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doctoral thesis
Utjecaj infekcije humanim papiloma virusom i izražajnosti epidermalnog čimbenika rasta (EGF-a) na pločasti karcinom grkljana
Split: University of Split, School of Medicine, 2015. urn:nbn:hr:171:479508
Kontić, Mirko
University of Split
School of Medicine

Institutional repository: MEFST Repository

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Kontić, M. (2015). Utjecaj infekcije humanim papiloma virusom i izražajnosti epidermalnog čimbenika rasta (EGF-a) na pločasti karcinom grkljana (Doctoral thesis). Split: University of Split, School of Medicine. Retrieved from https://urn.nsk.hr/urn:nbn:hr:171:479508

Kontić, Mirko. "Utjecaj infekcije humanim papiloma virusom i izražajnosti epidermalnog čimbenika rasta (EGF-a) na pločasti karcinom grkljana." Doctoral thesis, University of Split, School of Medicine, 2015. https://urn.nsk.hr/urn:nbn:hr:171:479508

Kontić, Mirko. "Utjecaj infekcije humanim papiloma virusom i izražajnosti epidermalnog čimbenika rasta (EGF-a) na pločasti karcinom grkljana." Doctoral thesis, University of Split, School of Medicine, 2015. https://urn.nsk.hr/urn:nbn:hr:171:479508

Kontić, M. (2015). 'Utjecaj infekcije humanim papiloma virusom i izražajnosti epidermalnog čimbenika rasta (EGF-a) na pločasti karcinom grkljana', Doctoral thesis, University of Split, School of Medicine, accessed 27 December 2024, https://urn.nsk.hr/urn:nbn:hr:171:479508

Kontić M. Utjecaj infekcije humanim papiloma virusom i izražajnosti epidermalnog čimbenika rasta (EGF-a) na pločasti karcinom grkljana [Doctoral thesis]. Split: University of Split, School of Medicine; 2015 [cited 2024 December 27] Available at: https://urn.nsk.hr/urn:nbn:hr:171:479508

M. Kontić, "Utjecaj infekcije humanim papiloma virusom i izražajnosti epidermalnog čimbenika rasta (EGF-a) na pločasti karcinom grkljana", Doctoral thesis, University of Split, School of Medicine, Split, 2015. Available at: https://urn.nsk.hr/urn:nbn:hr:171:479508

