prikaz prve stranice dokumenta Ispitivanje učinka intervencije u iritativnom kontaktnom dermatitisu : randomizirano kontrolirano kliničko istraživanje
  Download
PDF 10.27 MB
master's thesis
Ispitivanje učinka intervencije u iritativnom kontaktnom dermatitisu : randomizirano kontrolirano kliničko istraživanje
Split: University of Split, School of Medicine, 2023. urn:nbn:hr:171:920174
Ivić, Magdalena
University of Split
School of Medicine

Institutional repository: MEFST Repository

Cite this document

Ivić, M. (2023). Ispitivanje učinka intervencije u iritativnom kontaktnom dermatitisu : randomizirano kontrolirano kliničko istraživanje (Master's thesis). Split: University of Split, School of Medicine. Retrieved from https://urn.nsk.hr/urn:nbn:hr:171:920174

Ivić, Magdalena. "Ispitivanje učinka intervencije u iritativnom kontaktnom dermatitisu : randomizirano kontrolirano kliničko istraživanje." Master's thesis, University of Split, School of Medicine, 2023. https://urn.nsk.hr/urn:nbn:hr:171:920174

Ivić, Magdalena. "Ispitivanje učinka intervencije u iritativnom kontaktnom dermatitisu : randomizirano kontrolirano kliničko istraživanje." Master's thesis, University of Split, School of Medicine, 2023. https://urn.nsk.hr/urn:nbn:hr:171:920174

Ivić, M. (2023). 'Ispitivanje učinka intervencije u iritativnom kontaktnom dermatitisu : randomizirano kontrolirano kliničko istraživanje', Master's thesis, University of Split, School of Medicine, accessed 23 November 2024, https://urn.nsk.hr/urn:nbn:hr:171:920174

Ivić M. Ispitivanje učinka intervencije u iritativnom kontaktnom dermatitisu : randomizirano kontrolirano kliničko istraživanje [Master's thesis]. Split: University of Split, School of Medicine; 2023 [cited 2024 November 23] Available at: https://urn.nsk.hr/urn:nbn:hr:171:920174

M. Ivić, "Ispitivanje učinka intervencije u iritativnom kontaktnom dermatitisu : randomizirano kontrolirano kliničko istraživanje", Master's thesis, University of Split, School of Medicine, Split, 2023. Available at: https://urn.nsk.hr/urn:nbn:hr:171:920174

Metadata
TitleIspitivanje učinka intervencije u iritativnom kontaktnom dermatitisu : randomizirano kontrolirano kliničko istraživanje
Title (english)Testing the effectiveness of an intervention in irritant contact dermatitis : a randomized controlled trial
AuthorMagdalena Ivić
MentorJosipa Bukić (mentor)
Committee memberDoris Rušić (predsjednik povjerenstva)
Committee memberJoško Božić (član povjerenstva)
Committee memberDario Leskur (član povjerenstva)
GranterUniversity of Split
School of Medicine
Split
Defense date and country2023-07-14, Croatia
Scientific / art field,
discipline and subdiscipline		BIOMEDICINE AND HEALTHCARE
Pharmacy
Pharmacy
Abstract
Cilj istraživanja: Cilj ovog istraživanje bio je utvrditi pokazuje li krema s omega 3 masnim kiselinama obnavljajuće učinke na kožu u ljudskom modelu ICD-a izazvanog SLS-om te istražiti potencijalne nuspojave njene primjene. Materijal i metode: Ovo istraživanje bilo je randomizirani kontrolirani pokus u kojemu je sudjelovalo 25 zdravih, odraslih osoba bez povijesti kožnih bolesti. Provedeno je u lipnju 2023. godine na Medicinskom fakultetu Sveučilišta u Splitu. Na podlakticama ispitanika izazvan je iritativni kontaktni dermatitis koristeći otopinu SLS-a. Kao terapija na jednoj je podlaktici korištena krema s omega kiselinama dok na drugoj nije korištena terapija. Tri kožna parametra mjerena su neinvazivnom bioinženjerskom metodom pomoću uređaja MPA6 (Courage + Khazaka GmBH, Koln, Njemačka). Mjereni parametri bili su transepidermalni gubitak vlage (engl. transepidermal water loss, TEWL), eritem i vlažnost kože. Nakon mjerenja kožnih parametara, ispitanike se pitalo za subjektivne dojmove korištenja kreme te za potencijalne nuspojave. Istraživanje je trajalo 11 dana unutar kojih je provedeno ukupno 7 mjerenja. Rezultati: Korištenje kreme s omega 3 masnim kiselinama pokazalo je najveću razliku u mjerenjima vlažnosti kože, posebno posljednji dan mjerenja kada je zabilježena statistički značajna razlika između skupine koja je koristila omega 3 kremu, 45,72 AU te kontrolne skupine, 31,58 AU, p < 0,001. Zabilježeno je i smanjenje vrijednosti TEWL-a u ispitivanoj skupini. U mjerenjima eritema nisu pronađene statistički značajne razlike. Krema nije izazvala nuspojave u ispitivanoj skupini. Zaključak: Pokus je pokazao da krema s omega 3 masnim kiselinama pozitivno utječe na kožne parametre u modelu SLS induciranog kontaktnog dermatitisa. Kako bi se dobili objektivniji zaključci, potrebno je provesti još istraživanja na istu temu.
Abstract (english)
contact dermatitis: a randomized controlled trial. Objectives: To determine if the cream containing omega 3 fatty acids shows restorative effects on the skin in SLS-induced ICD and to examine the possible side effects of the cream. Materials and methods: The research was a randomized controlled trial. The participants were 25 healthy adults with no history of skin disease. The research was conducted in June of 2023 at the School of Medicine of the University of Split. The model of irritant contact dermatitis was induced on the forearms of the participants using SLS. The skin of one forearm was treated with a cream containing omega 3 fatty acids while the other forearm was left untreated. Three skin parameters were measured using non-invasive bioengineering technique by using MPA 6 device (Courage + Khazaka GmBH, Cologne, Germany). Tested skin parameters included TEWL, erythema and skin hydration. The participants were also asked about the possible side effects they might have experienced while using the cream. Each skin parameter was examined 7 times and the study lasted 11 days. Results: The greatest improvement was noted in skin hydration measurements, especially last day of measurement where the statistically significant difference was noted between the group that used the omega cream, 45,72 AU and the control group, 31,59 AU, p<0,001. The improvement in TEWL values was also noted. The cream did not improve erythema and did not cause any side effects. Conclusion: The study showed that the cream containing omega 3 fatty acids has positive effects on skin parameters in the model of SLS-induced contact dermatitis. Additional research is needed to gain more objective conclusions.
Keywords
Keywords (english)
Languagecroatian
URN:NBNurn:nbn:hr:171:920174
Study programmeTitle: Medicine
Study programme type: university
Study level: integrated undergraduate and graduate
Academic / professional title: doktor/doktorica medicine (doktor/doktorica medicine)
Type of resourceText
File originBorn digital
Access conditionsOpen access
Terms of useLicence In copyright icon
Created on2023-07-14 07:05:42