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master's thesis
A retroperspective pre-post analysis of changes in the heart rate variability parameters in chronic pain patients performing a 4-week multimodal pain therapy
Split: University of Split, School of Medicine, 2023. urn:nbn:hr:171:531537
Brüderlin, Jakob
University of Split
School of Medicine

Institutional repository: MEFST Repository

Cite this document

Brüderlin, J. (2023). A retroperspective pre-post analysis of changes in the heart rate variability parameters in chronic pain patients performing a 4-week multimodal pain therapy (Master's thesis). Split: University of Split, School of Medicine. Retrieved from https://urn.nsk.hr/urn:nbn:hr:171:531537

Brüderlin, Jakob. "A retroperspective pre-post analysis of changes in the heart rate variability parameters in chronic pain patients performing a 4-week multimodal pain therapy." Master's thesis, University of Split, School of Medicine, 2023. https://urn.nsk.hr/urn:nbn:hr:171:531537

Brüderlin, Jakob. "A retroperspective pre-post analysis of changes in the heart rate variability parameters in chronic pain patients performing a 4-week multimodal pain therapy." Master's thesis, University of Split, School of Medicine, 2023. https://urn.nsk.hr/urn:nbn:hr:171:531537

Brüderlin, J. (2023). 'A retroperspective pre-post analysis of changes in the heart rate variability parameters in chronic pain patients performing a 4-week multimodal pain therapy', Master's thesis, University of Split, School of Medicine, accessed 03 April 2025, https://urn.nsk.hr/urn:nbn:hr:171:531537

Brüderlin J. A retroperspective pre-post analysis of changes in the heart rate variability parameters in chronic pain patients performing a 4-week multimodal pain therapy [Master's thesis]. Split: University of Split, School of Medicine; 2023 [cited 2025 April 03] Available at: https://urn.nsk.hr/urn:nbn:hr:171:531537

J. Brüderlin, "A retroperspective pre-post analysis of changes in the heart rate variability parameters in chronic pain patients performing a 4-week multimodal pain therapy", Master's thesis, University of Split, School of Medicine, Split, 2023. Available at: https://urn.nsk.hr/urn:nbn:hr:171:531537

