prikaz prve stranice dokumenta Impact of left atrial fibrosis tissue before and induced scar tissue after pulmonary vein isolation on left atrial function detected using cardiac-MRI in patients with atrial fibrillation
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master's thesis
Impact of left atrial fibrosis tissue before and induced scar tissue after pulmonary vein isolation on left atrial function detected using cardiac-MRI in patients with atrial fibrillation
Split: University of Split, School of Medicine, 2023. urn:nbn:hr:171:327579
Zuber, Mariella Franziska Andrea
University of Split
School of Medicine

Institutional repository: MEFST Repository

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Zuber, M. F. A. (2023). Impact of left atrial fibrosis tissue before and induced scar tissue after pulmonary vein isolation on left atrial function detected using cardiac-MRI in patients with atrial fibrillation (Master's thesis). Split: University of Split, School of Medicine. Retrieved from https://urn.nsk.hr/urn:nbn:hr:171:327579

Zuber, Mariella Franziska Andrea. "Impact of left atrial fibrosis tissue before and induced scar tissue after pulmonary vein isolation on left atrial function detected using cardiac-MRI in patients with atrial fibrillation." Master's thesis, University of Split, School of Medicine, 2023. https://urn.nsk.hr/urn:nbn:hr:171:327579

Zuber, Mariella Franziska Andrea. "Impact of left atrial fibrosis tissue before and induced scar tissue after pulmonary vein isolation on left atrial function detected using cardiac-MRI in patients with atrial fibrillation." Master's thesis, University of Split, School of Medicine, 2023. https://urn.nsk.hr/urn:nbn:hr:171:327579

Zuber, M. F. A. (2023). 'Impact of left atrial fibrosis tissue before and induced scar tissue after pulmonary vein isolation on left atrial function detected using cardiac-MRI in patients with atrial fibrillation', Master's thesis, University of Split, School of Medicine, accessed 29 July 2024, https://urn.nsk.hr/urn:nbn:hr:171:327579

Zuber MFA. Impact of left atrial fibrosis tissue before and induced scar tissue after pulmonary vein isolation on left atrial function detected using cardiac-MRI in patients with atrial fibrillation [Master's thesis]. Split: University of Split, School of Medicine; 2023 [cited 2024 July 29] Available at: https://urn.nsk.hr/urn:nbn:hr:171:327579

M. F. A. Zuber, "Impact of left atrial fibrosis tissue before and induced scar tissue after pulmonary vein isolation on left atrial function detected using cardiac-MRI in patients with atrial fibrillation", Master's thesis, University of Split, School of Medicine, Split, 2023. Available at: https://urn.nsk.hr/urn:nbn:hr:171:327579

