Objectives: The aim of this study is to compare the anthropometric and laboratory findings of COVID-19 patients with and without pulmonary embolism and to analize statistically significant differences to determine which factors contribute to the development of pulmonary embolism. Subjects and methods: We conducted a retrospective cohort study with randomly selected 100 COVID-19 patients in the period of 1.1.-31.12.2021., 50 who developed pulmonary embolism and 50 who did not. T-test was used for examining the differences in the numerical variables, while for the qualitative indicators χ2 test was used. The difference in the prevalence of previous diseases and the type of therapy was examined using the Z-test for independent measurements. Results: Most COVID-19 patients are men (60%) as well as most patients who developed pulmonary embolism (54%). The mean age is by 6 years higher in the test group. Smoking is 2.33 times more common in patients with PE, whilst vaccination is 2.33 times more common in patients without PE. 80% of patients have comorbidities with arterial hypertension being the most common one (62.5%). Anticoagulation and/or antiplatelet therapy is 1.57 times more common in the control group. CRP, leukocytes, D-dimers, platelets, and NT-proBNP have higher values in the test group in regards to the controls. In average 11 days were needed from the beginning of the symptoms to the development of pulmonary embolism with the most common location being the segmental branches (38%). Mechanical ventilation was 1.67 times more commonly used in patients with PE. Also there have been 1.75 times more death cases in patients with PE. Conclusions: Older age presents a risk factor for the development of PE, whilst male gender and the number of comorbidities did not show any statistical significance. Anticoagulation and/or antiplatelet therapy did not show any statistically significant reduction in PE. Patients with PE generally have higher values of D-dimers and leukocytes while CRP was not shown as a statistically significant risk factor. There have been more mechanically ventilated patients in the test group, as well as more deaths but without statistical significance.