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master's thesis
Utjecaj čimbenika okoliša na serumsku koncentraciju kalcitonina
Split: University of Split, School of Medicine, 2024. urn:nbn:hr:171:071196
Jurić, Ante
University of Split
School of Medicine

Institutional repository: MEFST Repository

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Jurić, A. (2024). Utjecaj čimbenika okoliša na serumsku koncentraciju kalcitonina (Master's thesis). Split: University of Split, School of Medicine. Retrieved from https://urn.nsk.hr/urn:nbn:hr:171:071196

Jurić, Ante. "Utjecaj čimbenika okoliša na serumsku koncentraciju kalcitonina." Master's thesis, University of Split, School of Medicine, 2024. https://urn.nsk.hr/urn:nbn:hr:171:071196

Jurić, Ante. "Utjecaj čimbenika okoliša na serumsku koncentraciju kalcitonina." Master's thesis, University of Split, School of Medicine, 2024. https://urn.nsk.hr/urn:nbn:hr:171:071196

Jurić, A. (2024). 'Utjecaj čimbenika okoliša na serumsku koncentraciju kalcitonina', Master's thesis, University of Split, School of Medicine, accessed 23 November 2024, https://urn.nsk.hr/urn:nbn:hr:171:071196

Jurić A. Utjecaj čimbenika okoliša na serumsku koncentraciju kalcitonina [Master's thesis]. Split: University of Split, School of Medicine; 2024 [cited 2024 November 23] Available at: https://urn.nsk.hr/urn:nbn:hr:171:071196

A. Jurić, "Utjecaj čimbenika okoliša na serumsku koncentraciju kalcitonina", Master's thesis, University of Split, School of Medicine, Split, 2024. Available at: https://urn.nsk.hr/urn:nbn:hr:171:071196

Metadata
TitleUtjecaj čimbenika okoliša na serumsku koncentraciju kalcitonina
Title (english)The impact of environmental factors on serum calcitonin levels
AuthorAnte Jurić
MentorIvana Gunjača (mentor)
Committee memberMarino Vilović (predsjednik povjerenstva)
Committee memberNikolina Režić Mužinić (član povjerenstva)
Committee memberBenjamin Benzon (član povjerenstva)
GranterUniversity of Split
School of Medicine
Split
Defense date and country2024-07-17, Croatia
Scientific / art field,
discipline and subdiscipline		BIOMEDICINE AND HEALTHCARE
Basic Medical Sciences
Human Physiology
Abstract
CILJ: Cilj ovog istraživanja bio je odrediti povezanost konzumiranja određenih skupina namirnica s koncentracijama kalcitonina (CT) u serumu zdravih pojedinaca. MATERIJALI I METODE: Ova presječna studija obuhvatila je 2500 ispitanika s otoka Korčule. Koncentracije CT-a u serumu određena je radioimunoesej (RIA) metodom u Laboratoriju za biokemiju Kliničkog bolničkog centra Split koristeći komercijalne setove. Podaci su prikupljeni putem upitnika o učestalosti konzumiranja hrane (FFQ). Analiza glavnih komponenti (PCA) korištena je za smanjenje dimenzionalnosti prehrambenih podataka. Bartlettov χ2 test sferičnosti i Kaiser-Meyer-Olkin indeks korišteni su za procjenu prikladnosti uzorka za faktorsku analizu. Povezanost prehrambenih skupina dobivenih PCA metodom s koncentracijama CT-a ispitana je linearnom regresijom, pri čemu su P-vrijednosti manje od 0,05 smatrane statistički značajnima. REZULTATI: Faktorskom analizom identificirano je 19 prehrambenih faktora. Spol je pokazao značajnu povezanost s koncentracijom CT-a, pri čemu su muški ispitanici imali više koncentracije CT-a u serumu u usporedbi sa ženskim ispitanicama. Linearna regresijska analiza pokazala je negativnu povezanost učestale konzumacije lignje, hobotnice i sušene ribe s koncentracijom CT-a u serumu (β = -0,085, SE = 0,138, P = 0,026). Nasuprot tome, učestala konzumacija svježeg i punomasnog sira, tjestenine i riže pokazala je pozitivnu povezanost s koncentracijom CT-a (β = 0,085, SE = 0,139, P = 0,027). ZAKLJUČAK: Prehrana bogata plodovima mora, poput hobotnice, lignje i sušene ribe je povezana s nižim koncentracijama CT-a, dok prehrana s većim unosom sireva, tjestenine i riže je povezana s višim koncentracijama CT-a.
Abstract (english)
OBJECTIVES: The aim of this study was to determine the association of dietary factors with calcitonin (CT) levels in the serum of healthy individuals. MATERIALS AND METHODS: This cross-sectional study included 2,500 participants from the island of Korčula. Serum CT concentrations were determined by the radioimmunoassay (RIA) method in the Biochemistry Laboratory of the University Hospital of Split using commercial kits. Data was collected using a food frequency questionnaire (FFQ). Principal component analysis (PCA) was used to reduce the dimensionality of the dietary data. Bartlett's χ2 test of sphericity and the Kaiser-Meyer-Olkin index were used to assess the suitability of the sample for factor analysis. The association of food groups obtained by the PCA method with CT concentrations was tested by linear regression, whereby P-values less than 0.05 were considered statistically significant. RESULTS: Factor analysis revealed 19 dietary factors. Positive associations were found between CT levels and sex, with males having higher serum CT levels than females. Linear regression analysis showed that frequent consumption of seafood, squid, octopus, and dried fish was negatively associated with serum CT levels (β = -0.085, SE = 0.138, P = 0.026). In contrast, frequent consumption of cheese, pasta, and rice was positively associated with serum CT levels (β = 0.085, SE = 0.139, P = 0.027). CONCLUSION:. Frequent consumption of seafood, octopus, squid, and dried fish was associated with lower CT levels while frequent consumption of cheese, pasta and rice was associated with higher CT levels.
Keywords
Keywords (english)
Languagecroatian
URN:NBNurn:nbn:hr:171:071196
Study programmeTitle: Medicine
Study programme type: university
Study level: integrated undergraduate and graduate
Academic / professional title: doktor/doktorica medicine (doktor/doktorica medicine)
Type of resourceText
File originBorn digital
Access conditionsOpen access
Embargo expiration date: 2024-07-17
Terms of useLicence In copyright icon
Created on2024-07-16 12:07:08