Objectives: To study annual consumption of opioid and non-opioid analgesics in Croatia from a group of drugs M01A, M02A, N02A, N02B according to ATC classification of analgesics, the annual cost of the consumption of these drugs and estimating the adequacy of the consumption of opioids from 2007 to 2012. Material and Methods: Data on consumption of analgesics from 2007 to 2012 was collected by the Croatian Agency for Medicinal Products and Medical Devices. Drugs were classified according to the ATC/DDD classification into four groups: M01A, M02A, NO2A and N02B. The results were statistically analyzed according to groups and present the annual consumption of certain drugs by generic names, their prices and the reversal of drug consumption as well as their prices in the analyzed period. Adequacy of opioid consumption in Croatia was analyzed by using the Seya method. The method defines the needs of each country for strong opioids, depending on the pattern of morbidity. Adequate consumption is defined by the assumption that the per capita consumption of opioids in the top twenty countries is at the appropriate level. The need for opioids (Adequacy of Consumption Measure – ACM) was calculated as the ratio between actual spending and the identified needs. Each country is classified by the results into one of five levels with regard to adequate consumption of opioids. Results: Nine drugs were analyzed in the M01A group, whereas in the group M02A seven drugs were analyzed. The use of medications increased in both groups in the period from 2007 to 2012. The best-selling drugs in this group were diclofenac and ibuprofen. Group N02A showed the continuous increase in consumption. Taking into consideration ten analyzed drugs, more than three-quarters of entire consumption in the analyzed period accounted for tramadol and tramadol in various combinations. Out of all the analgesics, only the drugs from group N02B showed a decrease in consumption in the period from 2007 to 2012. The analysis of financial gain showed a 21.8% increase in sale of analgesics in the monitored period with most of the profit referring to the drugs in N02B group. Conclusions: Consumption of opioid and non-opioid analgesics increased from 2007 to 2012. The group N02B deviates from the trends seen in the other groups and it was the only group which reduced consumption in the monitored period. Along with the increase of consumption, an increase of price of analgesics in the analyzed period was recorded as well. Despite the increase in consumption of analgesics, consumption of opioids in Croatia is still inadequate in comparison with other countries in the world.