Metadata
TitleImpact of left atrial fibrosis tissue before and induced scar tissue after pulmonary vein isolation on left atrial function detected using cardiac-MRI in patients with atrial fibrillation
Title (croatian)Utjecaj fibroznog tkiva lijevog atrija prije i induciranog ožiljnog tkiva nakon izolacije plućne vene na funkciju lijevog atrija otkriven pomoću MRI srca u bolesnika s fibrilacijom atrija
AuthorMariella Franziska Andrea Zuber
MentorJohannes Brachmann (mentor)
Committee memberSigrun Renate Merger (predsjednik povjerenstva)
Committee memberPeter Georg Dahlem (član povjerenstva)
Committee memberMarino Vilović (član povjerenstva)
GranterUniversity of Split
School of Medicine
Split
Defense date and country2023-09-01, Croatia
Scientific / art field,
discipline and subdiscipline		BIOMEDICINE AND HEALTHCARE
Clinical Medical Sciences
Internal Medicine
Abstract
Objectives: The aim of this study is to determine the influence of atrial fibrosis before and induced scar tissue after PVI on the left atrial function in patients with paroxysmal AF. Materials and methods: 30 patients from the cardiology department of REGIOMED Hospital in Coburg, Germany, were included in this retrospective, non-invasive and non-randomized study, using data collected between June 2021 and June 2022. Inclusion criteria comprised high-quality MRI scans, sinus rhythm during both pre-MRI and post-MRI, and initial ablation between both MRI scans. At first, we analyzed patient characteristics. For age and BMI, we calculated the mean, median and range. Furthermore, we looked at the cine sequences and measured the LA function by using CVI 42. The next step was detecting the LA fibrosis before PVI and observing the LA induced scar tissue 3 months after PVI by analyzing MRI scans. In addition, the LA volume before and after PVI was analyzed. For this, the Merisight software was used. The collected data was analyzed with JASP (Version 0.17.2.0). The distribution was measured with mean, median, skewness and kurtosis. Afterwards we correlated our measured LA fibrosis/induced scar tissue with LAEF with the Pearson´s correlation test. We measured the association between LAEF and volume, both pre- and post-PVI, with the paired sample t- test. The significance level was set to a P-value of <0.05. Results: All of our variables had an approximate normal distribution. There was no correlation observed between LAEF pre-PVI and LA fibrosis (P=0.187), nor between LAEF post-PVI and LA fibrosis (P=0.328). However, the Pearson´s correlation coefficient did suggest that larger LA fibrosis could correspond to lower LAEF and vice versa. In addition, no correlation between LAEF post PVI and LA induced scar tissue was observed (P=0.655). Furthermore, no association between EF before and after PVI was found (P=0.485). In contrast, a significant connection between LA volume (P=0.012) before and after PVI was noticed. It showed a significant decrease of volume after PVI, which may indicate an improvement of LA anatomy after PVI. Conclusions: In conclusion, this retrospective study primarily focused on exploring the correlation between atrial fibrosis/atrial induced scar tissue and atrial function. Our findings revealed no significant correlation between these factors. Consequently, our hypothesis suggesting an influence of atrial fibrosis and atrial induced scar tissue on left atrial function can be rejected. Furthermore, the analysis of the association between LAEF before and after PVI indicated no statistically significance. However, the association between LA volume before and after PVI demonstrated a significant reduction of volume, which may indicate an improvement of LA anatomy after PVI.
Abstract (croatian)
Ciljevi: Cilj ove studije je utvrditi utjecaj atrijalne fibroze prije i inducirane ožiljne tkivu nakon PVI na funkciju lijevog atrija kod bolesnika s paroksizmalnom fibrilacijom atrija. Materijali i metode: U ovoj retrospektivnoj, neinvazivnoj i ne-randomiziranoj studiji uključeno je 30 pacijenata iz kardiološkog odjela REGIOMED bolnice u Coburgu, Njemačka, koristeći podatke prikupljene između lipnja 2021. i lipnja 2022. Kriteriji za uključivanje obuhvaćali su visokokvalitetne MRI snimke, sinusni ritam tijekom obje pre-MRI i post-MRI faze te početnu ablacija između obje MRI snimke. Prvo smo analizirali karakteristike pacijenata. Za dob i indeks tjelesne mase (BMI) izračunali smo srednju vrijednost, medijanu i raspon. Nadalje, analizirali smo filmske sekvence i mjerili funkciju lijevog atrija koristeći CVI 42. Sljedeći korak bio je detektiranje fibroze lijevog atrija prije PVI i promatranje induciranog ožiljnog tkiva 3 mjeseca nakon PVI analizom MRI snimaka. Dodatno, volumen lijevog atrija prije i poslije PVI-a je analiziran. Za to smo koristili Merisight softver. Prikupljeni podaci analizirani su uz pomoć JASP-a (verzija 0.17.2.0). Distribucija je izmjerena pomoću srednje vrijednosti, mediane, asimetrije i ekscesa. Zatim smo korelirali našu izmjerenu fibrozu lijevog atrija/inducirano ožiljno tkivo s LAEF pomoću Pearsonovog koeficijenta korelacije. Mjerili smo povezanost između LAEF i volumena, i prije i poslije PVI, pomoću uparenog uzorka t- testa. Razina značajnosti postavljena je na P-vrijednost <0,05. Rezultati: Svi naši varijable imali su približno normalnu distribuciju. Nije uočena korelacija između LAEF prije PVI i fibroze lijevog atrija (P=0,187), niti između LAEF nakon PVI i fibroze lijevog atrija (P=0,328). Međutim, Pearsonov koeficijent korelacije sugerira da veća fibroza lijevog atrija može odgovarati nižem LAEF i obrnuto. Nadalje, nije uočena korelacija između LAEF nakon PVI i induciranog ožiljnog tkiva lijevog atrija (P=0,655). Nadalje, nije pronađena povezanost između EF prije i nakon PVI (P=0,485). Nasuprot tome, primijećena je značajna veza između volumena lijevog atrija (P=0,012) prije i nakon PVI. Pokazano je značajno smanjenje volumena nakon PVI, što može ukazivati na poboljšanje anatomije lijevog atrija nakon PVI. Zaključak: U zaključku, ova retrospektivna studija prvenstveno je istraživala korelaciju između atrijalne fibroze/induciranog ožiljnog tkiva i funkcije atrija. Naši rezultati nisu pokazali značajnu korelaciju između ovih faktora. Stoga se može odbaciti naša hipoteza koja sugerira utjecaj atrijalne fibroze i induciranog ožiljnog tkiva na funkciju lijevog atrija. Nadalje, analiza povezanosti između LAEF prije i nakon PVI nije ukazala na statističku značajnost. Međutim, povezanost između volumena lijevog atrija prije i nakon PVI pokazala je značajno smanjenje volumena, što može ukazivati na poboljšanje anatomije lijevog atrija nakon PVI.
Keywords
Keywords (croatian)
Languageenglish
URN:NBNurn:nbn:hr:171:327579
Study programmeTitle: Medical Studies in English
Study programme type: university
Study level: integrated undergraduate and graduate
Academic / professional title: doktor/doktorica medicine (doktor/doktorica medicine)
Type of resourceText
File originBorn digital
Access conditionsOpen access
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Created on2023-09-06 08:13:10