| Abstract | Cilj istraživanja:
Utvrditi najučinkovitiji način liječenja depresije u odnosu na težinu kliničke slike prema tri
ocjenske ljestvice za depresiju (Hamiltonova ocjenska ljestvica depresije, Montgomery–
Asbergova ocjenska ljestvica depresije, Opći klinički dojam), te vremenski period za
uspostavljanje psihološkog, socijalnog i radnog funkcioniranja u bolesnika oboljelih od
depresije u trajanju od 6 mjeseci.
Ustroj istraživanja:
Istraživanje je provedeno na uzorku od 40 bolesnika, a korišteni su mjerni instrumenti
(Hamiltonova ocjenska ljestvica depresije, Montgomery–Asbergova ocjenska ljestvica
depresije, Opći klinički dojam) kojima se provjeravalo stanje bolesnika nultog dana liječenja i
svaka tri tjedna tijekom liječenja u bolnici, a i nakon izlaska iz bolnice na kontrolnim
pregledima koji su bili zakazivani svaka tri tjedna.
Mjesto istraživanja:
Istraživanje je provedeno na Klinici za psihiijatriju KBC Split.
Sudionici:
U istraživanje je uključeno 40 ispitanika s kliničkom slikom depresije od kojih je 25 žena i 15
muškaraca u dobi od 28 do 60 godina hospitaliziranih na Klinici za psihijatriju KBC Split u
razdoblju od šest mjeseci.
Glavne mjere ishoda:
Kategorije depresije mjerene:
Hamiltonova ocjenska ljestvica za depresiju 17 (HAM – D17),
Montgomery – Asbergova ocjenska ljestvica za depresiju (MADRS),
Ljestvica Klinički opći dojam (CGI).
Rezultati:
Dvadesetprvi dan je uzet kao minimum liječenja jer je to upravo razdoblje u kojem bi se
trebao zamijetiti lječidbeni učinak. U ovoj studiji 12 bolesnika je otpušteno 21. dan, 20
bolesnika 42. dan, 7 bolesnika 63. dan, a samo jedan je otpušten 84. dana. Prema ljestvici
Klinički opći dojam-težina bolesti (CGI – S) nultog dana liječenja bolesnicima je određena
težina depresije: umjerenu depresiju imalo je 5 bolesnika, izrazitu 2 bolesnika, a 33 bolesnika je imalo tešku depresiju. Nakon 24. tjedna 15 bolesnika nije imalo simptoma bolesti, 18 je
imalo vrlo blagu depresiju, 6 blagu, a samo jedan bolesnik je imao umjerenu depresiju.
Zaključci:
Farmakoterapijski pristup liječenju oboljelih od depresije pokazao se kao najbolji način
liječenja oboljelih od depresije . Učinkovitost farmakoterapije pri liječenju oboljelih od
depresije se uspješno evaluira primjenom ocjenskih ljestvica za depresij. U konačnici,
farmakoterapijskim pristupom uspostavlja se dobro psihološko, socijalno i radno
funkcioniranje u ranije oboljelih od depresije u trajanju od 6 mjeseci. |
| Abstract (english) | Objectives:
To determine the most effective way of treating depression in compared to the clinical picture
by three rating scales for depression (Hamilton depression rating scale, Montgomery-
Asbergova rating scale of depression, general clinical impression), and the time period for the
establishment of psychological, social and occupational functioning in patients suffering from
depression for 6 months.
Design:
The study was conducted on a sample of 40 patients, and measuring instruments have been
used (Hamilton depression rating scale, Montgomery-Asbergova rating scale of depression,
general clinical impression) that checked zero status of the patient treatment and every three
weeks during treatment in hospital, and after discharging from the hospital to control visits
that were scheduled every three weeks.
Settings:
The research was carried out at the Department of Psychiatry at the Clinical Hospital Centre
Split.
Participants:
The study included 40 patients with clinical signs of depression, of which 25 women and 15
men aged 28-60 years hospitalized at the Clinic for Psychiatry, Clinical Hospital Centre Split
during a period of six months.
Main outcome measures:
This study used following parameters:
Hamilton rating scale for depression 17 (HAM-D17),
Montgomery-Asberg rating scale for depression (MADRS),
Clinical global impression (CGI).
Results:
Twentyfirst day is taken as a minimum treatment because it is precisely the period during
which notice should be the therapeutic effect. In this study, 12 patients were discharged 21st
day, 20 patients 42nd day, 7 patients 63rd day, and only one was released 84th days.
According to the Clinical global impression-severity (CGI-S), zero-day treatment of patients
is determined by the severity of depression: moderate depression had five patients, marked
depression had 2 patients, and 33 patients had severe depression. After 24 weeks 15 patients
had no symptoms of disease, 18 had a very mild depression, 6 mild, and only one patient had
moderate depression.
Conclusion:
Pharmacological approach to treating patients with depression proved to be the best way of
treating patients with depression. The effectiveness of pharmacotherapy in the treatment of
patients with depression are successfully evaluated using different rating scale for depression.
In the end, pharmacotherapeutic approach to well-established psychological, social and work
functioning in patients with depression before a period of 6 months. |
