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scientific master's theses
Uloga eksperimentalno izazvane denervacije na morfologiju kože štakora
Split: University of Split, School of Medicine, 2007. urn:nbn:hr:171:263644
Restović-Dujmović, Ivana
University of Split
School of Medicine

Institutional repository: MEFST Repository

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Restović Dujmović, I. (2007). Uloga eksperimentalno izazvane denervacije na morfologiju kože štakora (Scientific master's theses). Split: University of Split, School of Medicine. Retrieved from https://urn.nsk.hr/urn:nbn:hr:171:263644

Restović Dujmović, Ivana. "Uloga eksperimentalno izazvane denervacije na morfologiju kože štakora." Scientific master's theses, University of Split, School of Medicine, 2007. https://urn.nsk.hr/urn:nbn:hr:171:263644

Restović Dujmović, Ivana. "Uloga eksperimentalno izazvane denervacije na morfologiju kože štakora." Scientific master's theses, University of Split, School of Medicine, 2007. https://urn.nsk.hr/urn:nbn:hr:171:263644

Restović Dujmović, I. (2007). 'Uloga eksperimentalno izazvane denervacije na morfologiju kože štakora', Scientific master's theses, University of Split, School of Medicine, accessed 17 July 2024, https://urn.nsk.hr/urn:nbn:hr:171:263644

Restović Dujmović I. Uloga eksperimentalno izazvane denervacije na morfologiju kože štakora [Scientific master's theses]. Split: University of Split, School of Medicine; 2007 [cited 2024 July 17] Available at: https://urn.nsk.hr/urn:nbn:hr:171:263644

I. Restović Dujmović, "Uloga eksperimentalno izazvane denervacije na morfologiju kože štakora", Scientific master's theses, University of Split, School of Medicine, Split, 2007. Available at: https://urn.nsk.hr/urn:nbn:hr:171:263644

Metadata
TitleUloga eksperimentalno izazvane denervacije na morfologiju kože štakora
Title (english)Role of experimentally induced denervation on rat skin morphology
AuthorIvana Restović-Dujmović
MentorDamir Sapunar (mentor)
Committee memberMirna Saraga-Babić (predsjednik povjerenstva)
Committee memberIvo Lušić (član povjerenstva)
Committee memberDamir Sapunar (član povjerenstva)
GranterUniversity of Split
School of Medicine
Split
Defense date and country2007, Croatia
Scientific / art field,
discipline and subdiscipline		BIOMEDICINE AND HEALTHCARE
Basic Medical Sciences
Cytology, Histology and Embryology
Universal decimal classification
(UDC)		61 - Medical sciences
Abstract
Uslijed kompletne denervacije kože dolazi do stanjenja epidermisa. Međutim, nije posve jasno da li slične promjene može izazvati djelomična denervacija kože. U ovom radu, istražili smo utjecaj djelomične denervacije na stanjenje epidermisa šape štakora, utvrdili da li je epidermalno stanjenje jednako na različitim područjima šape, te povezali nastale promjene s ponašanjem životinja. U istraživanju su korištena dva eksperimentalna modela koja izazivaju djelomičnu denervaciju: spinalno podvezivanje živca, SNL model (eng. spinal nerve ligation) i model kronične konstrikcijske ozljede, CCI model (eng. chronic constriction injury). Promjene u debljini epidermisa mjerene su za cijelu šapu i za pojedina područja šape (medijalni, srednji i lateralni dio). Stanjenje epidermisa je bilo statistički značajno u oba primijenjena modela: u SNL modelu (60 ± 17.3µm) i u CCI modelu (59.8 ± 8.1 µm) nasuprot kontrolne skupine (78.2 ± 20.5 µm). Najizraženije stanjenje je uočeno na lateralnoj strani u SNL skupini (55.6 ± 15.5µm vs. 86.9 ± 20.1µm, p < 0.001). Obe skupine životinja, SNL i CCI, su pokazale povećanu vjerojatnost hiperalgezijskog odgovora za vrijeme cijelog postoperativnog razdoblja, dok statistički značajne razlike nije bilo između pojedinih testiranih područja šape. Ovo istraživanje potvrdilo je da parcijalna denervacija izaziva epidermalno stanjenje šape štakora na sličan način kao i kompletna denervacija, ali nisu uočene regionalne razlike u hiperalgezijskom odgovoru pri testiranju različitih dijelova šape.
Abstract (english)
Total denervation of the skin induces regional differences in epidermal thinning. However, it is not clear whether similar differences could be induced by partial denervation of the paw. We investigated relation between changes in epidermal thickness and hyperalgesic behavioral responses in different areas of the rat glaborus skin. Partial denervation was produced using two experimental models of neuropathic pain injury: spinal nerve ligation (SNL) and chronic constriction injury (CCI). The epidermal thickness of denervated epidermis was evaluated in the entire paw and from the medial and lateral regions of the paw. Behavioral response was examined by mechanical stimulation of the medial, middle and lateral sides of the paw. The reduction of epidermal thickness was significant in both models: in SNL model (60 ±17.3µm) and in CCI model (59.8 ± 8.10 µm) vs control group (78.2 ± 20.5 µm). The most obvious thinning was observed in lateral region of SNL group (55.6 ± 15.5µm vs. 86.9 ± 20.1µm, p < 0.001). Both, SNL and CCI operated animals showed the increase in hyperalgesic response during the whole postoperative period without regional differences between testing regions. This study suggest that partial denervation induces epidermal thinning similarly as total denervation of the rat hind paw, but there are no differences in pain-related behavior when testing different sites of paw.
Keywords
Keywords (english)
Languagecroatian
URN:NBNurn:nbn:hr:171:263644
Study programmeTitle: Basic and clinical medical sciences
Study programme type: university
Study level: postgraduate
Academic / professional title: magistar/magistrica znanosti (magistar/magistrica znanosti)
Type of resourceText
File originBorn digital
Access conditionsOpen access
Terms of useLicence In copyright icon
Created on2024-05-02 12:11:32