Metadata
TitleA retroperspective pre-post analysis of changes in the heart rate variability parameters in chronic pain patients performing a 4-week multimodal pain therapy
Title (croatian)Retrospektivna pre-post analiza promjene parametara varijabilnosti srčanog ritma kod pacijenata s kroničnom boli koji su proveli četverotjednu multimodalnu terapiju boli
AuthorJakob Brüderlin
MentorGeorg Heinrich Breuer (mentor)
Committee memberJohannes Brachmann (predsjednik povjerenstva)
Committee memberGeorg Gerhard Grabenbauer (član povjerenstva)
Committee memberMarino Vilović (član povjerenstva)
GranterUniversity of Split
School of Medicine
Split
Defense date and country2023-07-20, Croatia
Scientific / art field,
discipline and subdiscipline		BIOMEDICINE AND HEALTHCARE
Clinical Medical Sciences
Anesthesiology and Reanimatology
Abstract
Objectives: Previous studies have shown that heart rate variability is reduced in chronic pain patients. The aim of this was to investigate the effects of a 4-week multimodal pain therapy on the heart rate variability parameters in chronic pain patients and whether they will improve. Materials and methods: A retrospective pre post analysis was performed analyzing the HRV records of 30 patients who participated at a 4-week multimodal pain therapy at the Pain Centre of the Regiomed Hospital... More Coburg, Bavaria, Germany in the period of 9 months, from Mai 2022 till January 2023. The HRV parameters collected at the beginning and end of the therapy considered in this study are as follows: heart rate, stress index, high frequency, low frequency, HF/LF ratio, NN50, pNN50. In addition, the cortisol levels were also taken into account for a general stress profile. The collected data was analyzed with JASP (Version 0.17.2.0), and normally distributed data were compared with a paired samples Student T Test, whereas non-normally distributed the Mann-Whitney-U test (Wilcoxon signed- rank). The significance level was set to a P-value of <0.05. Results: The mean age of the study group was 51.2 (±10.17) years, with a minimum of 27 and a maximum of 63 years, and a gender distribution of 24 women and 6 men. Only the data for heart rate followed a normal distribution, all others were non-normally distributed. The statistical pre-post analysis revealed non- significant changes, neither in the HRV-parameters heart rate (P=0.124), stress index (P=0.8), high frequency (P=0.116), low frequency (P=0.136), HF/LF ratio (P=0.715), NN50 (P=0596), pNN50 (P=0.811) nor in the serum cortisol levels (P=0.093). Conclusions: This study came to the result that the hypothesis that the HRV parameters would improve with a 4-week course of multimodal pain therapy must be rejected due to the lack of significant changes. However, the statistical limitations such as small sample size, short duration between measurements, and the subjective nature of pain perception, have to be mentioned. Although non-significant, positive tendencies were observed for SI and cortisol. There is a need for more studies on this topic with improved study design. Less
Abstract (croatian)
Ciljevi: Prethodna istraživanja su pokazala da je varijabilnost srčanog ritma smanjena kod pacijenata s kroničnom boli. Cilj ovog istraživanja bio je ispitati učinke četverotjedne multimodalne terapije boli na parametre varijabilnosti srčanog ritma kod pacijenata s kroničnom boli i provjeriti hoće li se poboljšati. Materijali i metode: Izvršena je retrospektivna pre-post analiza analizirajući zapise HRV-a 30 pacijenata koji su sudjelovali u četverotjednoj multimodalnoj terapiji boli u... More Centru za bol u bolnici Regiomed Coburg, Bavarska, Njemačka, u razdoblju od kolovoza 2022. do veljače 2023. HRV parametri prikupljeni na početku i kraju terapije koji su uzeti u obzir u ovom istraživanju su sljedeći: srčani ritam, indeks stresa, visoka frekvencija, niska frekvencija, HF/LF omjer, NN50, pNN50. Osim toga, razine kortizola također su uzete u obzir za opći profil stresa. Prikupljeni podaci analizirani su pomoću JASP-a (Verzija 0.17.2.0), a normalno distribuirani podaci uspoređivani su uparenim uzorcima t-testom, dok su neregularno distribuirani podaci testirani Mann-Whitney-U testom (Wilcoxonov potpisani rang). Razina značajnosti postavljena je na vrijednost P <0.05. Rezultati: Srednja dob studijske skupine bila je 51,2 (±10,17) godina, s minimalnom dobi od 27 godina i maksimalnom dobi od 63 godine, uz rodnu raspodjelu od 24 žene i 6 muškaraca. Samo podaci o srčanom ritmu imali su normalnu distribuciju, dok su svi ostali bili neregularno distribuirani. Statistička pre-post analiza otkrila je neznačajne promjene, ni u jednom od parametara varijabilnosti srčanog ritma - srčani ritam (P=0,124), indeks stresa (P=0,8), visoka frekvencija (P=0,116), niska frekvencija (P=0,136), HF/LF omjer (P=0,715), NN50 (P=0,596), pNN50 (P=0,811) niti u razinama kortizola u serumu (P=0,093). Zaključak: Ovo istraživanje je došlo do rezultata da se hipoteza da će se parametri varijabilnosti srčanog ritma poboljšati četverotjednim tečajem multimodalne terapije boli mora odbaciti zbog nedostatka značajnih promjena. Međutim, treba napomenuti statistička ograničenja kao što su mali uzorak, kratko vrijeme između mjerenja i subjektivna priroda percepcije boli. Iako nisu značajni, primijećene su pozitivne tendencije za indeks stresa (SI) i kortizol. Potrebno je provesti više studija na ovu temu s poboljšanim dizajnom istraživanja. Less
Keywords
Keywords (croatian)
Languageenglish
URN:NBNurn:nbn:hr:171:531537
Study programmeTitle: Medical Studies in English
Study programme type: university
Study level: integrated undergraduate and graduate
Academic / professional title: doktor/doktorica medicine (doktor/doktorica medicine)
Type of resourceText
File originBorn digital
Access conditionsOpen access
Terms of useLicence In copyright icon
Created on2023-07-13 12:40:32
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