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master's thesis
Kronične upalne bolesti crijeva dijagnosticirane u djece i adolescenata liječenih u Klinici za dječje bolesti KBC-a Split u periodu od 2011. do 2021.
Split: University of Split, School of Medicine, 2022. urn:nbn:hr:171:847896
Mihovilović, Marin
University of Split
School of Medicine

Institutional repository: MEFST Repository

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Mihovilović, M. (2022). Kronične upalne bolesti crijeva dijagnosticirane u djece i adolescenata liječenih u Klinici za dječje bolesti KBC-a Split u periodu od 2011. do 2021. (Master's thesis). Split: University of Split, School of Medicine. Retrieved from https://urn.nsk.hr/urn:nbn:hr:171:847896

Mihovilović, Marin. "Kronične upalne bolesti crijeva dijagnosticirane u djece i adolescenata liječenih u Klinici za dječje bolesti KBC-a Split u periodu od 2011. do 2021.." Master's thesis, University of Split, School of Medicine, 2022. https://urn.nsk.hr/urn:nbn:hr:171:847896

Mihovilović, Marin. "Kronične upalne bolesti crijeva dijagnosticirane u djece i adolescenata liječenih u Klinici za dječje bolesti KBC-a Split u periodu od 2011. do 2021.." Master's thesis, University of Split, School of Medicine, 2022. https://urn.nsk.hr/urn:nbn:hr:171:847896

Mihovilović, M. (2022). 'Kronične upalne bolesti crijeva dijagnosticirane u djece i adolescenata liječenih u Klinici za dječje bolesti KBC-a Split u periodu od 2011. do 2021.', Master's thesis, University of Split, School of Medicine, accessed 27 December 2024, https://urn.nsk.hr/urn:nbn:hr:171:847896

Mihovilović M. Kronične upalne bolesti crijeva dijagnosticirane u djece i adolescenata liječenih u Klinici za dječje bolesti KBC-a Split u periodu od 2011. do 2021. [Master's thesis]. Split: University of Split, School of Medicine; 2022 [cited 2024 December 27] Available at: https://urn.nsk.hr/urn:nbn:hr:171:847896

M. Mihovilović, "Kronične upalne bolesti crijeva dijagnosticirane u djece i adolescenata liječenih u Klinici za dječje bolesti KBC-a Split u periodu od 2011. do 2021.", Master's thesis, University of Split, School of Medicine, Split, 2022. Available at: https://urn.nsk.hr/urn:nbn:hr:171:847896

