Objectives: The aim of this research was to determine the attitudes and knowledge of general practitioners about the importance of proper use of inhalation therapy in patients with COPD. Materials and methods: A cross-sectional study was conducted using an online survey questionnaire in which general practitioners from the Split-Dalmatia County participated. In the period 13 - 28 June 2023 an invitation to participate in the research was sent to the official e-mail addresses of all family doctors and family medicine specialists in the Split-Dalmatia County. The first part of the questionnaire contained seven questions about demographic data and data related to work in a family medicine practice, and the second part of the questionnaire contained 17 questions about the knowledge and attitudes of respondents about diagnosing and treating patients with COPD and about the importance of applying the correct inhalation technique in COPD patients. Results: A total of 100 respondents participated in the research, of which 41% medical doctors and 59% specialists and residents of family medicine. Forty three percent of respondents knew the current GOLD guidelines for recognition, diagnosis and treatment of COPD patients well or very well. A spirometer in the doctor's office had 39% of respondents, and 42% of them were considered capable of interpreting spirometry results. Although the majority (91%) agreed with the statement that the improper use of inhalation therapy is one of the most important reasons for the poor regulation of the disease, only half of the respondents instruct the patient to return with the prescribed medication. Conclusions: Although general practitioners know the importance of applying the correct technique of inhalation therapy and its influence on the regularity of patients suffering from COPD, they do not have the necessary knowledge about the differences between the available types of inhalers and they do not sufficiently educate patients about the correct technique of using inhaled drugs.