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master's thesis
The impact of location and amount of lung metastases in primary colorectal and renal cell cancer on prognosis : a retrospective observational study
Split: University of Split, School of Medicine, 2022. urn:nbn:hr:171:960893
Wieloch, Melissa Tanja
University of Split
School of Medicine

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Wieloch, M. T. (2022). The impact of location and amount of lung metastases in primary colorectal and renal cell cancer on prognosis : a retrospective observational study (Master's thesis). Split: University of Split, School of Medicine. Retrieved from https://urn.nsk.hr/urn:nbn:hr:171:960893

Wieloch, Melissa Tanja. "The impact of location and amount of lung metastases in primary colorectal and renal cell cancer on prognosis : a retrospective observational study." Master's thesis, University of Split, School of Medicine, 2022. https://urn.nsk.hr/urn:nbn:hr:171:960893

Wieloch, Melissa Tanja. "The impact of location and amount of lung metastases in primary colorectal and renal cell cancer on prognosis : a retrospective observational study." Master's thesis, University of Split, School of Medicine, 2022. https://urn.nsk.hr/urn:nbn:hr:171:960893

Wieloch, M. T. (2022). 'The impact of location and amount of lung metastases in primary colorectal and renal cell cancer on prognosis : a retrospective observational study', Master's thesis, University of Split, School of Medicine, accessed 12 May 2024, https://urn.nsk.hr/urn:nbn:hr:171:960893

Wieloch MT. The impact of location and amount of lung metastases in primary colorectal and renal cell cancer on prognosis : a retrospective observational study [Master's thesis]. Split: University of Split, School of Medicine; 2022 [cited 2024 May 12] Available at: https://urn.nsk.hr/urn:nbn:hr:171:960893

M. T. Wieloch, "The impact of location and amount of lung metastases in primary colorectal and renal cell cancer on prognosis : a retrospective observational study", Master's thesis, University of Split, School of Medicine, Split, 2022. Available at: https://urn.nsk.hr/urn:nbn:hr:171:960893

