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master's thesis
GLUT-9 expression in human term placentas of diet regulated gestational diabetes mellitus pregnancies
Split: University of Split, School of Medicine, 2022. urn:nbn:hr:171:062234
Simicevic, Sana
University of Split
School of Medicine

Institutional repository: MEFST Repository

Cite this document

Simicevic, S. (2022). GLUT-9 expression in human term placentas of diet regulated gestational diabetes mellitus pregnancies (Master's thesis). Split: University of Split, School of Medicine. Retrieved from https://urn.nsk.hr/urn:nbn:hr:171:062234

Simicevic, Sana. "GLUT-9 expression in human term placentas of diet regulated gestational diabetes mellitus pregnancies." Master's thesis, University of Split, School of Medicine, 2022. https://urn.nsk.hr/urn:nbn:hr:171:062234

Simicevic, Sana. "GLUT-9 expression in human term placentas of diet regulated gestational diabetes mellitus pregnancies." Master's thesis, University of Split, School of Medicine, 2022. https://urn.nsk.hr/urn:nbn:hr:171:062234

Simicevic, S. (2022). 'GLUT-9 expression in human term placentas of diet regulated gestational diabetes mellitus pregnancies', Master's thesis, University of Split, School of Medicine, accessed 23 November 2024, https://urn.nsk.hr/urn:nbn:hr:171:062234

Simicevic S. GLUT-9 expression in human term placentas of diet regulated gestational diabetes mellitus pregnancies [Master's thesis]. Split: University of Split, School of Medicine; 2022 [cited 2024 November 23] Available at: https://urn.nsk.hr/urn:nbn:hr:171:062234

S. Simicevic, "GLUT-9 expression in human term placentas of diet regulated gestational diabetes mellitus pregnancies", Master's thesis, University of Split, School of Medicine, Split, 2022. Available at: https://urn.nsk.hr/urn:nbn:hr:171:062234

Metadata
TitleGLUT-9 expression in human term placentas of diet regulated gestational diabetes mellitus pregnancies
Title (croatian)Izražaj GLUT-9 u ljudskim posteljicama kod trudnica sa gestacijskim diabetesom mellitusom reguliranog dijetom
AuthorSana Simicevic
MentorSandra Zekić Tomaš (mentor)
Committee memberIvana Kuzmić-Prusac (predsjednik povjerenstva)
Committee memberMerica Glavina Durdov (član povjerenstva)
Committee memberIvana Pavlinac Dodig (član povjerenstva)
GranterUniversity of Split
School of Medicine
Split
Defense date and country2022-07-25, Croatia
Scientific / art field,
discipline and subdiscipline		BIOMEDICINE AND HEALTHCARE
Clinical Medical Sciences
Gynecology and Obstetrics
Abstract
Objectives: To investigate GLUT-9 immunohistochemical expression in decidual cells (DC), extravillous trophoblast (EVTB), villous trophoblast (VTB) and vasculosyntitial membranes (VSM) in placentas from pregnancies complicated with gestational diabetes mellitus (GDM) and to compare the results with placnetas from normal pregnancies. Secondary outcome was to determine neonatal birth weight and placental weight in both study groups and to compare the results. Materials and methods: The study included 13 placentas from pregnancies complicated with GDM, and 11 placentas from normal pregnancies served as a control group. GLUT-9 immunohistochemical expression was noted separately for DC, VTB, EVTB and VSM in placentas from in studied placentas. Results: There was no statistically significant difference in the GLUT-9 immunohistochemical expression among studied groups in all of the studied placental compartents. Neonatal birth weight and placental weight were higher in GDM group compared to control group, however the finding wasnt statistically significant. Conclusions: The results of our study indicate there is no difference in GLUT-9 immunohistochemial expression between studied groups, which supports the thesis that GLUT-9 isn’t a key player in placental glucose uptake when there’s no need for insulin treatment of GDM.
Abstract (croatian)
Ciljevi: Istražiti imunohistokemijski izražaj GLUT-9 u decidualnim stanicama (DC), ekstraviloznom trofoblastu (EVTB), vilozusnom trofoblastu (VTB) i vaskulosincijskim membranama (VSM) u postiljicama iz trudnoća kompliciranih s gestacijskim dijabetes melitusom (GDM) i usporediti rezultate s placentama iz normalnih trudnoća. Sekundarni ishod bio je određivanje novorođenačke porođajne mase i mase posteljice u obje ispitivane skupine i usporediti rezultate. Materijali i metode: Istraživanjem je ispitano 13 posteljica iz trudnoća kompliciranih GDM, a 11 posteljica iz normalnih trudnoća služilo je kao kontrolna skupina. Imunohistokemijski izražaj GLUT-9 zabilježena je odvojeno za DC, VTB, EVTB i VSM u posteljicama od svih ispitivanih posteljica. Rezultati: Nije bilo statistički značajne razlike u imunohistokemijskom izražaju GLUT-9 među ispitivanim skupinama u svim ispitivanim dijelovima posteljice. Neonatalna porođajna težina i težina posteljice bile su veće u GDM skupini u usporedbi s kontrolnom skupinom, međutim rezultat nije bio statistički značajan. Zaključci: Rezultati naše studije su pokazali da nema razlike u imunohistokemijskom izražaju GLUT-9 između ispitivanih skupina, što podupire tezu da GLUT-9 nije ključni igrač u unosu glukoze u posteljici kada nema potrebe za inzulinskim liječenjem GDM-a.
Keywords
Keywords (croatian)
Languageenglish
URN:NBNurn:nbn:hr:171:062234
Study programmeTitle: Medical Studies in English
Study programme type: university
Study level: integrated undergraduate and graduate
Academic / professional title: doktor/doktorica medicine (doktor/doktorica medicine)
Type of resourceText
File originBorn digital
Access conditionsOpen access
Terms of useLicence In copyright icon
Created on2022-09-02 08:41:48