| Abstract | Cilj: Glavni cilj istraživanja bio je ispitati postoji li razlika u vrijednostima upalnih markera (SE, CRP-a i L) te u učestalosti drugih autoimunih bolesti između oboljelih od oralnog lihen planusa (OLP) i osoba bez patoloških promjena na oralnoj sluznici.
Materijali i metode: U istraživanju je sudjelovalo ukupno 126 ispitanika, i to 63 ispitanika s dijagnozom OLP-a (ispitna skupina) i 63 ispitanika bez patoloških promjena na oralnoj sluznici (kontrolna skupina).
Anamnestički su dobiveni podatci o spolu, dobi, navikama svakodnevnog pušenja i konzumiranja alkoholnih pića te o učestalosti druge autoimune bolesti.
Svim ispitanicima izvađena je krv u svrhu određivanja vrijednosti upalnih markera (SE, CRP-a i L).
Rezultati: Rezultati ovog istraživanja pokazali su kako nije bilo značajne razlike u prosječnoj vrijednosti SE (12,17 mm/h vs. 12,36 mm/h; P = 0,902), CRP-a (3,56 mg/L vs. 2,45 mg/L; P = 0,270) ni L (5,84 x 109/L vs. 6,01 x 109/L; P = 0,575) između ispitivanih skupina.
Što se tiče učestalosti druge autoimune bolesti, ona je bila značajno veća u oboljelih od OLP-a (39,68 % vs. 6,35 %; P < 0,001). Najčešća druga autoimuna bolest u oboljelih od OLP-a bio je kožni lihen u 9 ispitanika (14,29 %), a zatim celijakija u njih 7 (11,11 %).
Među ispitivanim skupinama nije bilo značajne razlike u navikama svakodnevnog pušenja i konzumacije alkoholnih pića (P = 0,308).
Zaključak: Temeljem dobivenih rezultata može se zaključiti kako nema značajne razlike u ispitivanim vrijednostima upalnih markera, kao ni u navikama između ispitanika oboljelih od OLP-a i ispitanika bez patoloških promjena na oralnoj sluznici, za razliku od učestalosti drugih autoimunih bolesti koja je bila značajno veća u oboljelih od OLP-a. |
| Abstract (english) | Objective: The main aim of this study was to examine whether there was a difference in inflammatory markers (SE, CRP and L) serum levels and the incidence of other autoimmune diseases between patients with oral lichen planus (OLP) and those without pathological changes on the oral mucosa.
Materials and methods: A total of 126 subjects participated in this study, of which 63 were diagnosed with OLP (study group) and 63 were without pathological changes on the oral mucosa (control group). Anamnestic data included gender, age, habits of daily smoking and alcohol consumption and the frequency of other autoimmune diseases. Blood samples were obtained from each study participant to determine the values of inflammatory markers (SE, CRP, and L).
Results: The study results have shown that there was no significant difference in average value of SE (12.17 mm/h vs. 12.36 mm/h; P = 0.902), CRP (3.56 mg/L vs. 2.45 mg/L; P = 0.270) nor L (5.84 x 109/L vs. 6.01 x 109/L; P = 0.575) among tested groups. Regarding frequency of other autoimune disease, it was significally higher at patients with OLP (39.68 % vs, 6.35 %, P < 0.001). The most common other autoimune disease inpatients with OLP was cutaneous lichen (skin lichen) in 9 test respondents (14.29 %) andthe celiac disease in 7 respondents (11.11 %). Among tested groups there was no significant difference in daliy smoking habits and alcohol consumption (P = 0.308).
Conclusion: Based on provided results it can be concluded that there was no significant difference in tested values of inflammatory markers, as well as in habits, between patients with OLP and subjects without pathological changes on the oral mucosa, in contrast to the frequency of other autoimmune disease that was significantly higher in patients with OLP. |