Metadata
TitleThe impact of location and amount of lung metastases in primary colorectal and renal cell cancer on prognosis : a retrospective observational study
Title (croatian)Utjecaj lokalizacije i količine plućnih metastaza u primarnom kolorektalnom karcinomu i karcinomu bubrežnih stanica na prognozu : retrospektivna opservacijska studija
AuthorMelissa Tanja Wieloch
MentorJohannes Brachmann (mentor)
Committee memberGeorg Gerhard Grabenbauer (predsjednik povjerenstva)
Committee memberJoško Božić (član povjerenstva)
Committee memberSigrun Renate Merger (član povjerenstva)
GranterUniversity of Split
School of Medicine
Split
Defense date and country2022-07-28, Croatia
Scientific / art field,
discipline and subdiscipline		BIOMEDICINE AND HEALTHCARE
Clinical Medical Sciences
Surgery
Abstract
Objectives: Aim of this study was to figure out whether localization and amount of lung metastases can influence the prognosis of the disease. Materials and methods: In this retrospective observational study all patients with newly diagnosed primary colorectal or renal cell carcinoma and only lung metastases administered to Regiomed clinic association between January 1, 2018 and February 1, 2022 were included. In total 35 patients were classified into groups according to primary type of cancer, amount and localization of lung metastases and presence of thoracic lymph node metastases. Results: Patients with metachronous lung metastases (> 6 months after primary diagnosis of cancer) in colorectal and renal cell carcinoma have a statistically significantly higher median survival than patients with synchronous metastases. There was a statistically significant difference in median survival between patients with unilateral versus bilateral lung metastases in colorectal and renal cell carcinoma. In case of a lack of diffuse metastases (bipulmonal + > 1/lobe) in colorectal and renal cell carcinoma a statistically higher median survival time was observed. In absence of thoracic lymph node metastases in colorectal and renal cell carcinoma a statistically significantly higher median survival time of patients was detected. In renal cell carcinoma a statistically significant difference in median survival time was detected in case of unilateral metastases (but results based on a very low sample size). There was no statistically significant difference in median survival time for patients with colorectal versus renal cell carcinoma in general and lung metastases. No statistically significant difference in median survival time was detected for patients with singular versus multiple lung metastases, patients with additional tumors or metastases during the course of the disease, those with varying distance of residence to the specialized clinic of Coburg, patients of a certain gender (female, male), different smoking habits and those with or without adipositas, multimorbidity and immunosuppression or different treatments (surgery, radio-/chemotherapy or both). Conclusion: Although there might be an association between localization and amount of lung metastases and time of survival, additional research and especially studies with bigger sample sizes are needed for more precise evidence.
Abstract (croatian)
Ciljevi: Cilj ovog istraživanja bio je utvrditi mogu li lokalizacija i količina plućnih metastaza utjecati na prognozu bolesti. Materijali i metode: U ovu retrospektivnu opservacijsku studiju uključeni su svi bolesnici klinike Regiomed kojima je u periodu između 01.01.2018. i 01.02.2022 bio novodijagnosticiran primarni kolorektalni karcinom ili karcinom bubrežnih stanica te su imali samo plućne metastaze. Ukupno 35 bolesnika podijeljeno je u grupe prema vrsti primarnog tumora, količini i lokalizaciji plućnih metastaza i prisutnosti metastaza u torakalnim limfnim čvorovima. Rezultati: Razvoj metakronih metastaza u plućima (> 6 mjeseci nakon primarne dijagnoze tumora) u kolorektalnom karcinomu i karcinomu bubrežnih stanica ima statistički značajno veći medijan preživljavanja u odnosu na prisutnost sinkronih metastaza. Utvrđena je statistički značajna razlika u medijanu preživljavanja kad se uspoređuju unilateralne u odnosu na bilateralne plućne metastaze. U slučaju odsutnosti difuznih metastaza (bipulmonalnih ili više od jedne metastaze u jednom plućnom režnju) u kolorektalnom karcinomu i karcinomu bubrežnih stanica uočen je statistički značajno veći medijan preživljavanja. Utvrđen je statistički značajno veći medijan preživljavanja ukoliko nisu prisutne metastaze u torakalnim limfnim čvorovima. U karcinomu bubrežnih stanica uočena je statistički značajna razlika u medijanu preživljavanja kod jednostranih metastaza (ali rezultati su temeljeni na vrlo malom uzorku). Nije utvrđena statistički značajna razlika u medijanu preživljavanja za kolorektalni karcinom u odnosu na karcinom bubrežnih stanica općenito ili s prisutnim plućnim metastazama. Nije uočena niti statistički značajna razlika u medijanu preživljavanja kod prisutnosti singularnih u odnosu na multiple metastaze, u slučaju razvoja dodatnih tumora ili bolesti za vrijeme trajanja primarnog karcinoma, u slučaju udaljenosti od specijalizirane klinike Coburg, kod muškog ili ženskog spola, kod pušača i adipoznih bolesnika, kod bolesnika s dodatnim komorbiditetima i imunosupresivnih bolesnika, ili kod različitih vrsta liječenja (kirurgija, radioterapija, kemoterapija ili kombinacija radioterapije i kemoterapije). Zaključak: Iako može postojati povezanost između količine i lokalizacije plućnih metastaza i preživljavanja, potrebno je provesti dodatna istraživanja, naročito na većem uzorku bolesnika kako bi rezultati bili precizniji.
Keywords
Keywords (croatian)
Languageenglish
URN:NBNurn:nbn:hr:171:960893
Study programmeTitle: Medical Studies in English
Study programme type: university
Study level: integrated undergraduate and graduate
Academic / professional title: doktor/doktorica medicine (doktor/doktorica medicine)
Type of resourceText
File originBorn digital
Access conditionsOpen access
Terms of useLicence In copyright icon
Created on2022-09-02 09:52:39