Metadata
TitleKronične upalne bolesti crijeva dijagnosticirane u djece i adolescenata liječenih u Klinici za dječje bolesti KBC-a Split u periodu od 2011. do 2021.
Title (english)Chronic inflammatory bowel diseases diagnosed in children and adolescents treated in the Clinic for children's diseases of University hospital of Split in the period from 2011 to 2021
AuthorMarin Mihovilović
MentorIvana Unić (mentor)
Committee memberBranka Polić (predsjednik povjerenstva)
Committee memberJoško Božić (član povjerenstva)
Committee memberIvana Pavlinac Dodig (član povjerenstva)
GranterUniversity of Split
School of Medicine
Split
Defense date and country2022, Croatia
Scientific / art field,
discipline and subdiscipline		BIOMEDICINE AND HEALTHCARE
Clinical Medical Sciences
Pediatrics
Abstract
Ciljevi: Utvrditi učestalost kroničnih upalnih bolesti crijeva i karakteristike bolesnika s osvrtom na endokrinološke manifestacije bolesti u djece i adolescenata hospitaliziranih u Klinici za dječje bolesti KBC-a Split od 2011. do 2021. Ispitanici i metode: 94 bolesnika s kroničnom upalnom bolesti crijeva u Klinici za dječje bolesti KBC-a Split od 2011. do 2021. Analizirani su podatci iz medicinske dokumentacije: dob, pojavnost općih i gastrointestinalnih simptoma i ekstraintestinalnih manifestacija, pubertetski status, TV, ITM, fekalni kalprotektin, 1,25(OH)2D3 i indeks aktivnosti bolesti. Rezultati: Među bolesnicima je 60 (63,8%) dječaka i 34 (36,2%) djevojčice. Incidencija kroničnih upalnih bolesti crijeva u našem uzorku varira od 0 do 10,6 na 100 000 za Crohnovu bolest, za ulcerozni kolitis od 0 do 7 na 100 000 i za indeterminirani oblik od 0 do 2,3 na 100 000 djece i adolescenata. Veći udio bolesnika (88%) ima TV-SD u području od 0 do 2 SD. Među bolesnicima, 54,3% je u području odstupanja ITM-SD od > -2 SD do 0 SD. Sniženu vrijednost 1,25(OH)2D3 ima 71% bolesnika. Zaključci: Incidencija Crohnove bolesti i ulceroznoga kolitisa u Klinici za dječje bolesti KBC-a Split u periodu od 2011. do 2021. se ne razlikuje od literaturnih podataka za Hrvatsku i Južnu Europu. U naših bolesnika učestalost općih simptoma je manja, a učestalost gastrointestinalnih simptoma ista uspoređujući s literaturnim podatcima. Učestalost niske TV prilikom postavljanja dijagnoze među našim bolesnicima je manja nego u literaturnim podatcima. Manji je postotak bolesnika u našem uzorku koji su pretili u odnosu na literaturne podatke. Stupanje težine bolesti je u negativnoj korelaciji s TV, a u pozitivnoj korelaciji s ITM prilikom postavljanja dijagnoze. Podatci o pubertetskom statusu nisu dovoljno često zabilježeni u medicinskoj dokumentaciji što je nužno za proširenje saznanja o ovim bolestima. Među našim bolesnicima, visok udio ima deficit i/ili insuficijenciju 1,25(OH)2D3. Kalprotektin treba još istraživati u pedijatrijskoj populaciji.
Abstract (english)
Objectives: To determine the frequency of chronic inflammatory bowel diseases and patient characteristics with reference to endocrinological manifestations of the disease in children and adolescents hospitalized in the Children's Disease Clinic of KBC Split from 2011 to 2021. Materials and methods: 94 patients with chronic inflammatory bowel disease in the Children's Disease Clinic of KBC Split from 2011 to 2021. Data from medical records were analyzed: age, incidence of general and gastrointestinal symptoms and extraintestinal manifestations, puberty status, TV, BMI , fecal calprotectin, 1,25(OH)2D3 and disease activity index. Results: Among the patients, 60 (63.8%) were boys and 34 (36.2%) were girls. The incidence of chronic inflammatory bowel diseases in our sample varies from 0 to 10.6 per 100,000 for Crohn's disease, for ulcerative colitis from 0 to 7 per 100,000 and for the indeterminate form from 0 to 2.3 per 100,000 children and adolescents. The majority of patients (88%) have TV-SD in the range of 0 to 2 SD. Among patients, 54.3% are in the range of BMI-SD deviation from > -2 SD to 0 SD. 71% of patients have a reduced value of 1,25(OH)2D3. Conclusions: The incidence of Crohn's disease and ulcerative colitis in the Children's Disease Clinic of KBC Split in the period from 2011 to 2021 does not differ from literature data for Croatia and Southern Europe. In our patients, the frequency of general symptoms is lower, and the frequency of gastrointestinal symptoms is the same, comparing with literature data. The frequency of low TV at the time of diagnosis among our patients is lower than in literature data. There is a smaller percentage of patients in our sample who were obese compared to literature data. The severity of the disease is negatively correlated with TV and positively correlated with BMI at the time of diagnosis. Data on puberty status are not recorded often enough in the medical documentation, which is necessary for expanding knowledge about these diseases. Among our patients, a high proportion has a deficit and/or insufficiency of 1,25(OH)2D3. Calprotectin needs to be further investigated in the pediatric population.
Keywords
Keywords (english)
Languagecroatian
URN:NBNurn:nbn:hr:171:847896
Study programmeTitle: Medicine
Study programme type: university
Study level: integrated undergraduate and graduate
Academic / professional title: doktor/doktorica medicine (doktor/doktorica medicine)
Type of resourceText
File originBorn digital
Access conditionsOpen access
Embargo expiration date: 2022-07-27
Terms of useLicence In copyright icon
Created on2022-07-22 09:27:08