prikaz prve stranice dokumenta Razlike u distribuciji živčanih vlakana i upalnog infiltrata u genitalnoj i ekstragenitalnoj varijanti bolesti lichen sclerosus
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doctoral thesis
Razlike u distribuciji živčanih vlakana i upalnog infiltrata u genitalnoj i ekstragenitalnoj varijanti bolesti lichen sclerosus
Split: University of Split, School of Medicine, 2023. urn:nbn:hr:171:903201
Vuković, Dubravka
University of Split
School of Medicine

Institutional repository: MEFST Repository

Cite this document

Vuković, D. (2023). Razlike u distribuciji živčanih vlakana i upalnog infiltrata u genitalnoj i ekstragenitalnoj varijanti bolesti lichen sclerosus (Doctoral thesis). Split: University of Split, School of Medicine. Retrieved from https://urn.nsk.hr/urn:nbn:hr:171:903201

Vuković, Dubravka. "Razlike u distribuciji živčanih vlakana i upalnog infiltrata u genitalnoj i ekstragenitalnoj varijanti bolesti lichen sclerosus." Doctoral thesis, University of Split, School of Medicine, 2023. https://urn.nsk.hr/urn:nbn:hr:171:903201

Vuković, Dubravka. "Razlike u distribuciji živčanih vlakana i upalnog infiltrata u genitalnoj i ekstragenitalnoj varijanti bolesti lichen sclerosus." Doctoral thesis, University of Split, School of Medicine, 2023. https://urn.nsk.hr/urn:nbn:hr:171:903201

Vuković, D. (2023). 'Razlike u distribuciji živčanih vlakana i upalnog infiltrata u genitalnoj i ekstragenitalnoj varijanti bolesti lichen sclerosus', Doctoral thesis, University of Split, School of Medicine, accessed 17 May 2024, https://urn.nsk.hr/urn:nbn:hr:171:903201

Vuković D. Razlike u distribuciji živčanih vlakana i upalnog infiltrata u genitalnoj i ekstragenitalnoj varijanti bolesti lichen sclerosus [Doctoral thesis]. Split: University of Split, School of Medicine; 2023 [cited 2024 May 17] Available at: https://urn.nsk.hr/urn:nbn:hr:171:903201

D. Vuković, "Razlike u distribuciji živčanih vlakana i upalnog infiltrata u genitalnoj i ekstragenitalnoj varijanti bolesti lichen sclerosus", Doctoral thesis, University of Split, School of Medicine, Split, 2023. Available at: https://urn.nsk.hr/urn:nbn:hr:171:903201

Metadata
TitleRazlike u distribuciji živčanih vlakana i upalnog infiltrata u genitalnoj i ekstragenitalnoj varijanti bolesti lichen sclerosus
Title (english)Differences in the distribution of nerve fibers and inflammatory infiltrate in genital and extragenital variants of lichen sclerosus
AuthorDubravka Vuković
MentorSnježana Mardešić (mentor)
Committee memberNatalija Filipović (predsjednik povjerenstva)
Committee memberSnježana Tomić (član povjerenstva)
Committee memberTonči Stipić (član povjerenstva)
GranterUniversity of Split
School of Medicine
Split
Defense date and country2023-08-28, Croatia
Scientific / art field,
discipline and subdiscipline		BIOMEDICINE AND HEALTHCARE
Clinical Medical Sciences
Dermatovenerology
Universal decimal classification
(UDC)		616 - Pathology. Clinical medicine
Abstract
Lichen sclerosus (LS) progresivna je kožna bolest koju karakterizira kronična upala genitalne ili ekstragenitalne kože, a nesrazmjerno češće pogađa žene. Imunohistokemijski smo analizirali raspodjelu živčanih vlakana, vaniloidnih receptora te biljege stanične proliferacije, apoptoze, mastocita i makrofaga u genitalnim i ekstragenitalnim uzorcima LS-a, kao i u zdravoj koži. Ukupna količina intraepidermalnih živčanih vlakana bila je manja u uzorcima kože bolesnica oboljelih od LS-a u usporedbi sa zdravim kontrolama, a ukupna je količina subepidermalnih živčanih vlakana i vlakana pozitivnih na peptid povezan s genom-kalcitonina (engl. calcitonin gene-related peptide, CGRP) bila viša u uzorcima genitalne kože oboljelih od LS-a u usporedbi s uzorcima bolesnica s ekstragenitalnim LS-om i zdravim kontrolama. Proliferacija stanica te gustoća makrofaga i mastocita bila je povećana u uzorcima LS-a u usporedbi sa zdravim kontrolama. Uzorci genitalnog LS-a imali su veću gustoću makrofaga u usporedbi s ekstragenitalnom varijantom. Raspodjela mastocita značajno se razlikovala između genitalnih i ekstragenitalnih uzoraka LS-a iako nije bilo razlike u ukupnoj gustoći mastocita. Apoptoza epidermalnih stanica bila je najizraženija u uzorcima genitalne kože bolesnica oboljelih od LS-a. Ova bi otkrića mogla objasniti razlike u jačini svrbeža genitalnog i ekstragenitalnog oblika LS-a i pružiti ciljeve za istraživanje novih terapijskih strategija za liječenje LS-a.
Abstract (english)
Lichen sclerosus (LS) is a progressive skin disease that is characterized by chronic inflammation of either genital or extragenital skin, and it disproportionately affects women. We analyzed the distribution of nerve fibers, vanilloid receptors, cell proliferation, mast cells and macrophages in genital and extragenital LS samples, as well as in healthy skin, by using immunohistochemistry. The total amount of intraepidermal nerve fibers was lower in LS samples compared to healthy controls, while the total amount of subepidermal nerve fibers and calcitonin gene-related peptide (CGRP) positive fibers was higher in genital LS samples compared to both extragenital LS and healthy controls. Cell proliferation, macrophage and mast cell density were increased in LS samples compared to healthy controls. Genital LS had a higher macrophage density compared to the extragenital variant. Mast cell distribution significantly differed between genital and extragenital LS samples, even though their total mast cell densities were similar. Epidermal cell apoptosis was the most prominent in genital LS samples. These findings could explain the differences between pruritic symptoms of genital and extragenital LS and provide targets for the research of novel therapeutic strategies for LS management.
Keywords
Keywords (english)
Languagecroatian
URN:NBNurn:nbn:hr:171:903201
Promotion2023
Study programmeTitle: Evidence-Based Clinical Medicine
Study programme type: university
Study level: postgraduate
Academic / professional title: doktor/doktorica znanosti, područje biomedicine i zdravstvo (doktor/doktorica znanosti, područje biomedicine i zdravstvo)
Type of resourceText
File originBorn digital
Access conditionsOpen access
Terms of useLicence In copyright icon
Created on2023-09-06 11:25:33