kvalitete života u bolesnika s upalnim bolestima crijeva blagog do umjerenog stupnja
Split: University of Split, School of Medicine, 2021. urn:nbn:hr:171:364441
Tadin Hadjina, Ivana
University of Split
School of Medicine
Pathophysiology

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Tadin Hadjina, I. (2021). Procjena neurokognitivnih i motoričkih sposobnosti te kvalitete života u bolesnika s upalnim bolestima crijeva blagog do umjerenog stupnja (Doctoral thesis). Split: University of Split, School of Medicine. Retrieved from https://urn.nsk.hr/urn:nbn:hr:171:364441

Tadin Hadjina, Ivana. "Procjena neurokognitivnih i motoričkih sposobnosti te kvalitete života u bolesnika s upalnim bolestima crijeva blagog do umjerenog stupnja." Doctoral thesis, University of Split, School of Medicine, 2021. https://urn.nsk.hr/urn:nbn:hr:171:364441

Tadin Hadjina, Ivana. "Procjena neurokognitivnih i motoričkih sposobnosti te kvalitete života u bolesnika s upalnim bolestima crijeva blagog do umjerenog stupnja." Doctoral thesis, University of Split, School of Medicine, 2021. https://urn.nsk.hr/urn:nbn:hr:171:364441

Tadin Hadjina, I. (2021). 'Procjena neurokognitivnih i motoričkih sposobnosti te kvalitete života u bolesnika s upalnim bolestima crijeva blagog do umjerenog stupnja', Doctoral thesis, University of Split, School of Medicine, accessed 22 November 2024, https://urn.nsk.hr/urn:nbn:hr:171:364441

Tadin Hadjina I. Procjena neurokognitivnih i motoričkih sposobnosti te kvalitete života u bolesnika s upalnim bolestima crijeva blagog do umjerenog stupnja [Doctoral thesis]. Split: University of Split, School of Medicine; 2021 [cited 2024 November 22] Available at: https://urn.nsk.hr/urn:nbn:hr:171:364441

I. Tadin Hadjina, "Procjena neurokognitivnih i motoričkih sposobnosti te kvalitete života u bolesnika s upalnim bolestima crijeva blagog do umjerenog stupnja", Doctoral thesis, University of Split, School of Medicine, Split, 2021. Available at: https://urn.nsk.hr/urn:nbn:hr:171:364441

