| Abstract | Uvod: Sustavna skleroza (SSc) je rijetka bolest vezivnog tkiva, klinički obilježena poremećajima u vaskularnim, imunološkim i fibroznim putevima. Nutritivni status danas se koristi kao marker za aktivnost i težinu bolesti koji ujedno i predviđa smrtnost u pacijenata sa SSc.
Cilj istraživanja: Cilj ovog istraživanja bio je odrediti nutritivni status (stupanj malnutricije) bolesnika sa SSc, te odrediti moguću povezanost nutritivnog statusasa stanjem usne šupljine, sa samoprocijenjenim doživljajem zdravlja, s funkcijskom onesposobljenošću i stupnjem uznapredovalosti bolesti te s težinom kliničke slike i aktivnosti osnovne bolesti.
Metode: U istraživanju smo određivali nutritivni status (stupanj malnutricije) u 17 bolesnika sa SSc uz pomoć Malnutrition Universal Screening Tool (MUST) alata probira. Iz dobivenih podataka o nutritivnom statusu tražili smo povezanost nutritivnog statusa pacijenata sa stanjem usne šupljine mjerene OHIP-om 49, sa samoprocijenjenim doživljajem zdravlja mjerenim SF-36 upitnikom te s funkcijskom onesposobljenošću i stupnjem uznapredovalosti bolesti mjerenim SHAQ upitnikom.
Rezultati: Od ukupno 17 pacijenata, visoki rizik za razvoj malnutricije procijenjen je kod 11 pacijenata, dok je srednji rizik za razvoj malnutricije imalo 6 pacijenata. Jedine značajne razlike (P<0,05) bile su u vrijednostima SHAQ upitnika. Ispitanici s visokim rizikom malnutricije imali su značajno veće vrijednosti dobivene SHAQ upitnikom. Kod skupine s MUST visokim rizikom malnutricije uočene su značajno češće pozitivne vrijednosti SCL70, negativne ACA vrijednosti, veća aktivnost bolesti te veća učestalost općih, kožnih i zglobnih simptoma.
Zaključak: Istraživanje provedeno u ovom diplomskom radu upućuje na povezanost nutritivnog statusa (stupnja malnutricije) s težinom kliničke slike i aktivnosti osnovne bolesti. S obzirom na mali broj pacijenata uključenih u ovo istraživanje, za potpunu potvrdu zaključaka ovog ispitivanja potrebna su dodatna istraživanja na većem broju pacijenata. |
| Abstract (english) | Background: Systemic sclerosis (SSc) is a rare connective tissue disease, clinically characterized by disorders in vascular, immunological, and fibrotic pathways. Nutritional status is used as a marker for disease activity and severity, predicting mortality in patients with systemic sclerosis.
Objectives: The aim of this study was to determine the nutritional status (the degree of malnutrition) of SSc patients and to determine the possible association of nutritional status with the state of oral aperture, with self-assessed evaluation of health, functional disability and the degree of disease progression, as well as with severity and activity of the underlying disease.
Methods: In this study we determined the nutritional status (the degree of malnutrition) in 17 patients with SSc using the Malnutrition Universal Screening Tool (MUST). From the obtained data on nutritional status, we searched for the correlation of the nutritional status of patients with oral aperture state, measured by the OHIP 49, with self-assessed evaluation of health, measured bythe SF-36 questionnaire, and with the functional disability and the degree of disease progression, measured by the SHAQ questionnaire.
Results: Out of a total of 17 patients, a high risk for developing malnutrition was estimated in 11 patients, while the median risk for developing malnutrition was found in 6 patients. The only statistically significant differences (P <0.05) were obtained by the SHAQ questionnaire. The patients with high risk for developing malnutrition had significantly higher values obtained by the SHAQ questionnaire. In the MUST group with a high risk for developing malnutrition, positive SCL70 values, negative ACA values, higher disease activity and higher incidence of general, skin and joint symptoms were observed to be significantly more common.
Conclusion: The research carried out in this diploma thesis suggests that there is a correlation of nutritional status ( the degree of malnutrition) with the disease severity and the activity of the underlying disease. Given the small number of patients involved in this study, additional studies are needed on a larger number of patients to fully confirm the conclusions of this study. |
