| Abstract | Cilj: Glavni cilj istraživanja je bio usporediti aktivnost SAA-e u bolesnika s OLP-om u
odnosu na zdrave kontrolne ispitanike. Ostali ciljevi bili su odrediti najčešće lokalizacije
OLP-a, razinu depresije, anksioznosti, stresa te kvalitetu života kod svih ispitanika. Dodatni
ciljevi su bili odrediti duljinu trajanja bolesti i intenzitet simptoma (bol/pečenje) u oboljelih,
te usporediti sve navedene parametre između ispitne i kontrolne skupine te unutar samih
skupina.
Materijali i metode: U istraživanju je sudjelovalo ukupno 50 ispitanika podijeljenih u dvije
skupine. Ispitnu skupinu (N=30) su činili bolesnici s potvrđenom dijagnozom OLP-a.
Kontrolna skupina se sastojala od 20 ispitanika. Bolesnicima s OLP-om je zabilježen oblik
bolesti (neerozivni, erozivni), duljina trajanja bolesti (mjeseci), intenzitet simptoma (VAS
ljestvica). Svim ispitanicima je izmjerena aktivnost SAA-e (kinetičkom kolorimetrijskom
metodom), određen psihološki profil (DASS-21) i kvaliteta života (OHIP-CRO14).
Rezultati: Nije uočena statistički značajna razlika aktivnosti SAA-e u bolesnika s OLP-om u
odnosu na zdrave kontrolne ispitanike (P = 0,314). Najčešće lokalizacije OLP-a su bile
sluznica obraza desno (SZO19) i sluznica obraza lijevo (SZO20). Pokazana je dobra
pozitivna statistički značajna korelacija kvalitete života (ukupno) s intenzitetom simptoma (r
= 0,584, P < 0,001) i depresijom (r = 0,651, P < 0,001), anksioznosti (r = 0,653, P < 0,001),
stresom (r = 0,578, P < 0,001). Pokazana je statistički značajna razlika subsklale OHIPCRO14 fizička bol između bolesnika s erozivnim oblikom OLP-a u odnosu na neerozivni
(2,7±2,3 naspram 0,8±1,3, P = 0,012).
Zaključak: Bolesnici s OLP-om pokazuju znatno više vrijednosti depresije, anksioznosti,
stresa u odnosu na kontrolne ispitanike. Naše istraživanje je pokazalo snažnu povezanost
psihičkih poremećaja i kvalitete života u bolesnika s OLP-om. Možemo zaključiti da je
interdisciplinarni psihoneuroimunološki pristup nužan u bolesnika s OLP-om neovisno jesu li
psihički poremećaji dio etiološkog mehanizma bolesti ili su njegova posljedica. |
| Abstract (english) | Objectives: The main objective of the study was to compare the activity of SAA in patients
with OLP compared with control subjects. Other objectives were to determine the most
common topography of OLP, the level of depression, anxiety, stress, and quality of life in all
subjects. Specific objectives were to determine the disease duration and the intensity of
symptoms (pain/burning) in patients with OLP and to compare all the above parameters
between the test and control groups and within the groups themselves.
Materials and Methods: A total of 50 subjects, divided into two groups, participated in the
cross-sectional study. The test group (N=30) consisted of patients diagnosed with OLP. The
control group consisted of 20 subjects. In the patients with OLP, the form of the disease (nonerosive, erosive), the disease duration (months), the intensity of the symptoms (VAS scale)
were recorded. In all subjects, SAA activity (using the kinetic colorimetric method),
psychological profile (DASS-21) and quality of life (OHIP-CRO14) were determined.
Results: There was no statistically significant difference in SAA activity in patients with
OLP compared to control subjects (P = 0.314). The most frequent topography of OLP were
the mucosa of the right cheek (SZO19) and the mucosa of the left cheek (SZO20). There was
a good positive statistically significant correlation of quality of life (total) with symptom
intensity (r = 0.584, P < 0.001) and depression (r = 0.651, P < 0.001), anxiety (r = 0.653, P <
0.001), stress (r = 0.578, P < 0.001). There was a statistically significant difference in the
OHIP-CRO14 physical pain subscale between patients with an erosive form of OLP
compared to a non-erosive form (2.7±2.3 vs. 0.8±1.3, P = 0.012).
Conclusion: Patients with OLP had significantly higher scores for depression, anxiety, and
stress compared with control subjects. Our cross-sectional study showed a strong association
between mental disorders and quality of life in patients with OLP. We can conclude that an
interdisciplinary psychoneuroimmunological approach is necessary in patients with OLP,
regardless of whether mental disorders are part of the etiological mechanism of the disease or
its consequence. |
