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doctoral thesis
Korelacija intratumorske i peritumorske ekspresije endoglina (CD 105) i kliničkopatoloških faktora u bolesnika operiranih zbog rektalnog karcinoma
Split: University of Split, School of Medicine, 2016. urn:nbn:hr:171:711157
Martinović, Željko
University of Split
School of Medicine

Institutional repository: MEFST Repository

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Martinović, Ž. (2016). Korelacija intratumorske i peritumorske ekspresije endoglina (CD 105) i kliničkopatoloških faktora u bolesnika operiranih zbog rektalnog karcinoma (Doctoral thesis). Split: University of Split, School of Medicine. Retrieved from https://urn.nsk.hr/urn:nbn:hr:171:711157

Martinović, Željko. "Korelacija intratumorske i peritumorske ekspresije endoglina (CD 105) i kliničkopatoloških faktora u bolesnika operiranih zbog rektalnog karcinoma." Doctoral thesis, University of Split, School of Medicine, 2016. https://urn.nsk.hr/urn:nbn:hr:171:711157

Martinović, Željko. "Korelacija intratumorske i peritumorske ekspresije endoglina (CD 105) i kliničkopatoloških faktora u bolesnika operiranih zbog rektalnog karcinoma." Doctoral thesis, University of Split, School of Medicine, 2016. https://urn.nsk.hr/urn:nbn:hr:171:711157

Martinović, Ž. (2016). 'Korelacija intratumorske i peritumorske ekspresije endoglina (CD 105) i kliničkopatoloških faktora u bolesnika operiranih zbog rektalnog karcinoma', Doctoral thesis, University of Split, School of Medicine, accessed 26 November 2024, https://urn.nsk.hr/urn:nbn:hr:171:711157

Martinović Ž. Korelacija intratumorske i peritumorske ekspresije endoglina (CD 105) i kliničkopatoloških faktora u bolesnika operiranih zbog rektalnog karcinoma [Doctoral thesis]. Split: University of Split, School of Medicine; 2016 [cited 2024 November 26] Available at: https://urn.nsk.hr/urn:nbn:hr:171:711157

Ž. Martinović, "Korelacija intratumorske i peritumorske ekspresije endoglina (CD 105) i kliničkopatoloških faktora u bolesnika operiranih zbog rektalnog karcinoma", Doctoral thesis, University of Split, School of Medicine, Split, 2016. Available at: https://urn.nsk.hr/urn:nbn:hr:171:711157

Metadata
TitleKorelacija intratumorske i peritumorske ekspresije endoglina (CD 105) i kliničkopatoloških faktora u bolesnika operiranih zbog rektalnog karcinoma
Title (english)Correlation of intratumoral and peritumoral expression of endoglin (CD105) and clinicopathological factors in patients undergoing surgery for rectal carcinoma
AuthorŽeljko Martinović
VIAF: 305601578
MentorDražen Kovač (mentor)
Committee memberSnježana Tomić (predsjednik povjerenstva)
Committee memberNikica Družijanić (član povjerenstva)
Committee memberNives Jonjić (član povjerenstva)
GranterUniversity of Split
School of Medicine
Split
Defense date and country2016, Croatia
Scientific / art field,
discipline and subdiscipline		BIOMEDICINE AND HEALTHCARE
Clinical Medical Sciences
Pathology
Universal decimal classification
(UDC)		616 - Pathology. Clinical medicine
Abstract
Uvod: Uloga endoglina i prognostičko značenje angiogeneze u Dukes B karcinomu rektuma još uvijek su nedovoljno neistraženi. Hipoteza i ciljevi: Ekspresija endoglina i mikrovaskularna gustoća su prognostički čimbenici rizika kod bolesnika s Dukes B karcinomom rektuma. Cilj ovog istraživanja je ispitati ekspresiju endoglina (CD105) u reseciranim uzorcima karcinoma rektuma i odnos između mikrovaskularne gustoće (MVD), kliničkopatoloških čimbenika, preživljenja bolesnika i recidiva tumora. Materijali i metode: U istraživanje je uključeno 95 uzoraka primarnog adenokarcinoma rektuma, 67 uzoraka korespondentne susjedne normalne sluznice i 73 uzorka udaljene normalne sluznice uzetih od kirurškog preparata reseciranog tumora rektuma. Uzorci su uklopljeni u parafin i imunohistokemijski obojeni na CD105 endotelni antigen te je provedeno brojanje malih krvnih žila. Za točno mjerenje CD105-MVD korišten je računalno objedinjeni sustav Alphelys Spot Browser 2. Rezultati: CD105-MVD u tumoru bila je značajno veća u usporedbi s korespondentnom susjednom sluznicom (P<0,0001) i udaljenom normalnom sluznicom (P<0,0001). Nije bilo statistički značajne razlike u CD105-MVD s obzirom na starosnu dob, spol, lokaciju tumora, stupanj diferencijacije, histološki tip tumora, dubinu invazije i veličinu tumora. Ukupna stopa preživljenja bolesnika bila je značajno veća u grupi bolesnika s manjom CD105-MVD u odnosu na skupinu s većom CD105- MVD (log rank test, P=0,0406). Učestalost recidiva tumora bila je značajno veća u podskupini bolesnika s manjim vrijednostima MVD tumora od izračunate granične vrijednosti od bolesnika s većim vrijednostima od granične vrijednosti MVD tumora. Zaključak: Niska ekspresija CD105 i niska CD105-MVD su prognostički čimbenici lošeg preživljenja bolesnika i povećanog rizika za recidiv tumora u skupini bolesnika s Dukes B karcinomom rektuma.
Abstract (english)
Background: The role endoglin in the Dukes B rectal cancer still unexplored. The aim of this study was to examine the expression of endoglin (CD105) in resected rectal cancer and evaluate the relationship between microvessels density (MVD), clinicopathological factors and survival. Hypothesis and Objectives: Endoglin expression and microvessel density are prognostic risk factors in patients with Dukes B rectal cancer. The aim of this study was to determine the endoglin expression in resected specimens of rectal cancer and the relationship between microvessel density (MVD), clinical and pathological factors, patients survival and tumor recurrence. Materials and Method: The study included 95 primary rectal adenocarcinomas, corresponding 67 adjacent and 73 distant normal mucosa specimens from surgical resection samples. Tumor specimens were paraffin-embedded and immunohistochemical staining for the CD105 endothelial antigen was performed to count CD105-MVD. For exact measurement of the CD105-MVD used a computer-integrated system Alphelys Spot Browser 2. Results: The intratumoral CD105-MVD was significantly higher compared with corresponding adjacent mucosa (P<0.0001) and distant mucosa specimens (P<0.0001). There was no significant difference in the CD105-MVD according to patients age, gender, tumor location, grade of differentiation, hystological type, depth of tumor invasion and tumor size. The overall survival rate was significantly higher in the low CD105-MVD group of patients than the high CD105-MVD group of patients (log rank test, P=0.0406). Conclusions: The lower expression of CD105 and lower CD105-MVD are factors to predict the possibility of poor survival of Dukes B rectal carcinoma.
Keywords
Keywords (english)
Languagecroatian
URN:NBNurn:nbn:hr:171:711157
Study programmeTitle: Obtaining a doctorate of science outside of doctoral studies
Study programme type: university
Study level: postgraduate
Academic / professional title: doktor/doktorica znanosti (doktor/doktorica znanosti)
Type of resourceText
File originBorn digital
Access conditionsOpen access
Terms of useLicence In copyright icon
Created on2023-05-15 08:24:55