Title Peritonejska dijaliza u Splitsko-dalmatinskoj županiji : 21 godina iskustva Title (english) Peritoneal dialysis in Dalmatian County, Croatia : 21 years of a single-center experience Author Marina Grubić Mentor Josipa Radić (mentor)Committee member Duška Glavaš (predsjednik povjerenstva)Committee member Joško Božić (član povjerenstva)Committee member Marino Vilović (član povjerenstva)Granter University of Split Defense date and country 2022, Croatia Scientific / art field, BIOMEDICINE AND HEALTHCARE Abstract Ciljevi: Cilj ovog istraživanja bilo je opisati ukupno 21 godinu liječenja CAPD u razdoblju od
2000. do 2020. godine na Zavodu za nefrologiju i dijalizu, Klinike za unutarnje bolesti,
Kliničkog bolničkog centra Split. Primarni cilj istraživanje bio je analizirati učestalosti i
osobitosti akutnih epizoda peritonitisa (APE) te istražiti postojanje sezonske varijabilnosti
pojedinih mikrobioloških uzročnika. Sekundarni cilj bio je istražiti primarne i sekundarne
ishode liječenja kontinuiranom ambulatornom peritonejskom dijalizom (CAPD).
Ispitanici i postupci: Prikupljeni su podaci koji se odnose na datum rođenja i početka liječenja
CAPD metodom, APE, prevalenciju šećerne bolesti (ŠB), indeksa tjelesne mase, godinu u kojoj
je otkrivena bubrežna bolest, kao i pojedinosti o metodama nadomještanja bubrežne funkcije.
Primarni ishodi istraživanja uključuju smrt te i dalje žive bolesnike pri završetku istraživanja.
Sekundarni ishodi uključuju daljnje liječenje CAPD metodom, TX i prelazak na liječenje HD.
Rezultati: Analizirani su podaci 123 žene i 129 muškaraca. Ukupno 63 bolesnika imala su ŠB.
Medijan dobi na početku liječenja CAPD metodom bio je 56 godina. Medijan trajanja CAPD
liječenja bio je 24 mjeseca. Na kraju istraživanja je 147 bolesnika još uvijek bilo živo, 26 ih je
prešlo na liječenje HD, 97 je transplantiralo bubreg, a 33 ih je još uvijek liječeno CAPD.
Ukupno je zabilježeno 327 APE. Stopa APE bila je 0,08 epizoda / bolesnik-godini. Najčešći
mikrobiološki uzročnik APE bio je koag. neg. Staphylococcus sp. s učestalošću od 17,74%, a u
17,28% rezultata mikrobioloških testova nije nađen mikrobiološki uzročnik.
Zaključci: Rezultati ovog istraživanja daju informacije o učestalosti APE i njihovim
karakteristikama te kao takvi mogu poslužiti u daljnjem unaprjeđenju rada ovog centra, ali i
kao uzor drugim centrima liječenja. Iako se smanjuje incidencija APE i dalje su potrebna
poboljšanja mjera prevencije kao i dodatne edukacije.
Abstract (english) Objectives: This study aimed to describe 21 years of University Hospital Centers’ experience
in treating continuous ambulatory peritoneal dialysis (CAPD) patients from 2000. to 2020.
Primary aim of this study was to analyze the prevalence and incidence of acute peritonitis
episodes (APE), and special attention was given to the seasonal variability of microbiological
causative agents of each APE. Secondary aim of this study was to investigate primary and
secondary outcomes of CAPD treatment.
Subjects and methods: Collected dana regards the date of birth and start of CAPD treatment,
year of renal disease discovery, APE, the prevalence of diabetes mellitus (ŠB), body mass
index, and details regarding renal replacement therapies. Primary outcomes included death or
still alive patients at the end of the study. Secondary outcomes included remaining on CAPD
treatment, a switch to hemodialysis (HD), and renal transplantation (TX).
Results: In this study, 123 women and 129 men were analyzed. In total 63 patients had DM.
At the start of CAPD, the median age was 56 years. The median duration of CAPD treatment
was 24 months. At the end of the study, 147 patients were still alive of which 26 switched to
HD, 33 were still on CAPD treatment, and 97 went through TX. A total of 327 APE were
recorded. APE rate was 0,08 episodes / patient-year. The most common microbiological
causative agent of APE was koag. neg. Staphylococcus sp. with incidence of 17,74% while in
17,28% of microbiological testing results came back sterile.
Conclusions: The results of this study give information about the prevalence and incidence of
APE and their characteristics which may serve in further improvement of practice in this center,
but also as a model for other renal replacement therapy centers. Even though the incidence of
APE is decreasing, further efforts in prevention measures are still needed as well as additional
education.
Keywords
kontinuirana ambulatorna peritonejska dijaliza
kronična bubrežna bolest
metode nadomještanja bubrežne funkcije
akutni peritonitis
šećerna bolest
Keywords (english)
continous ambulatory peritoneal dialysis
kidney failure
renal replacement therapy
acute peritonitis
diabetes mellitus
Language croatian URN:NBN urn:nbn:hr:171:632003 Study programme Title: Medicine Type of resource Text File origin Born digital Access conditions Open access Terms of use Created on 2022-07-20 07:42:15
