Title Procjena rizika za sarkopeniju u osoba oboljelih od posttraumatskog stresnog poremećaja Title (english) Risk assessment for sarcopenia in individuals with posttraumatic stress disorder Author Ana Vidović Mentor Tina Tičinović Kurir (mentor)Committee member Davor Lasić (predsjednik povjerenstva)Committee member Joško Božić (član povjerenstva)Committee member Marino Vilović (član povjerenstva)Granter University of Split Defense date and country 2023-07-14, Croatia Scientific / art field, BIOMEDICINE AND HEALTHCARE Abstract Cilj istraživanja: Glavni cilj istraživanja bio je procijeniti rizik za sarkopeniju kod osoba
oboljelih od PTSP-a. Dodatni cilj bio je procijeniti učestalost simptoma manjka testosterona u
osoba oboljelih od PTSP-a i ispitati povezanost rizika za sarkopeniju sa simptomima manjka
testosterona.
Ispitanici i postupci: U ovu presječnu studiju uključeno je 60 veterana Domovinskog rata koji
boluju od PTSP-a i liječe se u Centru za psihotraumu, Klinike za psihijatriju Kliničkog
bolničkog centra u Splitu. Svim ispitanicima su prikupljeni anamnestički podaci, obavljena su
antropometrijska mjerenja i mjerenja sastava tijela, te je uzet uzorak venske krvi za
laboratorijsku analizu. Ispitanici su ispunili SARC-F upitnik za procjenu rizika za sarkopeniju
i AMS upitnik za procjenu simptoma manjka testosterona.
Rezultati: U ispitivanoj populaciji čak 50 % bolesnika s PTSP-om imalo je povećan rizik za
sarkopeniju. Utvrđena je statistički značajna negativna povezanost u ispitivanoj populaciji
između rizika za sarkopeniju i vrijednosti C-reaktivnog proteina (P = 0,049). Nije utvrđena
statistički značajna povezanost između rizika za sarkopeniju i postotka mišićne mase (P =
0,049), postotka masnog tkiva (P = 0,248) te indeksa tjelesne mase (P = 0,370). Bolesnici
boljega socioekonomskog statusa (prosječnoga i iznadprosječnoga) nisu imali značajno niži
rizik za sarkopeniju u odnosu na bolesnike ispodprosječnoga socioekonomskog statusa (P =
0.086). Bolesnici bez završene srednje škole imali su značajno veći rizik za sarkopeniju u
odnosu na bolesnike sa srednjom i višom ili visokom stručnom spremom (P = 0.043). Od
ukupne populacije, samo 5 % bolesnika nije imalo simptome povezane s manjkom testosterona,
dok je čak 73 % bolesnika imalo teške simptome povezane s manjkom testosterona. Bolesnici
s teškim simptomima povezanim s manjkom testosterona imali su značajno veći rizik za
sarkopeniju u odnosu na bolesnike s blažim simptomima ili one bez simptoma (P = 0,008).
Duljina trajanja bolesti i vrijeme provedeno u ratu nisu bili značajno povezani sa simptomima
manjka testosterona procijenjenim AMS upitnikom (P = 0.632).
Zaključci: Ovo istraživanje pokazalo je visoku prevalenciju povećanog rizika za sarkopeniju
i teških simptoma povezanih s manjkom testosterona u osoba oboljelih od PTSP-a. Oboljeli od
PTSP-a koji su nižeg stupnja obrazovanja imaju značajno veći rizik za sarkopeniju. Značajno
veći rizik za sarkopeniju imaju i oboljeli od PTSP-a koji maju teške simptome manjka
testosterona.
Abstract (english) Objectives: The main objective of this research was to assess the risk of sarcopenia in
individuals with PTSD. An additional objective was to evaluate the frequency of testosterone
deficiency symptoms in individuals with PTSD and examine the association between the risk
of sarcopenia and symptoms of testosterone deficiency.
Subjects and Procedures: In this cross-sectional study, 60 veterans who suffer from PTSD
and receive treatment at the Psychotrauma Center, Department of Psychiatry, University
Hospital of Split, were included. Anamnestic data were collected from all participants,
anthropometric measurements and body composition measurements were performed, and blood
sample was taken for laboratory analysis. The participants completed the SARC-F
questionnaire to assess the risk of sarcopenia and the AMS questionnaire to assess symptoms
of testosterone deficiency.
Results: In the examined population, 50% of patients with PTSD had an increased risk for
sarcopenia. A statistically significant negative correlation was found in the examined
population between the risk for sarcopenia and the levels of C-reactive protein (P = 0.049). No
statistically significant associations were found between the risk for sarcopenia and the
percentage of muscle mass (P = 0.049), percentage of body fat (P = 0.248), and body mass
index (P = 0.370). Patients with a higher socioeconomic status (average and above-average)
did not have significantly lower risk for sarcopenia compared to patients with below-average
socioeconomic status (P = 0.086). Patients without a completed high school education had a
significantly higher risk for sarcopenia compared to patients with a high school diploma, higher
education, or a professional degree (P = 0.043). Of the total population, only 5% of patients did
not have symptoms related to testosterone deficiency, while as many as 73% of patients had
severe symptoms associated with testosterone deficiency. Patients with severe symptoms
related to testosterone deficiency had a significantly higher risk for sarcopenia compared to
patients with milder symptoms or those without symptoms (P = 0.008). The duration of the
illness and the time spent in the war were not significantly associated with symptoms of
testosterone deficiency assessed by the AMS questionnaire (P = 0.632).
Conclusions: Individuals with PTSD, have high prevalence of increased risk for sarcopenia
and severe symptoms associated with testosterone deficiency. Patients with lower levels of
education and PTSD have a significantly higher risk for sarcopenia. Additionally, patients with
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PTSD who experience severe symptoms of testosterone deficiency have a significantly higher
risk for sarcopenia.
Keywords
Posttraumatski stresni poremećaj
sarkopenija
Keywords (english)
Posttraumatic stress disorder
sarcopenia
Language croatian URN:NBN urn:nbn:hr:171:042195 Study programme Title: Medicine Type of resource Text File origin Born digital Access conditions Open access Terms of use Created on 2023-07-13 11:35:32