Metadata
TitleProcjena neurokognitivnih i motoričkih sposobnosti te kvalitete života u bolesnika s upalnim bolestima crijeva blagog do umjerenog stupnja
Title (english)Assessment of neurocognitive and motor performance and quality of life in patients with mild to moderate inflammatory bowel disease
AuthorIvana Tadin Hadjina
MentorJoško Božić (mentor)
Committee memberMaja Valić (predsjednik povjerenstva)
Committee memberSlavica Kozina (član povjerenstva)
Committee memberVesna Šendula-Jengić (član povjerenstva)
GranterUniversity of Split
School of Medicine
(Pathophysiology)
Split
Defense date and country2021, Croatia
Scientific / art field,
discipline and subdiscipline		BIOMEDICINE AND HEALTHCARE
Clinical Medical Sciences
Internal Medicine
Universal decimal classification
(UDC)		616 - Pathology. Clinical medicine
Abstract
Svrha istraživanja: Patogeneza upalne bolesti crijeva (IBD) obuhvaća paletu patofizioloških procesa s implikacijama na sve organske sustave. Iako studije upućuju na dvosmjernu vezu između patogeneze IBD-a i poremećene funkcije središnjeg živčanog sustava, ne postoji još dovoljno dokaza da bi se utvrdilo jesu li opisani neurološki deficiti posljedica samog IBD-a ili su rezultat smanjene kvalitete života, malnutricije, kronične uporabe lijekova ili nečeg drugog Stoga, cilj ovog istraživanja bio je utvrditi neurokognitivne i motoričke sposobnosti te kvalitetu života u bolesnika s IBD-om. Ispitanici i metode: U ovoj presječnoj studiji, koristeći seriju Complex Reactinometer Drenovac (CRD) testova na uzorku od 60 bolesnika s IBD-om i 60 zdravih kontrola, evaluirali smo sljedeće kognitivne domene: konvergentno razmišljanje (CRD-11), perceptivne sposobnosti (CRD-311) i sofisticirano operativno razmišljanje (CRD-411). Najvažniji analizirani parametri bili su ukupno vrijeme rješavanja testa (TTTS), maksimalni kognitivni potencijal (TMIN), točnost i učinkovitost mentalnih procesa (NER). Kvalitetu života uspoređivali smo koristeći SF-36 upitinik (razlika IBD-a i kontrola) te IBDQ-32 upitinik (razlika između ulceroznog kolitisa (UC) i Crohnove bolesti (CD)). Rezultati: Rezultati upućuju na značajno dulji TTTS i TMIN u skupini bolesnika s IBD-om (P < 0.05), a bez razlike između kontrola i bolesnika s IBD-om u kontekstu NER-a. Navedeni rezultati normirani su na dob, indeks tjelesne mase i trajanje edukacije. U svim dimenzijama kvalitete života između bolesnika s IBD-om imali su značajno lošije rezultate od kontrola osim u dimenziji fizičkog funkcioniranja (P=0.064), dok između bolesnika s CD-om i UC-om nije bio razlike u kvaliteti života (P=0.089). Pojedine kategorije kvalitete života negativno su korelirale s trajanjem bolesti i hs-CRP-om, dok indeks tjelesne mase i fekalni kalprotektin nisu korelirali s kvalitetom života. 88 Zaključci: Zaključno, provedena studija pokazala je značajne deficite u neurokognitivnoj i psihomotornoj funkciji u bolesnika s IBD-om. Iako su dobiveni rezultati neovisni o dobi, trajanju edukacije i ITM-u, daljnja istraživanja potrebna su kako bismo razjasnili značaj ovih nalaza. Osim toga, u skladu s ostatkom literature naša studija upućuje na značajno narušenu kvalitetu života bolenika s IBD-om.
Abstract (english)
Objectives: Pathogenesis of inflammatory bowel disease (IBD) includes a myriad of processes implicated in virtually all organ systems. Although previous studies have proposed that patients with IBD exhibit harmful neuropsychological repercussions, the exact pathophysiological mechanisms that would delineate bidirectional relation between IBD and central nervous system are yet to be determined. Namely, it still remains elusive whether the observed neuropsychological deficits are a consequence of IBD itself or as a result of reduced quality of life, Therefore, we aimed to compare the neurocognitive and psychomotor function and quality of live between patients with IBD and healthy controls. Materials and methods: In this cross-sectional study, 60 IBD patients and 60 age/sex-matched controls were included. Computer-based instrument Complex Reactinometer Drenovac (CRD) was used for assessment of cognitive domains: convergent thinking (CRD-11), perceptive abilities (CRD-311) and sophisticated operative thinking (CRD-411). The most important analyzed parameters were total test solving time (TTTS); minimal time of particular test solving (TMIN) and total number of wrong reactions (NER). Quality of life (QoL) was assessed using SF- 36 (IBD vs. Controls) and IBDQ-32 (ulcerative colitis (UC) vs. Crohn's disease (CD)). Results: Performance in all three cognitive tests showed statistically significantly longer TTTS and TMIN in IBD patients (P < 0.05), while there was no significant difference in NER. The aforementioned findings were adjusted for body mass index, age and duration of education. Apart from physical functioning (P=0.064), patients with IBD had poorer results in all other dimensions of SF-36. There was no difference in QoL between patients with UC and CD (P=0.089). Several categories of QoL negatively correlated with disease duration and hs-CRP, whereas there was no correlation with body mass index and fecal calprotectin. Conclusions: In conclusion, our study has shown impaired neurocognitive and psychomotor function in IBD patients compared to controls, especially in mental processing speed and mental endurance of perceptive abilities, convergent thinking and complex operative thinking. Aside from that, we established that QoL is impaired in patients with IBD.
Keywords
Keywords (english)
Languagecroatian
URN:NBNurn:nbn:hr:171:364441
Study programmeTitle: Biology of Neoplasms
Study programme type: university
Study level: postgraduate
Academic / professional title: doktor/doktorica znanosti, područje biomedicine i zdravstvo (doktor/doktorica znanosti, područje biomedicine i zdravstvo)
Type of resourceText
File originBorn digital
Access conditionsOpen access
Embargo expiration date: 2022-11-26
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Created on2021-12-07 07:59:39