Title Evaluation of the frequency and necessity of proton-pump-inhibitor therapy in geriatric patients Title (croatian) Procjena učestalosti i potrebe terapije inhibitorima protonske pumpe u gerijatrijskih bolesnika Author Anna Laura Emma Müller Mentor Johannes Brachmann (mentor) Committee member Georg Gerhard Grabenbauer (predsjednik povjerenstva) Committee member Georg Heinrich Breuer (član povjerenstva) Committee member Josipa Bukić (član povjerenstva)Granter University of Split Defense date and country 2024-07-18, Croatia Scientific / art field, BIOMEDICINE AND HEALTHCARE Abstract Objectives: The aim of this study was to investigate the usage of proton pump inhibitors in geriatric patients in the general medicine ward. Additionally, the study also looked into polypharmacy among those patients.
Materials and Methods: This retrospective study analyzed medical histories and medication lists of patients in the general medicine ward at Regiomed Klinikum Coburg during June 2019 and June 2023. A convenience sample of 154 geriatric patients was used during the selection process. Admission within the defined time period was required for inclusion. Excluded were patients below the age of 65, patients who died during the hospital stay and those with incomplete data. Data collection focused on demographic and medical information from the admission and discharge forms, like age, gender, medical conditions, PPI use, and number of medications taken. The data was analyzed anonymously to provide a snapshot of prescription patterns and indications. Potential biases included sampling, recall, and information bias.
Results: In 154 geriatric patients, 61% were on PPI therapy during their hospital stay with Pantoprazole 40mg being the most frequently used PPI. Of the patients on PPIs, 63.8% had no documented clinical indication for PPI therapy, constituting 39% of the total sample. In addition, the study found that 44.2% of PPI therapies were long-term without a defined end date. Adverse effects could be suspected in 12.3% of patients. The sample demographics included an average patient age of 85 years, with 70.1% being female and 29.9% being male patients. Polypharmacy was prevalent with 79.9% of patients upon admission, meaning taking more than five medications, and with 90.3% at discharge. The mean number of medications taken was 9. Statistical tests showed no significant association between age, gender, and PPI usage. However, it was found that there may be connections between polymedication and PPI treatment, as well as between indication and PPI.
Conclusion: This study investigated the frequency and necessity of PPI therapy in geriatric patients, revealing that 61% were on PPI therapy. The majority of those who used PPIs did not have a documented clinical indication. Long-term therapy was particularly prevalent, raising concerns about potential adverse effects. Furthermore, significant polypharmacy was found. In order to guarantee the safe and proper use of PPIs in the older population, this study emphasized the necessity of improved prescribing practices and regular medication reviews.
Abstract (croatian) Ciljevi: Cilj ovog istraživanja bio je pregledati podatke gerijatrijskih bolesnika na odjelu opće medicine kako bi se analizirala njihova upotreba inhibitora protonske pumpe. Osim toga, istraživanje ispituje polifarmaciju među tim pacijentima.
Materijali i metode: Ovo retrospektivno istraživanje pregledalo je medicinske povijesti i popise lijekova bolesnikana odjelu opće medicine u bolnici Coburg unutar određenog vremenskog okvira od lipnja 2019. do lipnja 2023. Ukupno je 154 gerijatrijskih pacijenata odabrano prigodnim uzorkovanjem. Kriterij za uključivanje bio je prijem unutar definiranog vremenskog razdoblja. Isključeni su bolesnici mlađi od 65 godina, bolesnici koji su umrli tijekom boravka u bolnici i oni s nepotpunim podacima. Prikupljanje podataka fokusiralo se na demografske i medicinske informacije iz prijemnih i otpustnih obrazaca, poput dobi, spola, medicinskih stanja, upotrebe PPI-a i broja uzetih lijekova. Podaci su analizirani anonimno kako bi se dobio pregled obrazaca propisivanja i indikacija. Potencijalne pristranosti uključuju pristranost uzorkovanja, prisjećanja i informacija.
Rezultati: Od 154 gerijatrijskih pacijenata, 61% je bilo na PPI terapiji tijekom boravka u bolnici, pri čemu je Pantoprazol 40 mg bio najčešće korišteni PPI. 63.8% pacijenata koji su uzimali PPI nisu imali dokumentiranu kliničku indikaciju za PPI terapiju, što je 39% ukupnog uzorka. Studija je također otkrila da je 44,2% PPI terapija bilo dugotrajno, bez definiranog krajnjeg datuma. Nuspojave su se mogle sumnjati kod 12,3% pacijenata. Demografski podaci uzorka uključivali su prosječnu dob pacijenta od 85 godina, s 70,1% ženskih i 29,9% muških pacijenata. Polifarmacija je bila prisutna u 79,9% pacijenata pri prijemu, što znači da su uzimali više od pet lijekova, te kod 90,3% pri otpustu. Prosječan broj uzetih lijekova bio je 9. Statistički testovi nisu pokazali značajnu korelaciju između dobi, spola i upotrebe PPI-a. Međutim, moguće veze pronađene su između polimedikacije i PPI terapije, kao i između indikacije i PPI.
Zaključak: Ovo istraživanje ispitivalo je učestalost i potrebu za PPI terapijom kod gerijatrijskih pacijenata, otkrivajući da je 61% bilo na PPI terapiji. Većina tih pacijenata nije imala dokumentiranu kliničku indikaciju za upotrebu PPI-a. Dugotrajna terapija bila je posebno česta, što je izazvalo zabrinutost zbog mogućih nuspojava. Osim toga, otkrivena je značajna polifarmacija. Rezultati istraživanja istaknuli su potrebu za poboljšanim praksama propisivanja i redovitim pregledom lijekova kako bi se osigurala sigurna i odgovarajuća upotreba PPI-a u starijoj populaciji.
Keywords
Proton-pump inhibitors
Geriatric patients
Polypharmacy
Keywords (croatian)
inhibitori protonske pumpe
stariji bolesnici
polifarmacija
Language english URN:NBN urn:nbn:hr:171:616029 Study programme Title: Medical Studies in English Type of resource Text File origin Born digital Access conditions Open access Terms of use Created on 2024-07-17 09:57:13
