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master's thesis
Ovisnost ishoda liječenja o genotipu hepatitisa C
Split: University of Split, School of Medicine, 2013. urn:nbn:hr:171:828163
Vuksan, Ana
University of Split
School of Medicine

Institutional repository: MEFST Repository

Cite this document

Vuksan, A. (2013). Ovisnost ishoda liječenja o genotipu hepatitisa C (Master's thesis). Split: University of Split, School of Medicine. Retrieved from https://urn.nsk.hr/urn:nbn:hr:171:828163

Vuksan, Ana. "Ovisnost ishoda liječenja o genotipu hepatitisa C." Master's thesis, University of Split, School of Medicine, 2013. https://urn.nsk.hr/urn:nbn:hr:171:828163

Vuksan, Ana. "Ovisnost ishoda liječenja o genotipu hepatitisa C." Master's thesis, University of Split, School of Medicine, 2013. https://urn.nsk.hr/urn:nbn:hr:171:828163

Vuksan, A. (2013). 'Ovisnost ishoda liječenja o genotipu hepatitisa C', Master's thesis, University of Split, School of Medicine, accessed 26 December 2024, https://urn.nsk.hr/urn:nbn:hr:171:828163

Vuksan A. Ovisnost ishoda liječenja o genotipu hepatitisa C [Master's thesis]. Split: University of Split, School of Medicine; 2013 [cited 2024 December 26] Available at: https://urn.nsk.hr/urn:nbn:hr:171:828163

A. Vuksan, "Ovisnost ishoda liječenja o genotipu hepatitisa C", Master's thesis, University of Split, School of Medicine, Split, 2013. Available at: https://urn.nsk.hr/urn:nbn:hr:171:828163

Metadata
TitleOvisnost ishoda liječenja o genotipu hepatitisa C
AuthorAna Vuksan
MentorIrena Drmić Hofman (mentor)
GranterUniversity of Split
School of Medicine
Split
Defense date and country2013, Croatia
Scientific / art field,
discipline and subdiscipline		BIOMEDICINE AND HEALTHCARE
Clinical Medical Sciences
Infectology
Abstract
Ovom studijom željeli smo empirijski i klinički provjeriti dosadašnje znanstvene pretpostavke da je genotip I hepatitisa C potencijalno najrezistentniji genotip hepatitisa C. U desetgodišnjem razdoblju od 2. siječnja 2004. do 3. srpnja 2013. proveli smo studiju koja je uključila 250 bolesnika koji su zbog hepatitisa C liječeni na Klinici za infektologiju Kliničkog bolničkog centra Split. Molekularna analiza genotipova provedena je u Laboratoriju za kliničku genetiku Zavoda za patologiju, sudsku medicinu i citologiju KBC Split. U retrospektivnoj analizi distribucije HCV genotipova u 250 bolesnika s kroničnim hepatitisom C sa šireg područja Splita pokazala je da je većina infekcija prouzrokovana genotipovima I i III (50,8% i 44,8%). Infekcije genotipovima II i IV epidemiološki zauzimaju manje od 5% ukupne ispitane populacije, dok genotip VI nije utvrđen ni u jednog bolesnika. Analiza povezanosti rizičnih faktora za infekciju i genotipova virusa hepatitisa C pokazala je povezanost infekcije hepatitisom C (genotipovi I i III) u bolesnika koji su koristili intravenski droge (tip I – 20,0%, tip III – 50,0%, tip IIIa – 100,0%), te u onih bolesnika koji su nekoć bili podvrgnuti transfuzijama (tip I – 20,0%, tip III - 16,7%). Terapijski najrezistentniji tip hepatitisa C je genotip I/Ia/Ib, te je za njegovu remisiju potrebno najdulje prosječno vrijeme liječenja (9.8 mjeseci). Prosječno trajanje liječenja (do remisije) je kod tipa I/Ia/Ib minimalno 3 mjeseca duže negoli kod ostalih genotipova, čime je potvrđena osnovna hopiteza.
Abstract (english)
The aim of this restrospective study was prove empirically and clinicaly that hepatitis C genotype I is potentially the most difficult to treat. Study included 250 patients who were treated due hepatitis C at the Clinic for Infectious Diseases, University Hospital Split, in 10-years period, from January 2004 to July 2013. Molecular analysis of genotypes was carried out in the Laboratory of Clinical Genetics, Department of Pathology, Forensic Medicine and Cytology, University Hospital Split. In the retrospective analysis of the distribution of HCV genotypes in 250 patients with chronic hepatitis C has shown that the most prevalent genotypes were I and III (50.8% and 44.8%, respectively). Genotypes II and IV comprised only 5% of the total number, while genotype VI was not detected. Analysis of the association between risk factors and HCV genotypes showed the most common association between hepatitis C infection (genotypes I and III) and intravenous drugs abuse (type I – 20 %, type III – 50 %, type IIIa – 100 %), and previous blood transfusions (type I – 20 %, type III – 16,7 %). The most refractory genotype I with subtypes Ia and Ib had longer treatment duration (average 9.8 months), at least 3 months longer than for other genotypes, which confirms basic hypothesis.
Keywords
Keywords (english)
Languagecroatian
URN:NBNurn:nbn:hr:171:828163
Study programmeTitle: Medicine
Study programme type: university
Study level: integrated undergraduate and graduate
Academic / professional title: doktor/doktorica medicine (doktor/doktorica medicine)
Type of resourceText
File originBorn digital
Access conditionsAccess restricted to students and staff of home institution
Terms of useLicence In copyright icon
Created on2016-04-28 12:26:07