Metadata
TitleUtjecaj infekcije humanim papiloma virusom i izražajnosti epidermalnog čimbenika rasta (EGF-a) na pločasti karcinom grkljana
AuthorMirko Kontić
MentorValdi Pešutić-Pisac (mentor)
Committee memberGoran Račić (predsjednik povjerenstva)
Committee memberSnježana Tomić (član povjerenstva)
Committee memberIvana Goić Barišić (član povjerenstva)
GranterUniversity of Split
School of Medicine
Split
Defense date and country2015, Croatia
Scientific / art field,
discipline and subdiscipline		BIOMEDICINE AND HEALTHCARE
Clinical Medical Sciences
Universal decimal classification
(UDC)		616 - Pathology. Clinical medicine
Abstract
Cilj ovoga rada bio je utvrditi prisutnost infekcije humanim papiloma virusom (HPV) i izražajnost receptora epidermalnog čimbenika rasta (EGFR) te njihove moguće povezanosti s histopatološkim i kliničkim značajkama pločastog karcinoma grkljana. Isto tako trebalo je ispitati utjecaj EGFR-a u pacijenata s HPV pozitivnim pločastim karcinomom grkljana na prognozu i preživljenje bolesnika. U istraživanje je bilo uključeno 196 bolesnika s pločastim karcinomom grkljana liječenih u Klinici za bolesti uha, grla i nosa i kirurgiju glave i vrata KBC-a Split u razdoblju od 1. siječnja 2000. do 31. prosinca 2009. godine. Uočili smo povezanost HPV infekcije s patohistološkim gradusom, sklonošću regionalnom metastaziranju, stadijem i recidivom bolesti te statusom i preživljenjem bolesnika, ali bez statističke značajnosti. Dokazana je statistički značajna povezanost stupnja izražajnosti EGFR-a (p < 0,001) i patohistološkoga gradusa, stadija bolesti, sklonosti metastaziranju, povrata (recidiva) bolesti, statusa i preživljenja bolesnika. Kaplan-Meierova krivulja preživljenja za bolesnike s HPV pozitivnim karcinomima koja nije statistički značajna (Log Rank test, χ2 = 1,705; df = 1; p = 0,192), pokazala je bitno bolje preživljenje kod bolesnika koji su bili pozitivni na visokorizične sojeve HPV-a. Statistički značajna razlika preživljenja dokazana je između četiri skupine bolesnika koje imaju različit stupanj izražajnosti EGFR-a (Log Rank test; χ2 = 75.049; df = 3; p < 0,001). Također je statistički značajna povezanost (χ2 = 9,490; df = 3; p = 0,023) infekcije HPV-om i izražajnosti EGFR-a. U studiji nije dokazana statistički značajna povezanost kategorija bolesnika različitih odnosa izražajnosti HPV-a i EGFR-a sa stadijem bolesti, patohistološkim gradusom, sklonošću metastaziranju i preživljenjem, ali je u opisanim kategorijama dokazana statistička značajnost prema sklonosti recidivu bolesti (χ2 = 13,129; df = 3; p = 0,004). Krivulja preživljenja navedenih kategorija bolesnika različitog odnosa izražajnosti HPV-a i EGFR-a pokazala je statistički značajnu razliku (Log Rank test, χ2 = 12,178; df = 3; p = 0,007) preživljenja s izrazito slabijim preživljenjem u obje kategorije ispitanika kojima je dokazana pojačana izražajnost EGFR-a. Time se EGFR potvrđuje kao dominantna komponenta za određivanje prognoze, odnosno mogućeg preživljenja bolesnika s pločastim karcinomom grkljana.
Abstract (english)
The aim of this study was to determine the presence of human papilloma virus (HPV) infection and expression of epidermal growth factor receptor (EGFR) and their possible association with clinical and histopathologic features of laryngeal squamous cell carcinoma. The impact of EGFR expression in patients with HPV - positive squamous cell larynx carcinoma on prognosis and survival, was also examined. The study included 196 patients with squamous cell larynx carcinoma, treated in the Department for Ear, Nose and Throat and Head and Neck Surgery, University Hospital Split, Croatia in period from January 1, 2000. to December 31, 2009. No statistical significance demonstrated correlation of HPV infection with histological grade, tendency for regional metastasis, recurrence of disease, stage, status and survival of patients. However, statistically significant correlation was demonstrated between the level of EGFR expression (p<0.001) according to histopathological grade, stage of disease, tendency to metastasize, return (recurrence) of disease, status and survival of patients. Kaplan-Meier survival curves for patients with HPV - positive cancers, which was not statistically significant (Log Rank test, χ2=1.705; df=1; p=0.192) demonstrated significantly better survival in patients who were positive for high risk HPV strains. Statistically significant survival difference was demonstrated between the four groups of patients with different degree of EGFR expression (Log Rank test, χ2=75,049; df=3; p<0.001). Statistically significant association was also demonstrated between (χ2=9.490; df=3; p=0.023) HPV infection and EGFR expression. No statistically significant correlation was found between different patient categories in relation to HPV and EGFR expression to the stage of disease, histological grade, tendecy to metastasize and survival; within categories statistically significant tendency toward recurrence was found (χ2=13.129; df=3; p=0.004). Survival curves for categories with different expression of HPV and EGFR showed a statistically significant difference in survival (Log Rank test, χ2=12.178; df=3; p=0.007), with markedly poor survival in both categories who demonstrated enhanced expression of EGFR. This confirms the EGFR as a dominant component for determining prognosis, and possible survival.
Keywords
Keywords (english)
Languagecroatian
URN:NBNurn:nbn:hr:171:479508
Study programmeTitle: Basic and clinical medical sciences
Study programme type: university
Study level: postgraduate
Academic / professional title: doktor/doktorica znanosti, područje biomedicine i zdravstva, polje kliničke medicinske znanosti (doktor/doktorica znanosti, područje biomedicine i zdravstva, polje kliničke medicinske znanosti)
Type of resourceText
File originBorn digital
Access conditionsOpen access
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Created on2023-05-19 13:07:50