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master's thesis
Primjena terapijske izmjene plazme u djece liječene u Kliničkom bolničkom centru Split
Split: University of Split, School of Medicine, 2024. urn:nbn:hr:171:989668
Kotarac, Mihaela
University of Split
School of Medicine

Institutional repository: MEFST Repository

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Kotarac, M. (2024). Primjena terapijske izmjene plazme u djece liječene u Kliničkom bolničkom centru Split (Master's thesis). Split: University of Split, School of Medicine. Retrieved from https://urn.nsk.hr/urn:nbn:hr:171:989668

Kotarac, Mihaela. "Primjena terapijske izmjene plazme u djece liječene u Kliničkom bolničkom centru Split." Master's thesis, University of Split, School of Medicine, 2024. https://urn.nsk.hr/urn:nbn:hr:171:989668

Kotarac, Mihaela. "Primjena terapijske izmjene plazme u djece liječene u Kliničkom bolničkom centru Split." Master's thesis, University of Split, School of Medicine, 2024. https://urn.nsk.hr/urn:nbn:hr:171:989668

Kotarac, M. (2024). 'Primjena terapijske izmjene plazme u djece liječene u Kliničkom bolničkom centru Split', Master's thesis, University of Split, School of Medicine, accessed 03 October 2024, https://urn.nsk.hr/urn:nbn:hr:171:989668

Kotarac M. Primjena terapijske izmjene plazme u djece liječene u Kliničkom bolničkom centru Split [Master's thesis]. Split: University of Split, School of Medicine; 2024 [cited 2024 October 03] Available at: https://urn.nsk.hr/urn:nbn:hr:171:989668

M. Kotarac, "Primjena terapijske izmjene plazme u djece liječene u Kliničkom bolničkom centru Split", Master's thesis, University of Split, School of Medicine, Split, 2024. Available at: https://urn.nsk.hr/urn:nbn:hr:171:989668

Metadata
TitlePrimjena terapijske izmjene plazme u djece liječene u Kliničkom bolničkom centru Split
Title (english)Therapeutic plasma exchange (TPE) in children treated at the University Hospital of Split
AuthorMihaela Kotarac
MentorTanja Kovačević (mentor)
Committee memberRenata Pecotić (predsjednik povjerenstva)
Committee memberBranka Polić (član povjerenstva)
Committee memberZenon Pogorelić (član povjerenstva)
GranterUniversity of Split
School of Medicine
Split
Defense date and country2024-09-23, Croatia
Scientific / art field,
discipline and subdiscipline		BIOMEDICINE AND HEALTHCARE
Clinical Medical Sciences
Pediatrics
Abstract
Cilj istraživanja: Cilj istraživanja je bio utvrditi razdiobu indikacija zbog kojih se djeca u Kliničkom bolničkom centru Split upućuju na terapijsku izmjenu plazme (TPE od engl. Therapeutic plasma exchange) te procijeniti sigurnost i učinkovitost ove terapije prateći komplikacije i broj provedenih postupaka, dugotrajne ishode liječenja te duljinu bolničkog liječenja. Ispitanici i metode: U istraživanje su uključeni svi bolesnici kojima je provedena, u bilo kojem trenutku bolničkog liječenja u Klinici za dječje bolesti, TPE. Istraživanje je obuhvatilo period od 1. svibnja 2014. do 30. travnja 2024. Iz medicinske dokumentacije prikupljeni su podaci o liječenju i potom statistički obrađeni. Rezultati: Ukupno je provedeno 445 postupaka TPE u 64 ispitanika. Najčešće je postupak TPE izveden tijekom jednog ciklusa, a sastojao se od pet do 10 pojedinačnih TPE. Za provođenje TPE najčešće je postavljen središnji venski kateter u desnu unutarnju jugularnu venu (82%). Prosječna duljina bolničkog liječenja bila je 29 ± 20 dana. Od ukupnog broja ispitanika 43 (67%) ih nije zahtijevalo intenzivno liječenje u Zavodu za intenzivnu pedijatriju, dok ostali jesu zbog životno ugrožavajućih stanja. Indikacije za provođenje TPE najčešće su bile neurološke u 53 (83%), potom nefrološke u 7 (11%) bolesnika, slijedila su različita otrovanja i u jednom slučaju akutno zatajenje jetre. Većina bolesnika nije imala komplikacije vezane uz TPE (47%). Statističkom obradom podataka nisu utvrđeni prediktori ni dugoročnih ishoda niti komplikacija liječenja. Zaključak: Postupak TPE se najčešće provodio u slučajevima neuroloških indikacija. Rezultati našeg istraživanja pokazali su da broj TPE postupaka, komplikacije i liječenje u Zavodu za intenzivnu pedijatriju nisu značajni prediktori dugoročnih ishoda u pedijatrijskih bolesnika. TPE se pokazao kao siguran postupak, s rijetkim komplikacijama koje nisu imale značajan utjecaj na dugotrajan ishod liječenja. Dugoročni rezultati najvjerojatnije ovise o osnovnoj bolesti i individualnom odgovoru bolesnika na terapiju.
Abstract (english)
Objectives: The aim of the research was to determine the distribution of indications for which children were referred for TPE at the University Hospital of Split and to assess the safety and effectiveness of this therapy by monitoring complications and the number of procedures performed, the final outcomes of treatment and the length of hospital treatment. Materials and methods: The study included all patients who underwent TPE any time during their hospitalization in the Department of Paediatrics from 1st May 2014 to 30th April 2024. Treatment data were collected from medical records and then statistically processed. Results: A total of 445 TPE procedures were performed in 64 subjects. Most often, the TPE procedure was performed during one cycle, consisting of five to 10 individual TPEs. To perform TPE, a central venous catheter was usually placed in the right internal jugular vein (82%). The average length of hospital treatment was 29 ± 20 days. Out of the total number, 43 (67%) patients did not require treatment in the Paediatric intensive care unit (PICU), while the rest did. Most of the indications for performing TPE were neurological in 53 (83%), then nephrological in 7 (11%) patients, followed by various poisonings and in one case acute liver failure. Most patients had no complications related to TPE (47%). Statistical data processing did not determine predictors of long-term outcomes or treatment complications. Conclusions: The TPE procedure was most often performed in cases of neurological indications. The number of TPE procedures, complications and treatment in the PICU are not significant predictors of long-term outcomes in pediatric patients. TPE proved to be a safe procedure, that did not have a significant impact on the final outcome of the treatment. Long-term results most likely depend on the underlying disease and the patient's individual response to therapy.
Keywords
Keywords (english)
Languagecroatian
URN:NBNurn:nbn:hr:171:989668
Study programmeTitle: Medicine
Study programme type: university
Study level: integrated undergraduate and graduate
Academic / professional title: doktor/doktorica medicine (doktor/doktorica medicine)
Type of resourceText
File originBorn digital
Access conditionsOpen access
Embargo expiration date: 2024-09-23
Terms of useLicence In copyright icon
Created on2024-09-19 11:48:21